Abnormal vestibuloocular reflex cancellation in multiple system atrophy and progressive supranuclear palsy but not in Parkinson's disease.
Identifieur interne : 004748 ( Ncbi/Checkpoint ); précédent : 004747; suivant : 004749Abnormal vestibuloocular reflex cancellation in multiple system atrophy and progressive supranuclear palsy but not in Parkinson's disease.
Auteurs : O. Rascol [France] ; U. Sabatini ; N. Fabre ; J M Senard ; M. Simonetta-Moreau ; J L Montastruc ; M. Clanet ; A. RascolSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1995.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Atrophy, Cerebral Palsy, Parkinson Disease.
- pathology : Brain.
- physiopathology : Atrophy, Cerebral Palsy, Parkinson Disease.
- Age Factors, Aged, Diagnosis, Differential, Humans, Middle Aged, Reflex, Vestibulo-Ocular.
Abstract
We have measured the gain of the vestibuloocular reflex (VOR) in darkness and its cancellation by fixation in 37 patients with Parkinson's disease (PD), 26 patients with multiple system atrophy (MSA), 11 patients with progressive supranuclear palsy (PSP), and 19 normal volunteers. The capacity to cancel the VOR by fixation (VOR cancellation) was significantly reduced in the MSA and PSP patients compared with the PD and normal subjects (p < 10(-4)). A VOR cancellation < 90% (i.e., the mean VOR cancellation of the normals--2 SD) was present in four PD patients, 23 MSA patients, and 11 PSP patients. This criteria distinguished PD and MSA with a 89% sensitivity and a 89% specificity. Our results demonstrate that the VOR cancellation is impaired in most patients with MSA and PSP but not with PD. In MSA patients, the abnormal VOR cancellation is probably not related to the nigrostriatal dopaminergic deficit and more likely reflects a cerebellar dysfunction. Impaired VOR cancellation is a clinical criteria to differentiate MSA and PSP from PD.
DOI: 10.1002/mds.870100206
PubMed: 7753058
Affiliations:
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Sabatini</name></author><author><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N" last="Fabre">N. Fabre</name></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Simonetta Moreau, M" sort="Simonetta Moreau, M" uniqKey="Simonetta Moreau M" first="M" last="Simonetta-Moreau">M. Simonetta-Moreau</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Clanet, M" sort="Clanet, M" uniqKey="Clanet M" first="M" last="Clanet">M. Clanet</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:7753058</idno><idno type="pmid">7753058</idno><idno type="doi">10.1002/mds.870100206</idno><idno type="wicri:Area/PubMed/Corpus">004A14</idno><idno type="wicri:Area/PubMed/Curation">004A14</idno><idno type="wicri:Area/PubMed/Checkpoint">004A30</idno><idno type="wicri:Area/Ncbi/Merge">004748</idno><idno type="wicri:Area/Ncbi/Curation">004748</idno><idno type="wicri:Area/Ncbi/Checkpoint">004748</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Abnormal vestibuloocular reflex cancellation in multiple system atrophy and progressive supranuclear palsy but not in Parkinson's disease.</title><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Medical and Clinical Pharmacology (INSERM U 317), University Hospital of Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Medical and Clinical Pharmacology (INSERM U 317), University Hospital of Toulouse</wicri:regionArea><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author><author><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N" last="Fabre">N. Fabre</name></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Simonetta Moreau, M" sort="Simonetta Moreau, M" uniqKey="Simonetta Moreau M" first="M" last="Simonetta-Moreau">M. Simonetta-Moreau</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Clanet, M" sort="Clanet, M" uniqKey="Clanet M" first="M" last="Clanet">M. Clanet</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Atrophy (diagnosis)</term><term>Atrophy (physiopathology)</term><term>Brain (pathology)</term><term>Cerebral Palsy (diagnosis)</term><term>Cerebral Palsy (physiopathology)</term><term>Diagnosis, Differential</term><term>Humans</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Reflex, Vestibulo-Ocular</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Atrophy</term><term>Cerebral Palsy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Atrophy</term><term>Cerebral Palsy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Diagnosis, Differential</term><term>Humans</term><term>Middle Aged</term><term>Reflex, Vestibulo-Ocular</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have measured the gain of the vestibuloocular reflex (VOR) in darkness and its cancellation by fixation in 37 patients with Parkinson's disease (PD), 26 patients with multiple system atrophy (MSA), 11 patients with progressive supranuclear palsy (PSP), and 19 normal volunteers. The capacity to cancel the VOR by fixation (VOR cancellation) was significantly reduced in the MSA and PSP patients compared with the PD and normal subjects (p < 10(-4)). A VOR cancellation < 90% (i.e., the mean VOR cancellation of the normals--2 SD) was present in four PD patients, 23 MSA patients, and 11 PSP patients. This criteria distinguished PD and MSA with a 89% sensitivity and a 89% specificity. Our results demonstrate that the VOR cancellation is impaired in most patients with MSA and PSP but not with PD. In MSA patients, the abnormal VOR cancellation is probably not related to the nigrostriatal dopaminergic deficit and more likely reflects a cerebellar dysfunction. Impaired VOR cancellation is a clinical criteria to differentiate MSA and PSP from PD.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Clanet, M" sort="Clanet, M" uniqKey="Clanet M" first="M" last="Clanet">M. Clanet</name><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N" last="Fabre">N. Fabre</name><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name><name sortKey="Simonetta Moreau, M" sort="Simonetta Moreau, M" uniqKey="Simonetta Moreau M" first="M" last="Simonetta-Moreau">M. Simonetta-Moreau</name></noCountry><country name="France"><noRegion><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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