Pallidal and thalamic deep brain stimulation in myoclonus-dystonia.
Identifieur interne : 002C44 ( Ncbi/Checkpoint ); précédent : 002C43; suivant : 002C45Pallidal and thalamic deep brain stimulation in myoclonus-dystonia.
Auteurs : Doreen Gruber [Allemagne] ; Andrea A. Kühn ; Thomas Schoenecker ; Anatol Kivi ; Thomas Trottenberg ; Karl-Titus Hoffmann ; Alireza Gharabaghi ; Ute A. Kopp ; Gerd-Helge Schneider ; Christine Klein ; Friedrich Asmus ; Andreas KupschSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Cognition Disorders (etiology), Deep Brain Stimulation (methods), Dystonic Disorders (physiopathology), Dystonic Disorders (psychology), Dystonic Disorders (therapy), Female, Globus Pallidus (physiology), Humans, Magnetic Resonance Imaging (methods), Male, Middle Aged, Mood Disorders (etiology), Quality of Life (psychology), Retrospective Studies, Thalamus (physiology).
- MESH :
- etiology : Cognition Disorders, Mood Disorders.
- methods : Deep Brain Stimulation, Magnetic Resonance Imaging.
- physiology : Globus Pallidus, Thalamus.
- physiopathology : Dystonic Disorders.
- psychology : Dystonic Disorders, Quality of Life.
- therapy : Dystonic Disorders.
- Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies.
Abstract
Deep brain stimulation (DBS) of the internal globus pallidus (GPi) and ventral intermediate thalamic nucleus (VIM) are established treatment options in primary dystonia and tremor syndromes and have been reported anecdotally to be efficacious in myoclonus-dystonia (MD). We investigated short- and long-term effects on motor function, cognition, affective state, and quality of life (QoL) of GPi- and VIM-DBS in MD. Ten MD-patients (nine epsilon-sarcoglycan-mutation-positive) were evaluated pre- and post-surgically following continuous bilateral GPi- and VIM-DBS at four time points: presurgical, 6, 12, and as a last follow-up at a mean of 62.3 months postsurgically, and in OFF-, GPi-, VIM-, and GPi-VIM-DBS conditions by validated motor [unified myoclonus rating scale (UMRS), TSUI Score, Burke-Fahn-Marsden dystonia rating scale (BFMDRS)], cognitive, affective, and QoL-scores. MD-symptoms significantly improved at 6 months post-surgery (UMRS: 61.5%, TSUI Score: 36.5%, BFMDRS: 47.3%). Beneficial effects were sustained at long-term evaluation post-surgery (UMRS: 65.5%, TSUI Score: 35.1%, BFMDRS: 48.2%). QoL was significantly ameliorated; affective status and cognition remained unchanged postsurgically irrespective of the stimulation conditions. No serious long-lasting stimulation-related adverse events (AEs) were observed. Both GPi- and VIM-DBS offer equally effective and safe treatment options for MD. With respect to fewer adverse, stimulation-induced events of GPi-DBS in comparison with VIM-DBS, GPi-DBS seems to be preferable. Combined GPi-VIM-DBS can be useful in cases of incapaciting myoclonus, refractory to GPi-DBS alone.
DOI: 10.1002/mds.23312
PubMed: 20623686
Affiliations:
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Kühn</name></author><author><name sortKey="Schoenecker, Thomas" sort="Schoenecker, Thomas" uniqKey="Schoenecker T" first="Thomas" last="Schoenecker">Thomas Schoenecker</name></author><author><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name></author><author><name sortKey="Trottenberg, Thomas" sort="Trottenberg, Thomas" uniqKey="Trottenberg T" first="Thomas" last="Trottenberg">Thomas Trottenberg</name></author><author><name sortKey="Hoffmann, Karl Titus" sort="Hoffmann, Karl Titus" uniqKey="Hoffmann K" first="Karl-Titus" last="Hoffmann">Karl-Titus Hoffmann</name></author><author><name sortKey="Gharabaghi, Alireza" sort="Gharabaghi, Alireza" uniqKey="Gharabaghi A" first="Alireza" last="Gharabaghi">Alireza Gharabaghi</name></author><author><name sortKey="Kopp, Ute A" sort="Kopp, Ute A" uniqKey="Kopp U" first="Ute A" last="Kopp">Ute A. Kopp</name></author><author><name sortKey="Schneider, Gerd Helge" sort="Schneider, Gerd Helge" uniqKey="Schneider G" first="Gerd-Helge" last="Schneider">Gerd-Helge Schneider</name></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author><author><name sortKey="Asmus, Friedrich" sort="Asmus, Friedrich" uniqKey="Asmus F" first="Friedrich" last="Asmus">Friedrich Asmus</name></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23312</idno><idno type="RBID">pubmed:20623686</idno><idno type="pmid">20623686</idno><idno type="wicri:Area/PubMed/Corpus">001773</idno><idno type="wicri:Area/PubMed/Curation">001773</idno><idno type="wicri:Area/PubMed/Checkpoint">001725</idno><idno type="wicri:Area/Ncbi/Merge">002C44</idno><idno type="wicri:Area/Ncbi/Curation">002C44</idno><idno type="wicri:Area/Ncbi/Checkpoint">002C44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pallidal and thalamic deep brain stimulation in myoclonus-dystonia.</title><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Neurology, University Medicine Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Departments of Neurology, University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kuhn, Andrea A" sort="Kuhn, Andrea A" uniqKey="Kuhn A" first="Andrea A" last="Kühn">Andrea A. Kühn</name></author><author><name sortKey="Schoenecker, Thomas" sort="Schoenecker, Thomas" uniqKey="Schoenecker T" first="Thomas" last="Schoenecker">Thomas Schoenecker</name></author><author><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name></author><author><name sortKey="Trottenberg, Thomas" sort="Trottenberg, Thomas" uniqKey="Trottenberg T" first="Thomas" last="Trottenberg">Thomas Trottenberg</name></author><author><name sortKey="Hoffmann, Karl Titus" sort="Hoffmann, Karl Titus" uniqKey="Hoffmann K" first="Karl-Titus" last="Hoffmann">Karl-Titus Hoffmann</name></author><author><name sortKey="Gharabaghi, Alireza" sort="Gharabaghi, Alireza" uniqKey="Gharabaghi A" first="Alireza" last="Gharabaghi">Alireza Gharabaghi</name></author><author><name sortKey="Kopp, Ute A" sort="Kopp, Ute A" uniqKey="Kopp U" first="Ute A" last="Kopp">Ute A. Kopp</name></author><author><name sortKey="Schneider, Gerd Helge" sort="Schneider, Gerd Helge" uniqKey="Schneider G" first="Gerd-Helge" last="Schneider">Gerd-Helge Schneider</name></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author><author><name sortKey="Asmus, Friedrich" sort="Asmus, Friedrich" uniqKey="Asmus F" first="Friedrich" last="Asmus">Friedrich Asmus</name></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cognition Disorders (etiology)</term><term>Deep Brain Stimulation (methods)</term><term>Dystonic Disorders (physiopathology)</term><term>Dystonic Disorders (psychology)</term><term>Dystonic Disorders (therapy)</term><term>Female</term><term>Globus Pallidus (physiology)</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Mood Disorders (etiology)</term><term>Quality of Life (psychology)</term><term>Retrospective Studies</term><term>Thalamus (physiology)</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Globus Pallidus</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Dystonic Disorders</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the internal globus pallidus (GPi) and ventral intermediate thalamic nucleus (VIM) are established treatment options in primary dystonia and tremor syndromes and have been reported anecdotally to be efficacious in myoclonus-dystonia (MD). We investigated short- and long-term effects on motor function, cognition, affective state, and quality of life (QoL) of GPi- and VIM-DBS in MD. Ten MD-patients (nine epsilon-sarcoglycan-mutation-positive) were evaluated pre- and post-surgically following continuous bilateral GPi- and VIM-DBS at four time points: presurgical, 6, 12, and as a last follow-up at a mean of 62.3 months postsurgically, and in OFF-, GPi-, VIM-, and GPi-VIM-DBS conditions by validated motor [unified myoclonus rating scale (UMRS), TSUI Score, Burke-Fahn-Marsden dystonia rating scale (BFMDRS)], cognitive, affective, and QoL-scores. MD-symptoms significantly improved at 6 months post-surgery (UMRS: 61.5%, TSUI Score: 36.5%, BFMDRS: 47.3%). Beneficial effects were sustained at long-term evaluation post-surgery (UMRS: 65.5%, TSUI Score: 35.1%, BFMDRS: 48.2%). QoL was significantly ameliorated; affective status and cognition remained unchanged postsurgically irrespective of the stimulation conditions. No serious long-lasting stimulation-related adverse events (AEs) were observed. Both GPi- and VIM-DBS offer equally effective and safe treatment options for MD. With respect to fewer adverse, stimulation-induced events of GPi-DBS in comparison with VIM-DBS, GPi-DBS seems to be preferable. Combined GPi-VIM-DBS can be useful in cases of incapaciting myoclonus, refractory to GPi-DBS alone.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><noCountry><name sortKey="Asmus, Friedrich" sort="Asmus, Friedrich" uniqKey="Asmus F" first="Friedrich" last="Asmus">Friedrich Asmus</name><name sortKey="Gharabaghi, Alireza" sort="Gharabaghi, Alireza" uniqKey="Gharabaghi A" first="Alireza" last="Gharabaghi">Alireza Gharabaghi</name><name sortKey="Hoffmann, Karl Titus" sort="Hoffmann, Karl Titus" uniqKey="Hoffmann K" first="Karl-Titus" last="Hoffmann">Karl-Titus Hoffmann</name><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><name sortKey="Kopp, Ute A" sort="Kopp, Ute A" uniqKey="Kopp U" first="Ute A" last="Kopp">Ute A. Kopp</name><name sortKey="Kuhn, Andrea A" sort="Kuhn, Andrea A" uniqKey="Kuhn A" first="Andrea A" last="Kühn">Andrea A. Kühn</name><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><name sortKey="Schneider, Gerd Helge" sort="Schneider, Gerd Helge" uniqKey="Schneider G" first="Gerd-Helge" last="Schneider">Gerd-Helge Schneider</name><name sortKey="Schoenecker, Thomas" sort="Schoenecker, Thomas" uniqKey="Schoenecker T" first="Thomas" last="Schoenecker">Thomas Schoenecker</name><name sortKey="Trottenberg, Thomas" sort="Trottenberg, Thomas" uniqKey="Trottenberg T" first="Thomas" last="Trottenberg">Thomas Trottenberg</name></noCountry><country name="Allemagne"><region name="Berlin"><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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