Parsing brain activity associated with acupuncture treatment in Parkinson's diseases.
Identifieur interne : 002727 ( Ncbi/Checkpoint ); précédent : 002726; suivant : 002728Parsing brain activity associated with acupuncture treatment in Parkinson's diseases.
Auteurs : Younbyoung Chae [Corée du Sud] ; Hyejung Lee ; Hackjin Kim ; Chang-Hwan Kim ; Dae-Il Chang ; Kyung-Mi Kim ; Hi-Joon ParkSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Acupuncture Therapy (methods), Adult, Aged, Brain (blood supply), Brain (physiopathology), Brain Mapping, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Oxygen (blood), Parkinson Disease (pathology), Parkinson Disease (therapy), Psychomotor Performance (physiology), Severity of Illness Index.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Brain.
- methods : Acupuncture Therapy, Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Parkinson Disease.
- physiology : Psychomotor Performance.
- physiopathology : Brain.
- therapy : Parkinson Disease.
- Adult, Aged, Brain Mapping, Double-Blind Method, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood-oxygen-level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia-thalamocortical circuit.
DOI: 10.1002/mds.22673
PubMed: 19533753
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parsing brain activity associated with acupuncture treatment in Parkinson's diseases.</title><author><name sortKey="Chae, Younbyoung" sort="Chae, Younbyoung" uniqKey="Chae Y" first="Younbyoung" last="Chae">Younbyoung Chae</name><affiliation wicri:level="3"><nlm:affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun-gu, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Hyejung" sort="Lee, Hyejung" uniqKey="Lee H" first="Hyejung" last="Lee">Hyejung Lee</name></author><author><name sortKey="Kim, Hackjin" sort="Kim, Hackjin" uniqKey="Kim H" first="Hackjin" last="Kim">Hackjin Kim</name></author><author><name sortKey="Kim, Chang Hwan" sort="Kim, Chang Hwan" uniqKey="Kim C" first="Chang-Hwan" last="Kim">Chang-Hwan Kim</name></author><author><name sortKey="Chang, Dae Il" sort="Chang, Dae Il" uniqKey="Chang D" first="Dae-Il" last="Chang">Dae-Il Chang</name></author><author><name sortKey="Kim, Kyung Mi" sort="Kim, Kyung Mi" uniqKey="Kim K" first="Kyung-Mi" last="Kim">Kyung-Mi Kim</name></author><author><name sortKey="Park, Hi Joon" sort="Park, Hi Joon" uniqKey="Park H" first="Hi-Joon" last="Park">Hi-Joon Park</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22673</idno><idno type="RBID">pubmed:19533753</idno><idno type="pmid">19533753</idno><idno type="wicri:Area/PubMed/Corpus">001C50</idno><idno type="wicri:Area/PubMed/Curation">001C50</idno><idno type="wicri:Area/PubMed/Checkpoint">001C49</idno><idno type="wicri:Area/Ncbi/Merge">002727</idno><idno type="wicri:Area/Ncbi/Curation">002727</idno><idno type="wicri:Area/Ncbi/Checkpoint">002727</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Parsing brain activity associated with acupuncture treatment in Parkinson's diseases.</title><author><name sortKey="Chae, Younbyoung" sort="Chae, Younbyoung" uniqKey="Chae Y" first="Younbyoung" last="Chae">Younbyoung Chae</name><affiliation wicri:level="3"><nlm:affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun-gu, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Hyejung" sort="Lee, Hyejung" uniqKey="Lee H" first="Hyejung" last="Lee">Hyejung Lee</name></author><author><name sortKey="Kim, Hackjin" sort="Kim, Hackjin" uniqKey="Kim H" first="Hackjin" last="Kim">Hackjin Kim</name></author><author><name sortKey="Kim, Chang Hwan" sort="Kim, Chang Hwan" uniqKey="Kim C" first="Chang-Hwan" last="Kim">Chang-Hwan Kim</name></author><author><name sortKey="Chang, Dae Il" sort="Chang, Dae Il" uniqKey="Chang D" first="Dae-Il" last="Chang">Dae-Il Chang</name></author><author><name sortKey="Kim, Kyung Mi" sort="Kim, Kyung Mi" uniqKey="Kim K" first="Kyung-Mi" last="Kim">Kyung-Mi Kim</name></author><author><name sortKey="Park, Hi Joon" sort="Park, Hi Joon" uniqKey="Park H" first="Hi-Joon" last="Park">Hi-Joon Park</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acupuncture Therapy (methods)</term><term>Adult</term><term>Aged</term><term>Brain (blood supply)</term><term>Brain (physiopathology)</term><term>Brain Mapping</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Oxygen (blood)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (therapy)</term><term>Psychomotor Performance (physiology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Acupuncture Therapy</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood-oxygen-level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia-thalamocortical circuit.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Chang, Dae Il" sort="Chang, Dae Il" uniqKey="Chang D" first="Dae-Il" last="Chang">Dae-Il Chang</name><name sortKey="Kim, Chang Hwan" sort="Kim, Chang Hwan" uniqKey="Kim C" first="Chang-Hwan" last="Kim">Chang-Hwan Kim</name><name sortKey="Kim, Hackjin" sort="Kim, Hackjin" uniqKey="Kim H" first="Hackjin" last="Kim">Hackjin Kim</name><name sortKey="Kim, Kyung Mi" sort="Kim, Kyung Mi" uniqKey="Kim K" first="Kyung-Mi" last="Kim">Kyung-Mi Kim</name><name sortKey="Lee, Hyejung" sort="Lee, Hyejung" uniqKey="Lee H" first="Hyejung" last="Lee">Hyejung Lee</name><name sortKey="Park, Hi Joon" sort="Park, Hi Joon" uniqKey="Park H" first="Hi-Joon" last="Park">Hi-Joon Park</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Chae, Younbyoung" sort="Chae, Younbyoung" uniqKey="Chae Y" first="Younbyoung" last="Chae">Younbyoung Chae</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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