MovDisordV3, Ncbi, Checkpoint, bibRecord, 002D87

Heart rate changes during freezing of gait in patients with Parkinson's disease

Identifieur interne : 002D87 ( Ncbi/Checkpoint ); précédent : 002D86; suivant : 002D88

Heart rate changes during freezing of gait in patients with Parkinson's disease

Auteurs : I. Maidan [Israël] ; M. Plotnik ; A. Mirelman [États-Unis] ; N. Giladi [Israël] ; J. M. Hausdorff [Israël, États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.

RBID : PMC:2964413

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Analysis of Variance, Blood Pressure (physiology), Electrocardiography (methods), Female, Freezing Reaction, Cataleptic (physiology), Gait Disorders, Neurologic (etiology), Heart Rate (physiology), Humans, Male, Middle Aged, Parkinson Disease (complications), Walking (physiology).
MESH :
- complications : Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- methods : Electrocardiography.
- physiology : Blood Pressure, Freezing Reaction, Cataleptic, Heart Rate, Walking.
- Aged, Aged, 80 and over, Analysis of Variance, Female, Humans, Male, Middle Aged.

Abstract

Freezing of gait (FOG) is one of the most disabling symptoms that affect patients with Parkinson's disease (PD). While the patho-physiology underlying FOG largely remains an enigma, several lines of evidence suggest that the autonomic nervous system might be involved. To this end, we tested the hypothesis that heart rate (HR) increases during FOG and, further, that HR increases just prior to FOG. To evaluate these hypotheses, fifteen healthy older adults, ten patients with PD who experienced FOG and ten patients who did not were studied. Patients with PD were tested during their “off” medication state. HR and HR variability were measured as subjects carried out tasks that frequently provoke FOG. 120 FOG episodes were evaluated. During FOG, HR increased (p=0.001), by an average of 1.8 bpm, as compared to HR measured before the beginning of FOG. HR also increased just prior to FOG, by 1 bpm (p<0.0001). In contrast, during sudden stops and 180° turns, HR decreased by almost 2 bpm (p<0.0001). HR variability was not associated with FOG. To our knowledge, these findings are the first to document the association of FOG to autonomic system activation, as manifested by HR dynamics. One explanation is that the changes in HR before and during FOG may be a sympathetic response, secondary to limbic activation, that contributes to the development of freezing. While further studies are needed to evaluate these associations, the present results provide experimental evidence linking impaired motor blockades to autonomic nervous system function among patients with PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964413

DOI: 10.1002/mds.23280
PubMed: 20721914
PubMed Central: 2964413

Affiliations:

Links to Exploration step

PMC:2964413

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Heart rate changes during freezing of gait in patients with Parkinson's disease</title>
<author><name sortKey="Maidan, I" sort="Maidan, I" uniqKey="Maidan I" first="I." last="Maidan">I. Maidan</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2"> Dept of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Dept of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University</wicri:regionArea>
<wicri:noRegion>Tel-Aviv University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Plotnik, M" sort="Plotnik, M" uniqKey="Plotnik M" first="M." last="Plotnik">M. Plotnik</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mirelman, A" sort="Mirelman, A" uniqKey="Mirelman A" first="A." last="Mirelman">A. Mirelman</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Giladi, N" sort="Giladi, N" uniqKey="Giladi N" first="N." last="Giladi">N. Giladi</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Dept of Neurology, Sackler Faculty of Medicine, Tel-Aviv University, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Dept of Neurology, Sackler Faculty of Medicine, Tel-Aviv University</wicri:regionArea>
<wicri:noRegion>Tel-Aviv University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hausdorff, J M" sort="Hausdorff, J M" uniqKey="Hausdorff J" first="J. M." last="Hausdorff">J. M. Hausdorff</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2"> Dept of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Dept of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University</wicri:regionArea>
<wicri:noRegion>Tel-Aviv University</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20721914</idno>
<idno type="pmc">2964413</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964413</idno>
<idno type="RBID">PMC:2964413</idno>
<idno type="doi">10.1002/mds.23280</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000109</idno>
<idno type="wicri:Area/Pmc/Curation">000109</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000340</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001630</idno>
<idno type="wicri:Area/PubMed/Curation">001630</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001853</idno>
<idno type="wicri:Area/Ncbi/Merge">002D87</idno>
<idno type="wicri:Area/Ncbi/Curation">002D87</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002D87</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Heart rate changes during freezing of gait in patients with Parkinson's disease</title>
<author><name sortKey="Maidan, I" sort="Maidan, I" uniqKey="Maidan I" first="I." last="Maidan">I. Maidan</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2"> Dept of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Dept of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University</wicri:regionArea>
<wicri:noRegion>Tel-Aviv University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Plotnik, M" sort="Plotnik, M" uniqKey="Plotnik M" first="M." last="Plotnik">M. Plotnik</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mirelman, A" sort="Mirelman, A" uniqKey="Mirelman A" first="A." last="Mirelman">A. Mirelman</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Giladi, N" sort="Giladi, N" uniqKey="Giladi N" first="N." last="Giladi">N. Giladi</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Dept of Neurology, Sackler Faculty of Medicine, Tel-Aviv University, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Dept of Neurology, Sackler Faculty of Medicine, Tel-Aviv University</wicri:regionArea>
<wicri:noRegion>Tel-Aviv University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hausdorff, J M" sort="Hausdorff, J M" uniqKey="Hausdorff J" first="J. M." last="Hausdorff">J. M. Hausdorff</name>
<affiliation><nlm:aff id="A1">Movement Disorders Unit, Dept of Neurology, Tel-Aviv Sourasky Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Tel-Aviv Sourasky Medical Center</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2"> Dept of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea> Dept of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University</wicri:regionArea>
<wicri:noRegion>Tel-Aviv University</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Blood Pressure (physiology)</term>
<term>Electrocardiography (methods)</term>
<term>Female</term>
<term>Freezing Reaction, Cataleptic (physiology)</term>
<term>Gait Disorders, Neurologic (etiology)</term>
<term>Heart Rate (physiology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Walking (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electrocardiography</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term>
<term>Freezing Reaction, Cataleptic</term>
<term>Heart Rate</term>
<term>Walking</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P5">Freezing of gait (FOG) is one of the most disabling symptoms that affect patients with Parkinson's disease (PD). While the patho-physiology underlying FOG largely remains an enigma, several lines of evidence suggest that the autonomic nervous system might be involved. To this end, we tested the hypothesis that heart rate (HR) increases during FOG and, further, that HR increases just prior to FOG. To evaluate these hypotheses, fifteen healthy older adults, ten patients with PD who experienced FOG and ten patients who did not were studied. Patients with PD were tested during their “off” medication state. HR and HR variability were measured as subjects carried out tasks that frequently provoke FOG. 120 FOG episodes were evaluated. During FOG, HR increased (p=0.001), by an average of 1.8 bpm, as compared to HR measured before the beginning of FOG. HR also increased just prior to FOG, by 1 bpm (p<0.0001). In contrast, during sudden stops and 180° turns, HR decreased by almost 2 bpm (p<0.0001). HR variability was not associated with FOG. To our knowledge, these findings are the first to document the association of FOG to autonomic system activation, as manifested by HR dynamics. One explanation is that the changes in HR before and during FOG may be a sympathetic response, secondary to limbic activation, that contributes to the development of freezing. While further studies are needed to evaluate these associations, the present results provide experimental evidence linking impaired motor blockades to autonomic nervous system function among patients with PD.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Israël</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
</region>
</list>
<tree><noCountry><name sortKey="Plotnik, M" sort="Plotnik, M" uniqKey="Plotnik M" first="M." last="Plotnik">M. Plotnik</name>
</noCountry>
<country name="Israël"><noRegion><name sortKey="Maidan, I" sort="Maidan, I" uniqKey="Maidan I" first="I." last="Maidan">I. Maidan</name>
</noRegion>
<name sortKey="Giladi, N" sort="Giladi, N" uniqKey="Giladi N" first="N." last="Giladi">N. Giladi</name>
<name sortKey="Hausdorff, J M" sort="Hausdorff, J M" uniqKey="Hausdorff J" first="J. M." last="Hausdorff">J. M. Hausdorff</name>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Mirelman, A" sort="Mirelman, A" uniqKey="Mirelman A" first="A." last="Mirelman">A. Mirelman</name>
</region>
<name sortKey="Hausdorff, J M" sort="Hausdorff, J M" uniqKey="Hausdorff J" first="J. M." last="Hausdorff">J. M. Hausdorff</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D87 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 002D87 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Ncbi
   |étape=   Checkpoint
   |type=    RBID
   |clé=     PMC:2964413
   |texte=   Heart rate changes during freezing of gait in patients with Parkinson's disease
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i   -Sk "pubmed:20721914" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Heart rate changes during freezing of gait in patients with Parkinson's disease

Heart rate changes during freezing of gait in patients with Parkinson's disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.