Cysteine elevation in levodopa-treated patients with Parkinson's disease.
Identifieur interne : 002582 ( Ncbi/Checkpoint ); précédent : 002581; suivant : 002583Cysteine elevation in levodopa-treated patients with Parkinson's disease.
Auteurs : Thomas Müller [Allemagne] ; Wilfried KuhnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Cysteine, Glycine.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood : Parkinson Disease.
- drug therapy : Parkinson Disease.
- Adult, Aged, Analysis of Variance, Cohort Studies, Female, Humans, Linear Models, Male, Middle Aged, Severity of Illness Index.
Abstract
Homocysteine, cysteine, and cysteinyl-glycine are all metabolically interrelated. Levodopa/decarboxylase inhibitor (LD/DCI) administration increases total homocysteine (tHcy) plasma levels. Objectives were to investigate associations between LD/DCI intake, concentrations of tHcy, cysteine, and cysteinyl-glycine in PD patients and healthy controls. Cysteine levels were significant lower in controls and PD patients with tHcy below the treshold of 15 [micromol/L] when compared with PD patients with tHcy above 15. Cysteinyl-glycine did not significantly differ between the three cohorts. Significant associations appeared between tHcys and cysteine in PD patients. tHcy and cysteine concentrations correlated to LD/DCI intake and severity of PD. The cysteine increase may be due to the significant higher dosing of daily LD/DCI and the significant higher morning LD/DCI dose 1 hour before blood sampling in PD patients with tHcy above 15 when compared with the remaining PD patients and the controls. The correlation outcomes support the view that LD/DCI intake may also increase cysteine.
DOI: 10.1002/mds.22482
PubMed: 19243072
Affiliations:
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pubmed:19243072Le document en format XML
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<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstrasse 1, Berlin,Germany. th.mueller@alexius.de or</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstrasse 1, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
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<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstrasse 1, Berlin,Germany. th.mueller@alexius.de or</nlm:affiliation>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Aged</term>
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<term>Antiparkinson Agents (therapeutic use)</term>
<term>Cohort Studies</term>
<term>Cysteine (blood)</term>
<term>Female</term>
<term>Glycine (blood)</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Linear Models</term>
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<term>Parkinson Disease (blood)</term>
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<term>Severity of Illness Index</term>
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<front><div type="abstract" xml:lang="en">Homocysteine, cysteine, and cysteinyl-glycine are all metabolically interrelated. Levodopa/decarboxylase inhibitor (LD/DCI) administration increases total homocysteine (tHcy) plasma levels. Objectives were to investigate associations between LD/DCI intake, concentrations of tHcy, cysteine, and cysteinyl-glycine in PD patients and healthy controls. Cysteine levels were significant lower in controls and PD patients with tHcy below the treshold of 15 [micromol/L] when compared with PD patients with tHcy above 15. Cysteinyl-glycine did not significantly differ between the three cohorts. Significant associations appeared between tHcys and cysteine in PD patients. tHcy and cysteine concentrations correlated to LD/DCI intake and severity of PD. The cysteine increase may be due to the significant higher dosing of daily LD/DCI and the significant higher morning LD/DCI dose 1 hour before blood sampling in PD patients with tHcy above 15 when compared with the remaining PD patients and the controls. The correlation outcomes support the view that LD/DCI intake may also increase cysteine.</div>
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<affiliations><list><country><li>Allemagne</li>
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