Neuroanatomical correlates of apathy in Parkinson's disease: A magnetic resonance imaging study using voxel-based morphometry.
Identifieur interne : 002D21 ( Ncbi/Checkpoint ); précédent : 002D20; suivant : 002D22Neuroanatomical correlates of apathy in Parkinson's disease: A magnetic resonance imaging study using voxel-based morphometry.
Auteurs : Jennifer S A M. Reijnders [Pays-Bas] ; Bart Scholtissen ; Wim E J. Weber ; Pauline Aalten ; Frans R J. Verhey ; Albert F G. LeentjensSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- pathology : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Apathy, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests.
Abstract
Apathy is generally defined as a disorder of motivation and is considered one of the most common neuropsychiatric disturbances in Parkinson's disease (PD). Only few studies addressed the neuroanatomical correlates of apathy in PD. The aim of this article was to determine the structural correlates of apathy in PD patients. Fifty-five PD patients underwent a neuropsychiatric and neuropsychological examination, and a 3 T magnetic resonance imaging scan was acquired. A voxel-based multiple regression analysis was used to calculate correlation between gray matter density and severity measures of apathy. Apathy correlates with decreased cognitive functioning and more depressive symptoms but not with more severe motor symptoms. High apathy scores were correlated with low gray matter density values in a number of cortical brain areas: the bilateral precentral gyrus (BA 4, 6), the bilateral inferior parietal gyrus (BA 40), the bilateral inferior frontal gyrus (BA 44, 47), the bilateral insula (BA 13), the right (posterior) cingulate gyrus (BA 24, 30, 31), and the right precuneus (BA 31). Apathy in PD correlates with reduced gray matter density in a number of brain regions. The involvement of the cingulate gyrus and inferior frontal gyrus is in line with the results of earlier studies addressing apathy in patients with Alzheimer's disease or depressive disorder. Further studies addressing the pathogenesis of apathy are needed.
DOI: 10.1002/mds.23268
PubMed: 20669264
Affiliations:
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Reijnders</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University Medical Centre, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Scholtissen, Bart" sort="Scholtissen, Bart" uniqKey="Scholtissen B" first="Bart" last="Scholtissen">Bart Scholtissen</name></author><author><name sortKey="Weber, Wim E J" sort="Weber, Wim E J" uniqKey="Weber W" first="Wim E J" last="Weber">Wim E J. Weber</name></author><author><name sortKey="Aalten, Pauline" sort="Aalten, Pauline" uniqKey="Aalten P" first="Pauline" last="Aalten">Pauline Aalten</name></author><author><name sortKey="Verhey, Frans R J" sort="Verhey, Frans R J" uniqKey="Verhey F" first="Frans R J" last="Verhey">Frans R J. 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Reijnders</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University Medical Centre, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Scholtissen, Bart" sort="Scholtissen, Bart" uniqKey="Scholtissen B" first="Bart" last="Scholtissen">Bart Scholtissen</name></author><author><name sortKey="Weber, Wim E J" sort="Weber, Wim E J" uniqKey="Weber W" first="Wim E J" last="Weber">Wim E J. Weber</name></author><author><name sortKey="Aalten, Pauline" sort="Aalten, Pauline" uniqKey="Aalten P" first="Pauline" last="Aalten">Pauline Aalten</name></author><author><name sortKey="Verhey, Frans R J" sort="Verhey, Frans R J" uniqKey="Verhey F" first="Frans R J" last="Verhey">Frans R J. Verhey</name></author><author><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F G" last="Leentjens">Albert F G. Leentjens</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Apathy</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Apathy</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apathy is generally defined as a disorder of motivation and is considered one of the most common neuropsychiatric disturbances in Parkinson's disease (PD). Only few studies addressed the neuroanatomical correlates of apathy in PD. The aim of this article was to determine the structural correlates of apathy in PD patients. Fifty-five PD patients underwent a neuropsychiatric and neuropsychological examination, and a 3 T magnetic resonance imaging scan was acquired. A voxel-based multiple regression analysis was used to calculate correlation between gray matter density and severity measures of apathy. Apathy correlates with decreased cognitive functioning and more depressive symptoms but not with more severe motor symptoms. High apathy scores were correlated with low gray matter density values in a number of cortical brain areas: the bilateral precentral gyrus (BA 4, 6), the bilateral inferior parietal gyrus (BA 40), the bilateral inferior frontal gyrus (BA 44, 47), the bilateral insula (BA 13), the right (posterior) cingulate gyrus (BA 24, 30, 31), and the right precuneus (BA 31). Apathy in PD correlates with reduced gray matter density in a number of brain regions. The involvement of the cingulate gyrus and inferior frontal gyrus is in line with the results of earlier studies addressing apathy in patients with Alzheimer's disease or depressive disorder. Further studies addressing the pathogenesis of apathy are needed.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Aalten, Pauline" sort="Aalten, Pauline" uniqKey="Aalten P" first="Pauline" last="Aalten">Pauline Aalten</name><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F G" last="Leentjens">Albert F G. Leentjens</name><name sortKey="Scholtissen, Bart" sort="Scholtissen, Bart" uniqKey="Scholtissen B" first="Bart" last="Scholtissen">Bart Scholtissen</name><name sortKey="Verhey, Frans R J" sort="Verhey, Frans R J" uniqKey="Verhey F" first="Frans R J" last="Verhey">Frans R J. Verhey</name><name sortKey="Weber, Wim E J" sort="Weber, Wim E J" uniqKey="Weber W" first="Wim E J" last="Weber">Wim E J. Weber</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Reijnders, Jennifer S A M" sort="Reijnders, Jennifer S A M" uniqKey="Reijnders J" first="Jennifer S A M" last="Reijnders">Jennifer S A M. Reijnders</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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