A motor cortex excitability and gait analysis on Parkinsonian patients.
Identifieur interne : 002E86 ( Ncbi/Checkpoint ); précédent : 002E85; suivant : 002E87A motor cortex excitability and gait analysis on Parkinsonian patients.
Auteurs : François Vacherot [France] ; Shahram Attarian ; Marianne Vaugoyeau ; Jean-Philippe AzulaySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Electric Stimulation, Electromyography, Evoked Potentials, Motor (physiology), Female, Gait (physiology), Humans, Male, Middle Aged, Motor Cortex (physiopathology), Muscle, Skeletal (physiopathology), Parkinson Disease (physiopathology), Statistics, Nonparametric, Transcranial Magnetic Stimulation.
- MESH :
- physiology : Evoked Potentials, Motor, Gait.
- physiopathology : Motor Cortex, Muscle, Skeletal, Parkinson Disease.
- Aged, Electric Stimulation, Electromyography, Female, Humans, Male, Middle Aged, Statistics, Nonparametric, Transcranial Magnetic Stimulation.
Abstract
Transcranial magnetic stimulation (TMS) parameters were recorded in a lower limb muscle and correlated with the gait parameters of 25 patients with Parkinson's disease (PD) with and without dopamine substitution treatment (DST) and 10 control subjects. Single and paired-pulse TMS were recorded in the tibialis anterior muscle (TA). Gait analysis was performed using a 3D motion analysis system. Parkinsonian patients (PP) did not differ from the control subjects (CS) in terms of relaxed motor threshold, active motor threshold (AMT), cortical silent period (CSP), motor-evoked potential (MEP) amplitude and area, or paired-pulse TMS with short interstimulus intervals (ISI). At longer ISIs, paired-pulse TMS showed that the amplitudes of the conditioned MEPs were lower in untreated PP than in CS. DST partially compensated for this difference. Gait analysis showed that the gait of PP undergoing no treatment was slower and the stride length shorter than normal. Both of these parameters improved under DST, however. Analysis of data obtained on all the subjects combined showed that both of the latter parameters were correlated with the paired-pulse MEP amplitude and area at longer ISIs. In PP, the cortical areas responsible for the lower limb movements seem to undergo intracortical facilitation (ICF) impairments, whereas the intracortical inhibition process is normal. The ICF level was found to be associated to the stride length and the velocity. The fact that only these two gait parameters were found to be dopa responsive indicates that dopaminergic treatment may improve gait disorders by restoring the ICF.
DOI: 10.1002/mds.23378
PubMed: 20925071
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A motor cortex excitability and gait analysis on Parkinsonian patients.</title><author><name sortKey="Vacherot, Francois" sort="Vacherot, Francois" uniqKey="Vacherot F" first="François" last="Vacherot">François Vacherot</name><affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR 6149, Pôle 3C, Equipe Développement et Pathologie de l'Action, Université de Provence & CNRS, Centre Saint Charles, Marseille, France. francois.vacherot@aliceadsl.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 6149, Pôle 3C, Equipe Développement et Pathologie de l'Action, Université de Provence & CNRS, Centre Saint Charles, Marseille</wicri:regionArea><placeName><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Attarian, Shahram" sort="Attarian, Shahram" uniqKey="Attarian S" first="Shahram" last="Attarian">Shahram Attarian</name></author><author><name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23378</idno><idno type="RBID">pubmed:20925071</idno><idno type="pmid">20925071</idno><idno type="wicri:Area/PubMed/Corpus">001531</idno><idno type="wicri:Area/PubMed/Curation">001531</idno><idno type="wicri:Area/PubMed/Checkpoint">001A77</idno><idno type="wicri:Area/Ncbi/Merge">002E86</idno><idno type="wicri:Area/Ncbi/Curation">002E86</idno><idno type="wicri:Area/Ncbi/Checkpoint">002E86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A motor cortex excitability and gait analysis on Parkinsonian patients.</title><author><name sortKey="Vacherot, Francois" sort="Vacherot, Francois" uniqKey="Vacherot F" first="François" last="Vacherot">François Vacherot</name><affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR 6149, Pôle 3C, Equipe Développement et Pathologie de l'Action, Université de Provence & CNRS, Centre Saint Charles, Marseille, France. francois.vacherot@aliceadsl.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 6149, Pôle 3C, Equipe Développement et Pathologie de l'Action, Université de Provence & CNRS, Centre Saint Charles, Marseille</wicri:regionArea><placeName><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Attarian, Shahram" sort="Attarian, Shahram" uniqKey="Attarian S" first="Shahram" last="Attarian">Shahram Attarian</name></author><author><name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Electric Stimulation</term><term>Electromyography</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Gait (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Muscle, Skeletal (physiopathology)</term><term>Parkinson Disease (physiopathology)</term><term>Statistics, Nonparametric</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Gait</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Muscle, Skeletal</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Electric Stimulation</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Transcranial magnetic stimulation (TMS) parameters were recorded in a lower limb muscle and correlated with the gait parameters of 25 patients with Parkinson's disease (PD) with and without dopamine substitution treatment (DST) and 10 control subjects. Single and paired-pulse TMS were recorded in the tibialis anterior muscle (TA). Gait analysis was performed using a 3D motion analysis system. Parkinsonian patients (PP) did not differ from the control subjects (CS) in terms of relaxed motor threshold, active motor threshold (AMT), cortical silent period (CSP), motor-evoked potential (MEP) amplitude and area, or paired-pulse TMS with short interstimulus intervals (ISI). At longer ISIs, paired-pulse TMS showed that the amplitudes of the conditioned MEPs were lower in untreated PP than in CS. DST partially compensated for this difference. Gait analysis showed that the gait of PP undergoing no treatment was slower and the stride length shorter than normal. Both of these parameters improved under DST, however. Analysis of data obtained on all the subjects combined showed that both of the latter parameters were correlated with the paired-pulse MEP amplitude and area at longer ISIs. In PP, the cortical areas responsible for the lower limb movements seem to undergo intracortical facilitation (ICF) impairments, whereas the intracortical inhibition process is normal. The ICF level was found to be associated to the stride length and the velocity. The fact that only these two gait parameters were found to be dopa responsive indicates that dopaminergic treatment may improve gait disorders by restoring the ICF.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Marseille</li></settlement></list><tree><noCountry><name sortKey="Attarian, Shahram" sort="Attarian, Shahram" uniqKey="Attarian S" first="Shahram" last="Attarian">Shahram Attarian</name><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><name sortKey="Vaugoyeau, Marianne" sort="Vaugoyeau, Marianne" uniqKey="Vaugoyeau M" first="Marianne" last="Vaugoyeau">Marianne Vaugoyeau</name></noCountry><country name="France"><noRegion><name sortKey="Vacherot, Francois" sort="Vacherot, Francois" uniqKey="Vacherot F" first="François" last="Vacherot">François Vacherot</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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