Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder.
Identifieur interne : 002762 ( Ncbi/Checkpoint ); précédent : 002761; suivant : 002763Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder.
Auteurs : Heike Stockner [Autriche] ; Alex Iranzo ; Klaus Seppi ; M Nica Serradell ; Viola Gschliesser ; Martin Sojer ; Francesc Valldeoriola ; José L. Molinuevo ; Birgit Frauscher ; Christof Schmidauer ; Joan Santamaria ; Birgit Högl ; Eduardo Tolosa ; Werner Poewe [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Cohort Studies, Cross-Cultural Comparison, Female, Humans, International Cooperation, Male, Mesencephalon (pathology), Mesencephalon (ultrasonography), Middle Aged, Parkinson Disease (etiology), Parkinson Disease (ultrasonography), Psychiatric Status Rating Scales, REM Sleep Behavior Disorder (complications), REM Sleep Behavior Disorder (pathology), REM Sleep Behavior Disorder (ultrasonography), Ultrasonography, Doppler, Transcranial (methods).
- MESH :
- complications : REM Sleep Behavior Disorder.
- etiology : Parkinson Disease.
- methods : Ultrasonography, Doppler, Transcranial.
- pathology : Mesencephalon, REM Sleep Behavior Disorder.
- ultrasonography : Mesencephalon, Parkinson Disease, REM Sleep Behavior Disorder.
- Aged, Case-Control Studies, Cohort Studies, Cross-Cultural Comparison, Female, Humans, International Cooperation, Male, Middle Aged, Psychiatric Status Rating Scales.
Abstract
Recent studies have reported an increased risk to develop Parkinson's disease (PD) in patients with idiopathic RBD (iRBD). Midbrain hyperechogenicity is a common transcranial sonography (TCS) finding in PD and has been suggested as a PD risk-marker in nonparkinsonian subjects. The objective of this study is to assess midbrain echogenicity by TCS in patients with iRBD and compare the findings with the healthy controls. TCS was performed in 55 iRBD patients and in 165 age and sex-matched controls. The area of echogenicity in the SN region in the iRBD group was significantly increased compared with the control group (P < 0.001). About 19 (37.3%) of patients with iRBD were found to have SN hyperechogenicity when compared with 16 (10.7%) of the controls (P < 0.001). This is the first case-control study assessing midbrain echogenicity in a large iRBD cohort compared to age- and sex-matched healthy individuals. The finding of an increased prevalence of hyperechogenicity in a subgroup of individuals with a priori increased risk for PD supports the potential role of hyperechogenicity as a risk marker for PD. The prospective follow-up of this iRBD cohort is needed to establish if those with midbrain hyperechogenicity will go on to develop clinically defined PD or not.
DOI: 10.1002/mds.22483
PubMed: 19645057
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001C15
- to stream PubMed, to step Curation: 001C15
- to stream PubMed, to step Checkpoint: 001D21
- to stream Ncbi, to step Merge: 002762
- to stream Ncbi, to step Curation: 002762
Links to Exploration step
pubmed:19645057Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder.</title><author><name sortKey="Stockner, Heike" sort="Stockner, Heike" uniqKey="Stockner H" first="Heike" last="Stockner">Heike Stockner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck 6020, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Innsbruck, Innsbruck 6020</wicri:regionArea><wicri:noRegion>Innsbruck 6020</wicri:noRegion></affiliation></author><author><name sortKey="Iranzo, Alex" sort="Iranzo, Alex" uniqKey="Iranzo A" first="Alex" last="Iranzo">Alex Iranzo</name></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></author><author><name sortKey="Serradell, M Nica" sort="Serradell, M Nica" uniqKey="Serradell M" first="M Nica" last="Serradell">M Nica Serradell</name></author><author><name sortKey="Gschliesser, Viola" sort="Gschliesser, Viola" uniqKey="Gschliesser V" first="Viola" last="Gschliesser">Viola Gschliesser</name></author><author><name sortKey="Sojer, Martin" sort="Sojer, Martin" uniqKey="Sojer M" first="Martin" last="Sojer">Martin Sojer</name></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Molinuevo, Jose L" sort="Molinuevo, Jose L" uniqKey="Molinuevo J" first="José L" last="Molinuevo">José L. Molinuevo</name></author><author><name sortKey="Frauscher, Birgit" sort="Frauscher, Birgit" uniqKey="Frauscher B" first="Birgit" last="Frauscher">Birgit Frauscher</name></author><author><name sortKey="Schmidauer, Christof" sort="Schmidauer, Christof" uniqKey="Schmidauer C" first="Christof" last="Schmidauer">Christof Schmidauer</name></author><author><name sortKey="Santamaria, Joan" sort="Santamaria, Joan" uniqKey="Santamaria J" first="Joan" last="Santamaria">Joan Santamaria</name></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22483</idno><idno type="RBID">pubmed:19645057</idno><idno type="pmid">19645057</idno><idno type="wicri:Area/PubMed/Corpus">001C15</idno><idno type="wicri:Area/PubMed/Curation">001C15</idno><idno type="wicri:Area/PubMed/Checkpoint">001D21</idno><idno type="wicri:Area/Ncbi/Merge">002762</idno><idno type="wicri:Area/Ncbi/Curation">002762</idno><idno type="wicri:Area/Ncbi/Checkpoint">002762</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder.</title><author><name sortKey="Stockner, Heike" sort="Stockner, Heike" uniqKey="Stockner H" first="Heike" last="Stockner">Heike Stockner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck 6020, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Innsbruck, Innsbruck 6020</wicri:regionArea><wicri:noRegion>Innsbruck 6020</wicri:noRegion></affiliation></author><author><name sortKey="Iranzo, Alex" sort="Iranzo, Alex" uniqKey="Iranzo A" first="Alex" last="Iranzo">Alex Iranzo</name></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></author><author><name sortKey="Serradell, M Nica" sort="Serradell, M Nica" uniqKey="Serradell M" first="M Nica" last="Serradell">M Nica Serradell</name></author><author><name sortKey="Gschliesser, Viola" sort="Gschliesser, Viola" uniqKey="Gschliesser V" first="Viola" last="Gschliesser">Viola Gschliesser</name></author><author><name sortKey="Sojer, Martin" sort="Sojer, Martin" uniqKey="Sojer M" first="Martin" last="Sojer">Martin Sojer</name></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Molinuevo, Jose L" sort="Molinuevo, Jose L" uniqKey="Molinuevo J" first="José L" last="Molinuevo">José L. Molinuevo</name></author><author><name sortKey="Frauscher, Birgit" sort="Frauscher, Birgit" uniqKey="Frauscher B" first="Birgit" last="Frauscher">Birgit Frauscher</name></author><author><name sortKey="Schmidauer, Christof" sort="Schmidauer, Christof" uniqKey="Schmidauer C" first="Christof" last="Schmidauer">Christof Schmidauer</name></author><author><name sortKey="Santamaria, Joan" sort="Santamaria, Joan" uniqKey="Santamaria J" first="Joan" last="Santamaria">Joan Santamaria</name></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Cross-Cultural Comparison</term><term>Female</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Mesencephalon (pathology)</term><term>Mesencephalon (ultrasonography)</term><term>Middle Aged</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (ultrasonography)</term><term>Psychiatric Status Rating Scales</term><term>REM Sleep Behavior Disorder (complications)</term><term>REM Sleep Behavior Disorder (pathology)</term><term>REM Sleep Behavior Disorder (ultrasonography)</term><term>Ultrasonography, Doppler, Transcranial (methods)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Ultrasonography, Doppler, Transcranial</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Mesencephalon</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Mesencephalon</term><term>Parkinson Disease</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Cross-Cultural Comparison</term><term>Female</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Psychiatric Status Rating Scales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies have reported an increased risk to develop Parkinson's disease (PD) in patients with idiopathic RBD (iRBD). Midbrain hyperechogenicity is a common transcranial sonography (TCS) finding in PD and has been suggested as a PD risk-marker in nonparkinsonian subjects. The objective of this study is to assess midbrain echogenicity by TCS in patients with iRBD and compare the findings with the healthy controls. TCS was performed in 55 iRBD patients and in 165 age and sex-matched controls. The area of echogenicity in the SN region in the iRBD group was significantly increased compared with the control group (P < 0.001). About 19 (37.3%) of patients with iRBD were found to have SN hyperechogenicity when compared with 16 (10.7%) of the controls (P < 0.001). This is the first case-control study assessing midbrain echogenicity in a large iRBD cohort compared to age- and sex-matched healthy individuals. The finding of an increased prevalence of hyperechogenicity in a subgroup of individuals with a priori increased risk for PD supports the potential role of hyperechogenicity as a risk marker for PD. The prospective follow-up of this iRBD cohort is needed to establish if those with midbrain hyperechogenicity will go on to develop clinically defined PD or not.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><noCountry><name sortKey="Frauscher, Birgit" sort="Frauscher, Birgit" uniqKey="Frauscher B" first="Birgit" last="Frauscher">Birgit Frauscher</name><name sortKey="Gschliesser, Viola" sort="Gschliesser, Viola" uniqKey="Gschliesser V" first="Viola" last="Gschliesser">Viola Gschliesser</name><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name><name sortKey="Iranzo, Alex" sort="Iranzo, Alex" uniqKey="Iranzo A" first="Alex" last="Iranzo">Alex Iranzo</name><name sortKey="Molinuevo, Jose L" sort="Molinuevo, Jose L" uniqKey="Molinuevo J" first="José L" last="Molinuevo">José L. Molinuevo</name><name sortKey="Santamaria, Joan" sort="Santamaria, Joan" uniqKey="Santamaria J" first="Joan" last="Santamaria">Joan Santamaria</name><name sortKey="Schmidauer, Christof" sort="Schmidauer, Christof" uniqKey="Schmidauer C" first="Christof" last="Schmidauer">Christof Schmidauer</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><name sortKey="Serradell, M Nica" sort="Serradell, M Nica" uniqKey="Serradell M" first="M Nica" last="Serradell">M Nica Serradell</name><name sortKey="Sojer, Martin" sort="Sojer, Martin" uniqKey="Sojer M" first="Martin" last="Sojer">Martin Sojer</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></noCountry><country name="Autriche"><noRegion><name sortKey="Stockner, Heike" sort="Stockner, Heike" uniqKey="Stockner H" first="Heike" last="Stockner">Heike Stockner</name></noRegion><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002762 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 002762 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:19645057
|texte= Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:19645057" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |