Antiparkinsonian activity of a single oral dose of PHNO.
Identifieur interne : 004563 ( Ncbi/Checkpoint ); précédent : 004562; suivant : 004564Antiparkinsonian activity of a single oral dose of PHNO.
Auteurs : F. Grandas [Royaume-Uni] ; N. Quinn ; P. Critchley ; A. Rohan ; C D Marsden ; S M StahlSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1987.
English descriptors
- KwdEn :
- Administration, Oral, Adult, Aged, Carbidopa (administration & dosage), Carbidopa (therapeutic use), Dopamine Agents (administration & dosage), Dopamine Agents (adverse effects), Dopamine Agents (therapeutic use), Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, Female, Humans, Levodopa (administration & dosage), Levodopa (therapeutic use), Male, Middle Aged, Oxazines (administration & dosage), Oxazines (adverse effects), Oxazines (therapeutic use), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (drug therapy), Parkinson Disease, Secondary (pathology), Reaction Time.
- MESH :
- chemical , administration & dosage : Carbidopa, Dopamine Agents, Levodopa, Oxazines.
- chemical , adverse effects : Dopamine Agents, Oxazines.
- chemical , therapeutic use : Carbidopa, Dopamine Agents, Levodopa, Oxazines.
- chemically induced : Parkinson Disease, Secondary.
- drug therapy : Parkinson Disease, Secondary.
- pathology : Parkinson Disease, Secondary.
- Administration, Oral, Adult, Aged, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, Female, Humans, Male, Middle Aged, Reaction Time.
Abstract
PHNO, a new D-2 agonist, was investigated in five patients with Parkinson's disease. In an acute, open, oral, dose-ranging study comparing benefit from single doses, 4 mg of PHNO was found to be equivalent to one tablet of Sinemet 25/250 mg. Adverse reactions were those anticipated for a dopaminomimetic agent. Because of its novel structure and apparent transcutaneous penetration, further studies on PHNO are desirable.
DOI: 10.1002/mds.870020106
PubMed: 2904120
Affiliations:
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pubmed:2904120Le document en format XML
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Critchley</name></author><author><name sortKey="Rohan, A" sort="Rohan, A" uniqKey="Rohan A" first="A" last="Rohan">A. Rohan</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C D" last="Marsden">C D Marsden</name></author><author><name sortKey="Stahl, S M" sort="Stahl, S M" uniqKey="Stahl S" first="S M" last="Stahl">S M Stahl</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1987">1987</date><idno type="RBID">pubmed:2904120</idno><idno type="pmid">2904120</idno><idno type="doi">10.1002/mds.870020106</idno><idno type="wicri:Area/PubMed/Corpus">005092</idno><idno type="wicri:Area/PubMed/Curation">005092</idno><idno type="wicri:Area/PubMed/Checkpoint">005088</idno><idno type="wicri:Area/Ncbi/Merge">004563</idno><idno type="wicri:Area/Ncbi/Curation">004563</idno><idno type="wicri:Area/Ncbi/Checkpoint">004563</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiparkinsonian activity of a single oral dose of PHNO.</title><author><name sortKey="Grandas, F" sort="Grandas, F" uniqKey="Grandas F" first="F" last="Grandas">F. Grandas</name><affiliation wicri:level="3"><nlm:affiliation>University Department of Neurology, King's College Hospital Medical School, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Department of Neurology, King's College Hospital Medical School, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Quinn, N" sort="Quinn, N" uniqKey="Quinn N" first="N" last="Quinn">N. Quinn</name></author><author><name sortKey="Critchley, P" sort="Critchley, P" uniqKey="Critchley P" first="P" last="Critchley">P. Critchley</name></author><author><name sortKey="Rohan, A" sort="Rohan, A" uniqKey="Rohan A" first="A" last="Rohan">A. Rohan</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C D" last="Marsden">C D Marsden</name></author><author><name sortKey="Stahl, S M" sort="Stahl, S M" uniqKey="Stahl S" first="S M" last="Stahl">S M Stahl</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Aged</term><term>Carbidopa (administration & dosage)</term><term>Carbidopa (therapeutic use)</term><term>Dopamine Agents (administration & dosage)</term><term>Dopamine Agents (adverse effects)</term><term>Dopamine Agents (therapeutic use)</term><term>Dose-Response Relationship, Drug</term><term>Drug Administration Schedule</term><term>Drug Combinations</term><term>Female</term><term>Humans</term><term>Levodopa (administration & dosage)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Oxazines (administration & dosage)</term><term>Oxazines (adverse effects)</term><term>Oxazines (therapeutic use)</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (drug therapy)</term><term>Parkinson Disease, Secondary (pathology)</term><term>Reaction Time</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Carbidopa</term><term>Dopamine Agents</term><term>Levodopa</term><term>Oxazines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dopamine Agents</term><term>Oxazines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Carbidopa</term><term>Dopamine Agents</term><term>Levodopa</term><term>Oxazines</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Aged</term><term>Dose-Response Relationship, Drug</term><term>Drug Administration Schedule</term><term>Drug Combinations</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reaction Time</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">PHNO, a new D-2 agonist, was investigated in five patients with Parkinson's disease. In an acute, open, oral, dose-ranging study comparing benefit from single doses, 4 mg of PHNO was found to be equivalent to one tablet of Sinemet 25/250 mg. Adverse reactions were those anticipated for a dopaminomimetic agent. Because of its novel structure and apparent transcutaneous penetration, further studies on PHNO are desirable.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Critchley, P" sort="Critchley, P" uniqKey="Critchley P" first="P" last="Critchley">P. Critchley</name><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C D" last="Marsden">C D Marsden</name><name sortKey="Quinn, N" sort="Quinn, N" uniqKey="Quinn N" first="N" last="Quinn">N. Quinn</name><name sortKey="Rohan, A" sort="Rohan, A" uniqKey="Rohan A" first="A" last="Rohan">A. Rohan</name><name sortKey="Stahl, S M" sort="Stahl, S M" uniqKey="Stahl S" first="S M" last="Stahl">S M Stahl</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Grandas, F" sort="Grandas, F" uniqKey="Grandas F" first="F" last="Grandas">F. Grandas</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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