Thalamic single-unit and local field potential activity in Tourette syndrome.
Identifieur interne : 002A04 ( Ncbi/Checkpoint ); précédent : 002A03; suivant : 002A05Thalamic single-unit and local field potential activity in Tourette syndrome.
Auteurs : Sara Marceglia [Italie] ; Domenico Servello ; Guglielmo Foffani ; Mauro Porta ; Marco Sassi ; Simona Mrakic-Sposta ; Manuela Rosa ; Sergio Barbieri ; Alberto PrioriSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Action Potentials (physiology), Adult, Deep Brain Stimulation (methods), Evoked Potentials (physiology), Female, Humans, Male, Microelectrodes, Middle Aged, Neurons (physiology), Spectrum Analysis (methods), Thalamus (pathology), Thalamus (physiopathology), Tourette Syndrome (pathology), Tourette Syndrome (therapy), Young Adult.
- MESH :
- methods : Deep Brain Stimulation, Spectrum Analysis.
- pathology : Thalamus, Tourette Syndrome.
- physiology : Action Potentials, Evoked Potentials, Neurons.
- physiopathology : Thalamus.
- therapy : Tourette Syndrome.
- Adult, Female, Humans, Male, Microelectrodes, Middle Aged, Young Adult.
Abstract
Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the alpha-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.
DOI: 10.1002/mds.22982
PubMed: 20108375
Affiliations:
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Servello</name></author><author><name sortKey="Foffani, Guglielmo" sort="Foffani, Guglielmo" uniqKey="Foffani G" first="Guglielmo" last="Foffani">Guglielmo Foffani</name></author><author><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name></author><author><name sortKey="Sassi, Marco" sort="Sassi, Marco" uniqKey="Sassi M" first="Marco" last="Sassi">Marco Sassi</name></author><author><name sortKey="Mrakic Sposta, Simona" sort="Mrakic Sposta, Simona" uniqKey="Mrakic Sposta S" first="Simona" last="Mrakic-Sposta">Simona Mrakic-Sposta</name></author><author><name sortKey="Rosa, Manuela" sort="Rosa, Manuela" uniqKey="Rosa M" first="Manuela" last="Rosa">Manuela Rosa</name></author><author><name sortKey="Barbieri, Sergio" sort="Barbieri, Sergio" uniqKey="Barbieri S" first="Sergio" last="Barbieri">Sergio Barbieri</name></author><author><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" 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Maggiore, Policlinico, Mangiagalli e Regina Elena, Università di Milano, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centro Clinico per le Neuronanotecnologie e la Neurostimolazione, Fondazione IRCCS Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena, Università di Milano, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name></author><author><name sortKey="Foffani, Guglielmo" sort="Foffani, Guglielmo" uniqKey="Foffani G" first="Guglielmo" last="Foffani">Guglielmo Foffani</name></author><author><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name></author><author><name sortKey="Sassi, Marco" sort="Sassi, Marco" uniqKey="Sassi M" first="Marco" last="Sassi">Marco Sassi</name></author><author><name sortKey="Mrakic Sposta, Simona" sort="Mrakic Sposta, Simona" uniqKey="Mrakic Sposta S" first="Simona" last="Mrakic-Sposta">Simona Mrakic-Sposta</name></author><author><name sortKey="Rosa, Manuela" sort="Rosa, Manuela" uniqKey="Rosa M" first="Manuela" last="Rosa">Manuela Rosa</name></author><author><name sortKey="Barbieri, Sergio" sort="Barbieri, Sergio" uniqKey="Barbieri S" first="Sergio" last="Barbieri">Sergio Barbieri</name></author><author><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (physiology)</term><term>Adult</term><term>Deep Brain Stimulation (methods)</term><term>Evoked Potentials (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Microelectrodes</term><term>Middle Aged</term><term>Neurons (physiology)</term><term>Spectrum Analysis (methods)</term><term>Thalamus (pathology)</term><term>Thalamus (physiopathology)</term><term>Tourette Syndrome (pathology)</term><term>Tourette Syndrome (therapy)</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Spectrum Analysis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Thalamus</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Action Potentials</term><term>Evoked Potentials</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Microelectrodes</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the alpha-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Barbieri, Sergio" sort="Barbieri, Sergio" uniqKey="Barbieri S" first="Sergio" last="Barbieri">Sergio Barbieri</name><name sortKey="Foffani, Guglielmo" sort="Foffani, Guglielmo" uniqKey="Foffani G" first="Guglielmo" last="Foffani">Guglielmo Foffani</name><name sortKey="Mrakic Sposta, Simona" sort="Mrakic Sposta, Simona" uniqKey="Mrakic Sposta S" first="Simona" last="Mrakic-Sposta">Simona Mrakic-Sposta</name><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name><name sortKey="Rosa, Manuela" sort="Rosa, Manuela" uniqKey="Rosa M" first="Manuela" last="Rosa">Manuela Rosa</name><name sortKey="Sassi, Marco" sort="Sassi, Marco" uniqKey="Sassi M" first="Marco" last="Sassi">Marco Sassi</name><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name></noCountry><country name="Italie"><noRegion><name sortKey="Marceglia, Sara" sort="Marceglia, Sara" uniqKey="Marceglia S" first="Sara" last="Marceglia">Sara Marceglia</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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