Health-related quality of life in patients with Gilles de la Tourette's syndrome.
Identifieur interne : 002961 ( Ncbi/Checkpoint ); précédent : 002960; suivant : 002962Health-related quality of life in patients with Gilles de la Tourette's syndrome.
Auteurs : Kirsten Müller-Vahl [Allemagne] ; Ines Dodel ; Norbert Müller ; Alexander Münchau ; Jens Peter Reese ; Monika Balzer-Geldsetzer ; Richard Dodel ; Wolfgang H. OertelSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Age Factors, Female, Health Status, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Pain Measurement, Psychiatric Status Rating Scales, Quality of Life (psychology), Questionnaires, Self Care, Severity of Illness Index, Sex Factors, Tourette Syndrome (physiopathology), Tourette Syndrome (psychology).
- MESH :
- physiopathology : Tourette Syndrome.
- psychology : Quality of Life, Tourette Syndrome.
- Adult, Age Factors, Female, Health Status, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Pain Measurement, Psychiatric Status Rating Scales, Questionnaires, Self Care, Severity of Illness Index, Sex Factors.
Abstract
To investigate the health-related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 +/- 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi-structured, self-rating interview. HrQoL was measured using the EQ-5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette-syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self-care (6.6%). The mean EQ-5D visual analog scale (EQ-VAS) was 65.4 +/- 21.9. The patients had a mean BDI score of 12.3 +/- 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 +/- 5.2. The mean STSSS value was 3.2 +/- 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R(2) = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co-morbidities such as depression should be diagnosed and treated vigorously.
DOI: 10.1002/mds.22900
PubMed: 20063404
Affiliations:
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Oertel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22900</idno><idno type="RBID">pubmed:20063404</idno><idno type="pmid">20063404</idno><idno type="wicri:Area/PubMed/Corpus">001A41</idno><idno type="wicri:Area/PubMed/Curation">001A41</idno><idno type="wicri:Area/PubMed/Checkpoint">001854</idno><idno type="wicri:Area/Ncbi/Merge">002961</idno><idno type="wicri:Area/Ncbi/Curation">002961</idno><idno type="wicri:Area/Ncbi/Checkpoint">002961</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Health-related quality of life in patients with Gilles de la Tourette's syndrome.</title><author><name sortKey="Muller Vahl, Kirsten" sort="Muller Vahl, Kirsten" uniqKey="Muller Vahl K" first="Kirsten" last="Müller-Vahl">Kirsten Müller-Vahl</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School</wicri:regionArea><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Dodel, Ines" sort="Dodel, Ines" uniqKey="Dodel I" first="Ines" last="Dodel">Ines Dodel</name></author><author><name sortKey="Muller, Norbert" sort="Muller, Norbert" uniqKey="Muller N" first="Norbert" last="Müller">Norbert Müller</name></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name></author><author><name sortKey="Reese, Jens Peter" sort="Reese, Jens Peter" uniqKey="Reese J" first="Jens Peter" last="Reese">Jens Peter Reese</name></author><author><name sortKey="Balzer Geldsetzer, Monika" sort="Balzer Geldsetzer, Monika" uniqKey="Balzer Geldsetzer M" first="Monika" last="Balzer-Geldsetzer">Monika Balzer-Geldsetzer</name></author><author><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Female</term><term>Health Status</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment (Health Care)</term><term>Pain Measurement</term><term>Psychiatric Status Rating Scales</term><term>Quality of Life (psychology)</term><term>Questionnaires</term><term>Self Care</term><term>Severity of Illness Index</term><term>Sex Factors</term><term>Tourette Syndrome (physiopathology)</term><term>Tourette Syndrome (psychology)</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Quality of Life</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Female</term><term>Health Status</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment (Health Care)</term><term>Pain Measurement</term><term>Psychiatric Status Rating Scales</term><term>Questionnaires</term><term>Self Care</term><term>Severity of Illness Index</term><term>Sex Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the health-related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 +/- 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi-structured, self-rating interview. HrQoL was measured using the EQ-5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette-syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self-care (6.6%). The mean EQ-5D visual analog scale (EQ-VAS) was 65.4 +/- 21.9. The patients had a mean BDI score of 12.3 +/- 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 +/- 5.2. The mean STSSS value was 3.2 +/- 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R(2) = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co-morbidities such as depression should be diagnosed and treated vigorously.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Balzer Geldsetzer, Monika" sort="Balzer Geldsetzer, Monika" uniqKey="Balzer Geldsetzer M" first="Monika" last="Balzer-Geldsetzer">Monika Balzer-Geldsetzer</name><name sortKey="Dodel, Ines" sort="Dodel, Ines" uniqKey="Dodel I" first="Ines" last="Dodel">Ines Dodel</name><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name><name sortKey="Muller, Norbert" sort="Muller, Norbert" uniqKey="Muller N" first="Norbert" last="Müller">Norbert Müller</name><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name><name sortKey="Reese, Jens Peter" sort="Reese, Jens Peter" uniqKey="Reese J" first="Jens Peter" last="Reese">Jens Peter Reese</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Muller Vahl, Kirsten" sort="Muller Vahl, Kirsten" uniqKey="Muller Vahl K" first="Kirsten" last="Müller-Vahl">Kirsten Müller-Vahl</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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