Effect of Movement Frequency on Repetitive Finger Movements in Patients with Parkinson's Disease
Identifieur interne : 002649 ( Ncbi/Checkpoint ); précédent : 002648; suivant : 002650Effect of Movement Frequency on Repetitive Finger Movements in Patients with Parkinson's Disease
Auteurs : Elizabeth L. Stegemöller [États-Unis] ; Tanya Simuni [États-Unis] ; Colum Mackinnon [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2009.
English descriptors
- KwdEn :
- Acoustic Stimulation (methods), Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Electromyography (methods), Female, Fingers (physiopathology), Humans, Male, Middle Aged, Movement (drug effects), Movement (physiology), Oscillometry, Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Spectrum Analysis (methods).
- MESH :
- chemical , pharmacology : Antiparkinson Agents.
- drug effects : Movement, Psychomotor Performance.
- drug therapy : Parkinson Disease.
- methods : Acoustic Stimulation, Electromyography, Spectrum Analysis.
- pathology : Parkinson Disease.
- physiology : Movement, Psychomotor Performance.
- physiopathology : Fingers, Parkinson Disease.
- chemical , therapeutic use : Antiparkinson Agents.
- Aged, Female, Humans, Male, Middle Aged, Oscillometry.
Abstract
Performance of repetitive hand movements in patients with Parkinson's disease (PD) is characterized by slowness, reduced movement amplitude, and hesitation or arrests in ongoing movement. Currently, the factors and mechanisms contributing to impaired performance of these types of movement remain poorly understood. This study examined the effects of movement frequency and medication on the performance of unconstrained index finger flexion movements in patients with PD and matched control subjects. Movements were synchronized with an auditory tone as the frequency of the tone was increased from 1 to 3 Hz in 0.25 Hz increments. Movement performance was quantified based upon finger kinematics and electromyography (EMG) recorded from the index finger flexors and extensors. The principal finding was that patients with PD showed a dramatic reduction in movement amplitude, an increase in movement frequency, and a loss of phase when the movement frequency reached or exceeded 2 Hz. This deficit was not significantly improved with medications. In contrast, all control subjects could synchronize to 3 Hz. These findings show that movement frequency is a major determinant of hypokinesia during repetitive movements and may contribute to hesitations and movement arrest during clinical testing of bradykinesia in the upper limb of patients with PD.
Url:
DOI: 10.1002/mds.22535
PubMed: 19412952
PubMed Central: 2754052
Affiliations:
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PMC:2754052Le document en format XML
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Stegemöller</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Mackinnon, Colum" sort="Mackinnon, Colum" uniqKey="Mackinnon C" first="Colum" last="Mackinnon">Colum Mackinnon</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation (methods)</term><term>Aged</term><term>Antiparkinson Agents (pharmacology)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Electromyography (methods)</term><term>Female</term><term>Fingers (physiopathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement (drug effects)</term><term>Movement (physiology)</term><term>Oscillometry</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term><term>Spectrum Analysis (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Acoustic Stimulation</term><term>Electromyography</term><term>Spectrum Analysis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Fingers</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Oscillometry</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Performance of repetitive hand movements in patients with Parkinson's disease (PD) is characterized by slowness, reduced movement amplitude, and hesitation or arrests in ongoing movement. Currently, the factors and mechanisms contributing to impaired performance of these types of movement remain poorly understood. This study examined the effects of movement frequency and medication on the performance of unconstrained index finger flexion movements in patients with PD and matched control subjects. Movements were synchronized with an auditory tone as the frequency of the tone was increased from 1 to 3 Hz in 0.25 Hz increments. Movement performance was quantified based upon finger kinematics and electromyography (EMG) recorded from the index finger flexors and extensors. The principal finding was that patients with PD showed a dramatic reduction in movement amplitude, an increase in movement frequency, and a loss of phase when the movement frequency reached or exceeded 2 Hz. This deficit was not significantly improved with medications. In contrast, all control subjects could synchronize to 3 Hz. These findings show that movement frequency is a major determinant of hypokinesia during repetitive movements and may contribute to hesitations and movement arrest during clinical testing of bradykinesia in the upper limb of patients with PD.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Stegemoller, Elizabeth L" sort="Stegemoller, Elizabeth L" uniqKey="Stegemoller E" first="Elizabeth L." last="Stegemöller">Elizabeth L. Stegemöller</name></region><name sortKey="Mackinnon, Colum" sort="Mackinnon, Colum" uniqKey="Mackinnon C" first="Colum" last="Mackinnon">Colum Mackinnon</name><name sortKey="Mackinnon, Colum" sort="Mackinnon, Colum" uniqKey="Mackinnon C" first="Colum" last="Mackinnon">Colum Mackinnon</name><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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