Wine drinking and essential tremor: a possible protective role.
Identifieur interne : 003168 ( Ncbi/Checkpoint ); précédent : 003167; suivant : 003169Wine drinking and essential tremor: a possible protective role.
Auteurs : Alessandra Nicoletti [Italie] ; Giovanni Mostile ; Roberto Cappellani ; Donatella Contrafatto ; Gennarina Arabia ; Paolo Lamberti ; Roberto Marconi ; Letterio Morgante ; Paolo Barone ; Aldo Quattrone ; Mario ZappiaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Alcohol Drinking (epidemiology), Antioxidants (administration & dosage), Case-Control Studies, Coffee, Essential Tremor (epidemiology), Essential Tremor (prevention & control), Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Neuroprotective Agents (administration & dosage), Prevalence, Questionnaires, Smoking (epidemiology), Wine.
- MESH :
- chemical , administration & dosage : Antioxidants, Neuroprotective Agents.
- epidemiology : Alcohol Drinking, Essential Tremor, Smoking.
- prevention & control : Essential Tremor.
- Aged, Case-Control Studies, Coffee, Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Prevalence, Questionnaires, Wine.
Abstract
The purpose of this study was to evaluate the possible association of cigarette smoking, coffee drinking, and wine consumption with essential tremor using a matched case-control design. Cases and controls were enrolled from 6 Movement Disorder centers in central-southern Italy. Essential tremor was diagnosed according to Bain's criteria. Three unrelated healthy controls (not affected by neurological disorders) per each enrolled case, matched by sex and age (± 5 years), were selected. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. All cases and controls underwent a standard neurological examination. Adjusted odds ratios and 95% confidence intervals were estimated using conditional logistic regression for the matched cases and controls. Eighty-three patients with essential tremor (38 men and 45 women; mean age, 68.2 ± 8.6 years) and 245 matched control subjects (113 men and 132 women; mean age, 68.4 ± 9.7 years) were enrolled in the study. Multivariate analysis showed a significant negative association between essential tremor and wine consumption preceding the onset of disease (adjusted odds ratio, 0.23; 95% confidence interval, 0.08-0.64; P = .0005) with a significant dose effect (1-2 glass of wine per day: odds ratio, 0.32; 95% confidence interval, 0.10-0.95; P = .04; more than 3 glass of wine per day: odds ratio, 0.14; 95% confidence interval, 0.03-0.62; P = .01). In our sample no association between essential tremor and cigarette smoking or coffee drinking was found. Our data suggest a negative association between wine drinking and essential tremor, which could be explained by the long-term neuroprotective effect of its antioxidant components.
DOI: 10.1002/mds.23603
PubMed: 21506162
Affiliations:
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wicri:level="1"><nlm:affiliation>Dipartimento di Neuroscienze, Università di Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Università di Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Mostile, Giovanni" sort="Mostile, Giovanni" uniqKey="Mostile G" first="Giovanni" last="Mostile">Giovanni Mostile</name></author><author><name sortKey="Cappellani, Roberto" sort="Cappellani, Roberto" uniqKey="Cappellani R" first="Roberto" last="Cappellani">Roberto Cappellani</name></author><author><name sortKey="Contrafatto, Donatella" sort="Contrafatto, Donatella" uniqKey="Contrafatto D" first="Donatella" last="Contrafatto">Donatella Contrafatto</name></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name></author><author><name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></author><author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alcohol Drinking (epidemiology)</term><term>Antioxidants (administration & dosage)</term><term>Case-Control Studies</term><term>Coffee</term><term>Essential Tremor (epidemiology)</term><term>Essential Tremor (prevention & control)</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neuroprotective Agents (administration & dosage)</term><term>Prevalence</term><term>Questionnaires</term><term>Smoking (epidemiology)</term><term>Wine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antioxidants</term><term>Neuroprotective Agents</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Alcohol Drinking</term><term>Essential Tremor</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Coffee</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Prevalence</term><term>Questionnaires</term><term>Wine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to evaluate the possible association of cigarette smoking, coffee drinking, and wine consumption with essential tremor using a matched case-control design. Cases and controls were enrolled from 6 Movement Disorder centers in central-southern Italy. Essential tremor was diagnosed according to Bain's criteria. Three unrelated healthy controls (not affected by neurological disorders) per each enrolled case, matched by sex and age (± 5 years), were selected. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. All cases and controls underwent a standard neurological examination. Adjusted odds ratios and 95% confidence intervals were estimated using conditional logistic regression for the matched cases and controls. Eighty-three patients with essential tremor (38 men and 45 women; mean age, 68.2 ± 8.6 years) and 245 matched control subjects (113 men and 132 women; mean age, 68.4 ± 9.7 years) were enrolled in the study. Multivariate analysis showed a significant negative association between essential tremor and wine consumption preceding the onset of disease (adjusted odds ratio, 0.23; 95% confidence interval, 0.08-0.64; P = .0005) with a significant dose effect (1-2 glass of wine per day: odds ratio, 0.32; 95% confidence interval, 0.10-0.95; P = .04; more than 3 glass of wine per day: odds ratio, 0.14; 95% confidence interval, 0.03-0.62; P = .01). In our sample no association between essential tremor and cigarette smoking or coffee drinking was found. Our data suggest a negative association between wine drinking and essential tremor, which could be explained by the long-term neuroprotective effect of its antioxidant components.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Cappellani, Roberto" sort="Cappellani, Roberto" uniqKey="Cappellani R" first="Roberto" last="Cappellani">Roberto Cappellani</name><name sortKey="Contrafatto, Donatella" sort="Contrafatto, Donatella" uniqKey="Contrafatto D" first="Donatella" last="Contrafatto">Donatella Contrafatto</name><name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><name sortKey="Mostile, Giovanni" sort="Mostile, Giovanni" uniqKey="Mostile G" first="Giovanni" last="Mostile">Giovanni Mostile</name><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name></noCountry><country name="Italie"><noRegion><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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