Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder.
Identifieur interne : 002762 ( Ncbi/Checkpoint ); précédent : 002761; suivant : 002763Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder.
Auteurs : Heike Stockner [Autriche] ; Alex Iranzo ; Klaus Seppi ; M Nica Serradell ; Viola Gschliesser ; Martin Sojer ; Francesc Valldeoriola ; José L. Molinuevo ; Birgit Frauscher ; Christof Schmidauer ; Joan Santamaria ; Birgit Högl ; Eduardo Tolosa ; Werner Poewe [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Cohort Studies, Cross-Cultural Comparison, Female, Humans, International Cooperation, Male, Mesencephalon (pathology), Mesencephalon (ultrasonography), Middle Aged, Parkinson Disease (etiology), Parkinson Disease (ultrasonography), Psychiatric Status Rating Scales, REM Sleep Behavior Disorder (complications), REM Sleep Behavior Disorder (pathology), REM Sleep Behavior Disorder (ultrasonography), Ultrasonography, Doppler, Transcranial (methods).
- MESH :
- complications : REM Sleep Behavior Disorder.
- etiology : Parkinson Disease.
- methods : Ultrasonography, Doppler, Transcranial.
- pathology : Mesencephalon, REM Sleep Behavior Disorder.
- ultrasonography : Mesencephalon, Parkinson Disease, REM Sleep Behavior Disorder.
- Aged, Case-Control Studies, Cohort Studies, Cross-Cultural Comparison, Female, Humans, International Cooperation, Male, Middle Aged, Psychiatric Status Rating Scales.
Abstract
Recent studies have reported an increased risk to develop Parkinson's disease (PD) in patients with idiopathic RBD (iRBD). Midbrain hyperechogenicity is a common transcranial sonography (TCS) finding in PD and has been suggested as a PD risk-marker in nonparkinsonian subjects. The objective of this study is to assess midbrain echogenicity by TCS in patients with iRBD and compare the findings with the healthy controls. TCS was performed in 55 iRBD patients and in 165 age and sex-matched controls. The area of echogenicity in the SN region in the iRBD group was significantly increased compared with the control group (P < 0.001). About 19 (37.3%) of patients with iRBD were found to have SN hyperechogenicity when compared with 16 (10.7%) of the controls (P < 0.001). This is the first case-control study assessing midbrain echogenicity in a large iRBD cohort compared to age- and sex-matched healthy individuals. The finding of an increased prevalence of hyperechogenicity in a subgroup of individuals with a priori increased risk for PD supports the potential role of hyperechogenicity as a risk marker for PD. The prospective follow-up of this iRBD cohort is needed to establish if those with midbrain hyperechogenicity will go on to develop clinically defined PD or not.
DOI: 10.1002/mds.22483
PubMed: 19645057
Affiliations:
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<front><div type="abstract" xml:lang="en">Recent studies have reported an increased risk to develop Parkinson's disease (PD) in patients with idiopathic RBD (iRBD). Midbrain hyperechogenicity is a common transcranial sonography (TCS) finding in PD and has been suggested as a PD risk-marker in nonparkinsonian subjects. The objective of this study is to assess midbrain echogenicity by TCS in patients with iRBD and compare the findings with the healthy controls. TCS was performed in 55 iRBD patients and in 165 age and sex-matched controls. The area of echogenicity in the SN region in the iRBD group was significantly increased compared with the control group (P < 0.001). About 19 (37.3%) of patients with iRBD were found to have SN hyperechogenicity when compared with 16 (10.7%) of the controls (P < 0.001). This is the first case-control study assessing midbrain echogenicity in a large iRBD cohort compared to age- and sex-matched healthy individuals. The finding of an increased prevalence of hyperechogenicity in a subgroup of individuals with a priori increased risk for PD supports the potential role of hyperechogenicity as a risk marker for PD. The prospective follow-up of this iRBD cohort is needed to establish if those with midbrain hyperechogenicity will go on to develop clinically defined PD or not.</div>
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