The behavior of alpha-synuclein in neurons.
Identifieur interne : 002A63 ( Ncbi/Checkpoint ); précédent : 002A62; suivant : 002A64The behavior of alpha-synuclein in neurons.
Auteurs : Doris L. Fortin [États-Unis] ; Venu M. Nemani ; Ken Nakamura ; Robert H. EdwardsSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : alpha-Synuclein.
- chemical , metabolism : Calcium, alpha-Synuclein.
- genetics : Mutation, Parkinson Disease.
- metabolism : Neurons.
- pathology : Parkinson Disease.
- Humans.
Abstract
Despite considerable evidence linking alpha-synuclein with membranes in vitro, it has proven difficult to demonstrate membrane association of the protein in vivo. alpha-Synuclein localizes to the nerve terminal, but biochemical experiments have not revealed a tight association with membranes. To address the dynamics of the protein in live cells, we have used photobleaching and found that alpha-synuclein exhibits high mobility, although distinctly less than an entirely soluble protein. Further, neural activity controls the distribution of alpha-synuclein, causing its dispersion from the synapse. In addition to the presumed role of alpha-synuclein dynamics in synaptic function, changes in its physiological behavior may underlie the pathological changes associated with Parkinson's disease.
DOI: 10.1002/mds.22722
PubMed: 20187244
Affiliations:
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pubmed:20187244Le document en format XML
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Nemani</name></author><author><name sortKey="Nakamura, Ken" sort="Nakamura, Ken" uniqKey="Nakamura K" first="Ken" last="Nakamura">Ken Nakamura</name></author><author><name sortKey="Edwards, Robert H" sort="Edwards, Robert H" uniqKey="Edwards R" first="Robert H" last="Edwards">Robert H. Edwards</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22722</idno><idno type="RBID">pubmed:20187244</idno><idno type="pmid">20187244</idno><idno type="wicri:Area/PubMed/Corpus">001939</idno><idno type="wicri:Area/PubMed/Curation">001939</idno><idno type="wicri:Area/PubMed/Checkpoint">001575</idno><idno type="wicri:Area/Ncbi/Merge">002A63</idno><idno type="wicri:Area/Ncbi/Curation">002A63</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The behavior of alpha-synuclein in neurons.</title><author><name sortKey="Fortin, Doris L" sort="Fortin, Doris L" uniqKey="Fortin D" first="Doris L" last="Fortin">Doris L. Fortin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nemani, Venu M" sort="Nemani, Venu M" uniqKey="Nemani V" first="Venu M" last="Nemani">Venu M. Nemani</name></author><author><name sortKey="Nakamura, Ken" sort="Nakamura, Ken" uniqKey="Nakamura K" first="Ken" last="Nakamura">Ken Nakamura</name></author><author><name sortKey="Edwards, Robert H" sort="Edwards, Robert H" uniqKey="Edwards R" first="Robert H" last="Edwards">Robert H. Edwards</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcium (metabolism)</term><term>Humans</term><term>Mutation (genetics)</term><term>Neurons (metabolism)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>alpha-Synuclein (genetics)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite considerable evidence linking alpha-synuclein with membranes in vitro, it has proven difficult to demonstrate membrane association of the protein in vivo. alpha-Synuclein localizes to the nerve terminal, but biochemical experiments have not revealed a tight association with membranes. To address the dynamics of the protein in live cells, we have used photobleaching and found that alpha-synuclein exhibits high mobility, although distinctly less than an entirely soluble protein. Further, neural activity controls the distribution of alpha-synuclein, causing its dispersion from the synapse. In addition to the presumed role of alpha-synuclein dynamics in synaptic function, changes in its physiological behavior may underlie the pathological changes associated with Parkinson's disease.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Edwards, Robert H" sort="Edwards, Robert H" uniqKey="Edwards R" first="Robert H" last="Edwards">Robert H. Edwards</name><name sortKey="Nakamura, Ken" sort="Nakamura, Ken" uniqKey="Nakamura K" first="Ken" last="Nakamura">Ken Nakamura</name><name sortKey="Nemani, Venu M" sort="Nemani, Venu M" uniqKey="Nemani V" first="Venu M" last="Nemani">Venu M. Nemani</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Fortin, Doris L" sort="Fortin, Doris L" uniqKey="Fortin D" first="Doris L" last="Fortin">Doris L. Fortin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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