Lower body parkinsonism: evidence for vascular etiology.
Identifieur interne : 004542 ( Ncbi/Checkpoint ); précédent : 004541; suivant : 004543Lower body parkinsonism: evidence for vascular etiology.
Auteurs : P M Fitzgerald [États-Unis] ; Joseph Jankovic [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1989.
English descriptors
- KwdEn :
- MESH :
- complications : Cerebrovascular Disorders.
- etiology : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Aged, Female, Gait, Humans, Male, Movement.
Abstract
We studied 10 patients with marked gait difficulty and no or only minimal upper limb involvement, defined here as lower body parkinsonism (LBP). They were compared to a control group of 100 patients with otherwise typical Parkinson's disease (PD). Both groups were of comparable age, but the mean duration of symptoms was significantly shorter in the LBP group (2.6 +/- 1.5 years versus 7.5 +/- 4.9 years). Gait disturbance was the initial symptom in 90% of LBP patients, as opposed to 7% of controls. Hypertension was present in 70% of LBP patients, and only 22% responded to levodopa. In contrast, only 21% of controls had a history of hypertension, and 96% improved with levodopa. We conclude that these 10 LBP patients constitute a homogenous group, distinct from typical PD. Besides their disproportionate gait disturbance, they are distinguished from PD patients by more rapid progression, higher incidence of hypertension, and a poor response to levodopa. Ischemic etiology for LBP is supported by abnormal neuroimaging studies.
DOI: 10.1002/mds.870040306
PubMed: 2779595
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004F66
- to stream PubMed, to step Curation: 004F66
- to stream PubMed, to step Checkpoint: 004F79
- to stream Ncbi, to step Merge: 004542
- to stream Ncbi, to step Curation: 004542
Links to Exploration step
pubmed:2779595Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lower body parkinsonism: evidence for vascular etiology.</title><author><name sortKey="Fitzgerald, P M" sort="Fitzgerald, P M" uniqKey="Fitzgerald P" first="P M" last="Fitzgerald">P M Fitzgerald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2779595</idno><idno type="pmid">2779595</idno><idno type="doi">10.1002/mds.870040306</idno><idno type="wicri:Area/PubMed/Corpus">004F66</idno><idno type="wicri:Area/PubMed/Curation">004F66</idno><idno type="wicri:Area/PubMed/Checkpoint">004F79</idno><idno type="wicri:Area/Ncbi/Merge">004542</idno><idno type="wicri:Area/Ncbi/Curation">004542</idno><idno type="wicri:Area/Ncbi/Checkpoint">004542</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lower body parkinsonism: evidence for vascular etiology.</title><author><name sortKey="Fitzgerald, P M" sort="Fitzgerald, P M" uniqKey="Fitzgerald P" first="P M" last="Fitzgerald">P M Fitzgerald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cerebrovascular Disorders (complications)</term><term>Female</term><term>Gait</term><term>Humans</term><term>Male</term><term>Movement</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cerebrovascular Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Gait</term><term>Humans</term><term>Male</term><term>Movement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied 10 patients with marked gait difficulty and no or only minimal upper limb involvement, defined here as lower body parkinsonism (LBP). They were compared to a control group of 100 patients with otherwise typical Parkinson's disease (PD). Both groups were of comparable age, but the mean duration of symptoms was significantly shorter in the LBP group (2.6 +/- 1.5 years versus 7.5 +/- 4.9 years). Gait disturbance was the initial symptom in 90% of LBP patients, as opposed to 7% of controls. Hypertension was present in 70% of LBP patients, and only 22% responded to levodopa. In contrast, only 21% of controls had a history of hypertension, and 96% improved with levodopa. We conclude that these 10 LBP patients constitute a homogenous group, distinct from typical PD. Besides their disproportionate gait disturbance, they are distinguished from PD patients by more rapid progression, higher incidence of hypertension, and a poor response to levodopa. Ischemic etiology for LBP is supported by abnormal neuroimaging studies.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Fitzgerald, P M" sort="Fitzgerald, P M" uniqKey="Fitzgerald P" first="P M" last="Fitzgerald">P M Fitzgerald</name></region><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004542 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 004542 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:2779595
|texte= Lower body parkinsonism: evidence for vascular etiology.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:2779595" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |