MovDisordV3, Ncbi, Checkpoint, bibRecord, 003698

Brain amyloid and cognition in Lewy body diseases

Identifieur interne : 003698 ( Ncbi/Checkpoint ); précédent : 003697; suivant : 003699

Brain amyloid and cognition in Lewy body diseases

Auteurs : S. N. Gomperts ; J. J. Locascio ; M. Marquie ; A. L. Santarlasci ; D. M. Rentz ; J. Maye ; K. A. Johnson ; J. H. Growdon

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.

RBID : PMC:3725259

English descriptors

KwdEn :
- Aged, Amyloid beta-Peptides (metabolism), Aniline Compounds (metabolism), Antiparkinson Agents (therapeutic use), Apolipoprotein E3 (genetics), Cognition, Female, Genotype, Humans, Levodopa (therapeutic use), Lewy Body Disease (metabolism), Lewy Body Disease (psychology), Lewy Body Disease (radionuclide imaging), Male, Mild Cognitive Impairment (metabolism), Mild Cognitive Impairment (psychology), Neurologic Examination, Neuropsychological Tests, Parkinson Disease (metabolism), Parkinson Disease (psychology), Positron-Emission Tomography, Thiazoles (metabolism).
MESH :
- chemical , genetics : Apolipoprotein E3.
- chemical , metabolism : Amyloid beta-Peptides, Aniline Compounds, Thiazoles.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- metabolism : Lewy Body Disease, Mild Cognitive Impairment, Parkinson Disease.
- psychology : Lewy Body Disease, Mild Cognitive Impairment, Parkinson Disease.
- radionuclide imaging : Lewy Body Disease.
- Aged, Cognition, Female, Genotype, Humans, Male, Neurologic Examination, Neuropsychological Tests, Positron-Emission Tomography.

Abstract

Background

Many patients with Parkinson disease (PD) develop dementia (PDD), a syndrome that overlaps clinically and pathologically with dementia with Lewy bodies (DLB); PDD and DLB differ chiefly in the relative timing of dementia and parkinsonism. Brain amyloid deposition is an early feature of DLB and may account in part for its early dementia. We sought to confirm this hypothesis and also to determine whether amyloid accumulation contributes to cognitive impairment and dementia in the broad range of parkinsonian diseases.

Methods

29 cognitively normal PD, 14 PD subjects with mild cognitive impairment (PD-MCI), 18 with DLB, 12 with PDD and 85 healthy control subjects (HCS) underwent standardized neurologic and neuropsychological examinations and PiB imaging with PET. Apolipoprotein (APOE) genotypes were obtained in many patients. PiB retention was expressed as the distribution volume ratio using a cerebellar tissue reference.

Results

PiB retention was significantly higher in DLB than in any of the other diagnostic groups. PiB retention did not differ across PDD, PD-MCI, PD, and HCS. Amyloid burden increased with age and with the presence of the APOEε4 allele in all patient groups. Only in the DLB group was amyloid deposition associated with impaired cognition.

Conclusions

DLB subjects have higher amyloid burden than subjects with PDD, PD-MCI, PD or HCS; amyloid deposits are linked to cognitive impairment only in DLB. Early amyloid deposits in DLB relative to PDD may account for their difference in the timing of dementia and parkinsonism.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725259

DOI: 10.1002/mds.25048
PubMed: 22693110
PubMed Central: 3725259

Affiliations:

Links to Exploration step

PMC:3725259

Le document en format XML

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<author><name sortKey="Locascio, J J" sort="Locascio, J J" uniqKey="Locascio J" first="J. J." last="Locascio">J. J. Locascio</name>
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<author><name sortKey="Johnson, K A" sort="Johnson, K A" uniqKey="Johnson K" first="K. A." last="Johnson">K. A. Johnson</name>
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<term>Antiparkinson Agents (therapeutic use)</term>
<term>Apolipoprotein E3 (genetics)</term>
<term>Cognition</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
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<term>Lewy Body Disease (metabolism)</term>
<term>Lewy Body Disease (psychology)</term>
<term>Lewy Body Disease (radionuclide imaging)</term>
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<term>Parkinson Disease (psychology)</term>
<term>Positron-Emission Tomography</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Many patients with Parkinson disease (PD) develop dementia (PDD), a syndrome that overlaps clinically and pathologically with dementia with Lewy bodies (DLB); PDD and DLB differ chiefly in the relative timing of dementia and parkinsonism. Brain amyloid deposition is an early feature of DLB and may account in part for its early dementia. We sought to confirm this hypothesis and also to determine whether amyloid accumulation contributes to cognitive impairment and dementia in the broad range of parkinsonian diseases.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">29 cognitively normal PD, 14 PD subjects with mild cognitive impairment (PD-MCI), 18 with DLB, 12 with PDD and 85 healthy control subjects (HCS) underwent standardized neurologic and neuropsychological examinations and PiB imaging with PET. Apolipoprotein (APOE) genotypes were obtained in many patients. PiB retention was expressed as the distribution volume ratio using a cerebellar tissue reference.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">PiB retention was significantly higher in DLB than in any of the other diagnostic groups. PiB retention did not differ across PDD, PD-MCI, PD, and HCS. Amyloid burden increased with age and with the presence of the APOEε4 allele in all patient groups. Only in the DLB group was amyloid deposition associated with impaired cognition.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">DLB subjects have higher amyloid burden than subjects with PDD, PD-MCI, PD or HCS; amyloid deposits are linked to cognitive impairment only in DLB. Early amyloid deposits in DLB relative to PDD may account for their difference in the timing of dementia and parkinsonism.</p>
</sec>
</div>
</front>
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<name sortKey="Johnson, K A" sort="Johnson, K A" uniqKey="Johnson K" first="K. A." last="Johnson">K. A. Johnson</name>
<name sortKey="Locascio, J J" sort="Locascio, J J" uniqKey="Locascio J" first="J. J." last="Locascio">J. J. Locascio</name>
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<name sortKey="Rentz, D M" sort="Rentz, D M" uniqKey="Rentz D" first="D. M." last="Rentz">D. M. Rentz</name>
<name sortKey="Santarlasci, A L" sort="Santarlasci, A L" uniqKey="Santarlasci A" first="A. L." last="Santarlasci">A. L. Santarlasci</name>
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Movement Disorders (revue)

Brain amyloid and cognition in Lewy body diseases

Brain amyloid and cognition in Lewy body diseases

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki

	Movement Disorders (revue)
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