Evidence of peripheral axonal neuropathy in primary restless legs syndrome.
Identifieur interne : 004793 ( Ncbi/Checkpoint ); précédent : 004792; suivant : 004794Evidence of peripheral axonal neuropathy in primary restless legs syndrome.
Auteurs : S. Iannaccone [Italie] ; M. Zucconi ; P. Marchettini ; L. Ferini-Strambi ; R. Nemni ; A. Quattrini ; S. Palazzi ; M. Lacerenza ; F. Formaglio ; S. SmirneSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1995.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Axons (pathology), Electromyography, Electrophysiology, Female, Humans, Male, Middle Aged, Peripheral Nerves (pathology), Peripheral Nerves (physiopathology), Peripheral Nervous System Diseases (diagnosis), Peripheral Nervous System Diseases (pathology), Peripheral Nervous System Diseases (physiopathology), Polysomnography, Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (pathology), Restless Legs Syndrome (physiopathology), Sensory Thresholds, Thermal Conductivity.
- MESH :
- diagnosis : Peripheral Nervous System Diseases, Restless Legs Syndrome.
- pathology : Axons, Peripheral Nerves, Peripheral Nervous System Diseases, Restless Legs Syndrome.
- physiopathology : Peripheral Nerves, Peripheral Nervous System Diseases, Restless Legs Syndrome.
- Adult, Age of Onset, Aged, Electromyography, Electrophysiology, Female, Humans, Male, Middle Aged, Polysomnography, Sensory Thresholds, Thermal Conductivity.
Abstract
Restless legs syndrome (RLS) is a well-defined clinical entity characterized by an unpleasant creeping sensation arising in the legs with an irresistible need to move them. The trouble is more pronounced when the affected people lie in a prolonged rest position and try to fall asleep. It is known that RLS may be consequent to systemic disorders and to diseases affecting the central or peripheral nervous system. The International Classification of Sleep Disorders states that peripheral neuropathy should be ruled out by medical history and clinical grounds before diagnosing primary RLS (pRLS). The present study extended peripheral nerve investigation in eight consecutive pRLS patients with normal neurological examination results and showed that all patients exhibited two or more electrical, psychophysiological, and/or morphological features of peripheral axonal neuropathy. Morphometric analysis of sural nerve showed a significant reduction in myelinated fiber density and g ratio (axon diameter/fiber diameter) in the pRLS group compared with eight control biopsy specimens. These results suggest that axonal neuropathy is often present in patients with RLS. A comprehensive peripheral nerve investigation should be considered in RLS patients.
DOI: 10.1002/mds.870100103
PubMed: 7885351
Affiliations:
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Marchettini</name></author><author><name sortKey="Ferini Strambi, L" sort="Ferini Strambi, L" uniqKey="Ferini Strambi L" first="L" last="Ferini-Strambi">L. Ferini-Strambi</name></author><author><name sortKey="Nemni, R" sort="Nemni, R" uniqKey="Nemni R" first="R" last="Nemni">R. Nemni</name></author><author><name sortKey="Quattrini, A" sort="Quattrini, A" uniqKey="Quattrini A" first="A" last="Quattrini">A. Quattrini</name></author><author><name sortKey="Palazzi, S" sort="Palazzi, S" uniqKey="Palazzi S" first="S" last="Palazzi">S. Palazzi</name></author><author><name sortKey="Lacerenza, M" sort="Lacerenza, M" uniqKey="Lacerenza M" first="M" last="Lacerenza">M. Lacerenza</name></author><author><name sortKey="Formaglio, F" sort="Formaglio, F" uniqKey="Formaglio F" first="F" last="Formaglio">F. Formaglio</name></author><author><name sortKey="Smirne, S" sort="Smirne, S" uniqKey="Smirne S" first="S" last="Smirne">S. Smirne</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:7885351</idno><idno type="pmid">7885351</idno><idno type="doi">10.1002/mds.870100103</idno><idno type="wicri:Area/PubMed/Corpus">004A30</idno><idno type="wicri:Area/PubMed/Curation">004A30</idno><idno type="wicri:Area/PubMed/Checkpoint">004985</idno><idno type="wicri:Area/Ncbi/Merge">004793</idno><idno type="wicri:Area/Ncbi/Curation">004793</idno><idno type="wicri:Area/Ncbi/Checkpoint">004793</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evidence of peripheral axonal neuropathy in primary restless legs syndrome.</title><author><name sortKey="Iannaccone, S" sort="Iannaccone, S" uniqKey="Iannaccone S" first="S" last="Iannaccone">S. Iannaccone</name><affiliation wicri:level="3"><nlm:affiliation>Sleep Disorders Centre, State University, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Sleep Disorders Centre, State University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Zucconi, M" sort="Zucconi, M" uniqKey="Zucconi M" first="M" last="Zucconi">M. Zucconi</name></author><author><name sortKey="Marchettini, P" sort="Marchettini, P" uniqKey="Marchettini P" first="P" last="Marchettini">P. Marchettini</name></author><author><name sortKey="Ferini Strambi, L" sort="Ferini Strambi, L" uniqKey="Ferini Strambi L" first="L" last="Ferini-Strambi">L. Ferini-Strambi</name></author><author><name sortKey="Nemni, R" sort="Nemni, R" uniqKey="Nemni R" first="R" last="Nemni">R. Nemni</name></author><author><name sortKey="Quattrini, A" sort="Quattrini, A" uniqKey="Quattrini A" first="A" last="Quattrini">A. Quattrini</name></author><author><name sortKey="Palazzi, S" sort="Palazzi, S" uniqKey="Palazzi S" first="S" last="Palazzi">S. Palazzi</name></author><author><name sortKey="Lacerenza, M" sort="Lacerenza, M" uniqKey="Lacerenza M" first="M" last="Lacerenza">M. Lacerenza</name></author><author><name sortKey="Formaglio, F" sort="Formaglio, F" uniqKey="Formaglio F" first="F" last="Formaglio">F. Formaglio</name></author><author><name sortKey="Smirne, S" sort="Smirne, S" uniqKey="Smirne S" first="S" last="Smirne">S. Smirne</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Axons (pathology)</term><term>Electromyography</term><term>Electrophysiology</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Peripheral Nerves (pathology)</term><term>Peripheral Nerves (physiopathology)</term><term>Peripheral Nervous System Diseases (diagnosis)</term><term>Peripheral Nervous System Diseases (pathology)</term><term>Peripheral Nervous System Diseases (physiopathology)</term><term>Polysomnography</term><term>Restless Legs Syndrome (diagnosis)</term><term>Restless Legs Syndrome (pathology)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Sensory Thresholds</term><term>Thermal Conductivity</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Peripheral Nervous System Diseases</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Axons</term><term>Peripheral Nerves</term><term>Peripheral Nervous System Diseases</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Peripheral Nerves</term><term>Peripheral Nervous System Diseases</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Electromyography</term><term>Electrophysiology</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term><term>Sensory Thresholds</term><term>Thermal Conductivity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) is a well-defined clinical entity characterized by an unpleasant creeping sensation arising in the legs with an irresistible need to move them. The trouble is more pronounced when the affected people lie in a prolonged rest position and try to fall asleep. It is known that RLS may be consequent to systemic disorders and to diseases affecting the central or peripheral nervous system. The International Classification of Sleep Disorders states that peripheral neuropathy should be ruled out by medical history and clinical grounds before diagnosing primary RLS (pRLS). The present study extended peripheral nerve investigation in eight consecutive pRLS patients with normal neurological examination results and showed that all patients exhibited two or more electrical, psychophysiological, and/or morphological features of peripheral axonal neuropathy. Morphometric analysis of sural nerve showed a significant reduction in myelinated fiber density and g ratio (axon diameter/fiber diameter) in the pRLS group compared with eight control biopsy specimens. These results suggest that axonal neuropathy is often present in patients with RLS. A comprehensive peripheral nerve investigation should be considered in RLS patients.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><noCountry><name sortKey="Ferini Strambi, L" sort="Ferini Strambi, L" uniqKey="Ferini Strambi L" first="L" last="Ferini-Strambi">L. Ferini-Strambi</name><name sortKey="Formaglio, F" sort="Formaglio, F" uniqKey="Formaglio F" first="F" last="Formaglio">F. Formaglio</name><name sortKey="Lacerenza, M" sort="Lacerenza, M" uniqKey="Lacerenza M" first="M" last="Lacerenza">M. Lacerenza</name><name sortKey="Marchettini, P" sort="Marchettini, P" uniqKey="Marchettini P" first="P" last="Marchettini">P. Marchettini</name><name sortKey="Nemni, R" sort="Nemni, R" uniqKey="Nemni R" first="R" last="Nemni">R. Nemni</name><name sortKey="Palazzi, S" sort="Palazzi, S" uniqKey="Palazzi S" first="S" last="Palazzi">S. Palazzi</name><name sortKey="Quattrini, A" sort="Quattrini, A" uniqKey="Quattrini A" first="A" last="Quattrini">A. Quattrini</name><name sortKey="Smirne, S" sort="Smirne, S" uniqKey="Smirne S" first="S" last="Smirne">S. Smirne</name><name sortKey="Zucconi, M" sort="Zucconi, M" uniqKey="Zucconi M" first="M" last="Zucconi">M. Zucconi</name></noCountry><country name="Italie"><region name="Lombardie"><name sortKey="Iannaccone, S" sort="Iannaccone, S" uniqKey="Iannaccone S" first="S" last="Iannaccone">S. Iannaccone</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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