No brain structure abnormalities in boys with Tourette's syndrome: a voxel-based morphometry study.
Identifieur interne : 002882 ( Ncbi/Checkpoint ); précédent : 002881; suivant : 002883No brain structure abnormalities in boys with Tourette's syndrome: a voxel-based morphometry study.
Auteurs : Veit Roessner [Allemagne] ; Sebastian Overlack ; Juergen Baudewig ; Peter Dechent ; Aribert Rothenberger ; Gunther HelmsSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- methods : Magnetic Resonance Imaging.
- pathology : Brain, Tourette Syndrome.
- Adolescent, Analysis of Variance, Brain Mapping, Child, Humans, Image Processing, Computer-Assisted, Male.
Abstract
Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). Our aim was to identify possible morphometric changes in a well-defined sample of drug-naïve boys with "pure" TS. High-resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel-based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10- to 15-year-old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with "pure" TS and healthy controls. Brain morphology is not altered in boys with "pure" TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long-term compensatory mechanisms due to voluntary tic suppression.
DOI: 10.1002/mds.22847
PubMed: 19890999
Affiliations:
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Computer-Assisted</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). Our aim was to identify possible morphometric changes in a well-defined sample of drug-naïve boys with "pure" TS. High-resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel-based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10- to 15-year-old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with "pure" TS and healthy controls. Brain morphology is not altered in boys with "pure" TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long-term compensatory mechanisms due to voluntary tic suppression.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Dresde</li><li>Saxe (Land)</li></region><settlement><li>Dresde</li></settlement></list><tree><noCountry><name sortKey="Baudewig, Juergen" sort="Baudewig, Juergen" uniqKey="Baudewig J" first="Juergen" last="Baudewig">Juergen Baudewig</name><name sortKey="Dechent, Peter" sort="Dechent, Peter" uniqKey="Dechent P" first="Peter" last="Dechent">Peter Dechent</name><name sortKey="Helms, Gunther" sort="Helms, Gunther" uniqKey="Helms G" first="Gunther" last="Helms">Gunther Helms</name><name sortKey="Overlack, Sebastian" sort="Overlack, Sebastian" uniqKey="Overlack S" first="Sebastian" last="Overlack">Sebastian Overlack</name><name sortKey="Rothenberger, Aribert" sort="Rothenberger, Aribert" uniqKey="Rothenberger A" first="Aribert" last="Rothenberger">Aribert Rothenberger</name></noCountry><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Roessner, Veit" sort="Roessner, Veit" uniqKey="Roessner V" first="Veit" last="Roessner">Veit Roessner</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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