Real-time visualization of altered gastric motility by magnetic resonance imaging in patients with Parkinson's disease.
Identifieur interne : 002A98 ( Ncbi/Checkpoint ); précédent : 002A97; suivant : 002A99Real-time visualization of altered gastric motility by magnetic resonance imaging in patients with Parkinson's disease.
Auteurs : Marcus M. Unger [Allemagne] ; Katja Hattemer ; Jens C. Möller ; Katrin Schmittinger ; Katharina Mankel ; Karla Eggert ; Konstantin Strauch ; Johannes J. Tebbe ; Boris Keil ; Wolfgang H. Oertel ; Johannes T. Heverhagen ; Susanne KnakeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- methods : Magnetic Resonance Imaging.
- physiology : Gastric Emptying, Gastrointestinal Motility.
- physiopathology : Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
Gastrointestinal motility is frequently affected in Parkinson's disease (PD) and has even been reported in early stages of PD. We hypothesized that gastric motility can be assessed in vivo by real-time magnetic resonance imaging (MRI), an established, noninvasive method. After an overnight fast and a standardized test meal, 10 patients with PD (six drug naïve, four treated) and 10 healthy volunteers underwent real-time MRI scanning of the stomach. Gastric motility was quantified by calculating the gastric motility indices (GMI) from transversal oblique und sagittal oblique MRI scans. There was a trend toward a decreased gastric motility in patients with PD compared with healthy controls (Mann-Whitney test, P 0.059). This difference in peristalsis was due to a significant reduction in the amplitude of peristaltic contractions (P 0.029) and not to a decelerated velocity of the peristaltic waves (P 0.97). Real-time MRI allows direct visualization of gastric motility in PD. In this pilot study, a relatively high interindividual variability impaired accurate separation of our PD sample from healthy controls. The trend toward decreased gastric motility is in accordance with previous studies that investigated gastric motility in patients with PD using other methods. Our study provides first demonstration of a possible underlying mechanism for disturbed gastric motility in PD (reduced amplitude of contractions versus altered velocity of peristaltic waves). Further studies in drug-naïve PD patients are required to determine the discriminatory power and validity of this technique in PD.
DOI: 10.1002/mds.22841
PubMed: 20213819
Affiliations:
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Unger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps-University Marburg, Marburg, Germany. marcus.unger@med.uni-marburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps-University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Hattemer, Katja" sort="Hattemer, Katja" uniqKey="Hattemer K" first="Katja" last="Hattemer">Katja Hattemer</name></author><author><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C" last="Möller">Jens C. 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Unger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps-University Marburg, Marburg, Germany. marcus.unger@med.uni-marburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps-University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Hattemer, Katja" sort="Hattemer, Katja" uniqKey="Hattemer K" first="Katja" last="Hattemer">Katja Hattemer</name></author><author><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C" last="Möller">Jens C. Möller</name></author><author><name sortKey="Schmittinger, Katrin" sort="Schmittinger, Katrin" uniqKey="Schmittinger K" first="Katrin" last="Schmittinger">Katrin Schmittinger</name></author><author><name sortKey="Mankel, Katharina" sort="Mankel, Katharina" uniqKey="Mankel K" first="Katharina" last="Mankel">Katharina Mankel</name></author><author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name></author><author><name sortKey="Strauch, Konstantin" sort="Strauch, Konstantin" uniqKey="Strauch K" first="Konstantin" last="Strauch">Konstantin Strauch</name></author><author><name sortKey="Tebbe, Johannes J" sort="Tebbe, Johannes J" uniqKey="Tebbe J" first="Johannes J" last="Tebbe">Johannes J. Tebbe</name></author><author><name sortKey="Keil, Boris" sort="Keil, Boris" uniqKey="Keil B" first="Boris" last="Keil">Boris Keil</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name></author><author><name sortKey="Heverhagen, Johannes T" sort="Heverhagen, Johannes T" uniqKey="Heverhagen J" first="Johannes T" last="Heverhagen">Johannes T. Heverhagen</name></author><author><name sortKey="Knake, Susanne" sort="Knake, Susanne" uniqKey="Knake S" first="Susanne" last="Knake">Susanne Knake</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Gastric Emptying (physiology)</term><term>Gastrointestinal Motility (physiology)</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gastric Emptying</term><term>Gastrointestinal Motility</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gastrointestinal motility is frequently affected in Parkinson's disease (PD) and has even been reported in early stages of PD. We hypothesized that gastric motility can be assessed in vivo by real-time magnetic resonance imaging (MRI), an established, noninvasive method. After an overnight fast and a standardized test meal, 10 patients with PD (six drug naïve, four treated) and 10 healthy volunteers underwent real-time MRI scanning of the stomach. Gastric motility was quantified by calculating the gastric motility indices (GMI) from transversal oblique und sagittal oblique MRI scans. There was a trend toward a decreased gastric motility in patients with PD compared with healthy controls (Mann-Whitney test, P 0.059). This difference in peristalsis was due to a significant reduction in the amplitude of peristaltic contractions (P 0.029) and not to a decelerated velocity of the peristaltic waves (P 0.97). Real-time MRI allows direct visualization of gastric motility in PD. In this pilot study, a relatively high interindividual variability impaired accurate separation of our PD sample from healthy controls. The trend toward decreased gastric motility is in accordance with previous studies that investigated gastric motility in patients with PD using other methods. Our study provides first demonstration of a possible underlying mechanism for disturbed gastric motility in PD (reduced amplitude of contractions versus altered velocity of peristaltic waves). Further studies in drug-naïve PD patients are required to determine the discriminatory power and validity of this technique in PD.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><noCountry><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name><name sortKey="Hattemer, Katja" sort="Hattemer, Katja" uniqKey="Hattemer K" first="Katja" last="Hattemer">Katja Hattemer</name><name sortKey="Heverhagen, Johannes T" sort="Heverhagen, Johannes T" uniqKey="Heverhagen J" first="Johannes T" last="Heverhagen">Johannes T. Heverhagen</name><name sortKey="Keil, Boris" sort="Keil, Boris" uniqKey="Keil B" first="Boris" last="Keil">Boris Keil</name><name sortKey="Knake, Susanne" sort="Knake, Susanne" uniqKey="Knake S" first="Susanne" last="Knake">Susanne Knake</name><name sortKey="Mankel, Katharina" sort="Mankel, Katharina" uniqKey="Mankel K" first="Katharina" last="Mankel">Katharina Mankel</name><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C" last="Möller">Jens C. Möller</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name><name sortKey="Schmittinger, Katrin" sort="Schmittinger, Katrin" uniqKey="Schmittinger K" first="Katrin" last="Schmittinger">Katrin Schmittinger</name><name sortKey="Strauch, Konstantin" sort="Strauch, Konstantin" uniqKey="Strauch K" first="Konstantin" last="Strauch">Konstantin Strauch</name><name sortKey="Tebbe, Johannes J" sort="Tebbe, Johannes J" uniqKey="Tebbe J" first="Johannes J" last="Tebbe">Johannes J. Tebbe</name></noCountry><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Unger, Marcus M" sort="Unger, Marcus M" uniqKey="Unger M" first="Marcus M" last="Unger">Marcus M. Unger</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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