MovDisordV3, Ncbi, Checkpoint, bibRecord, 002582

Cysteine elevation in levodopa-treated patients with Parkinson's disease.

Identifieur interne : 002582 ( Ncbi/Checkpoint ); précédent : 002581; suivant : 002583

Cysteine elevation in levodopa-treated patients with Parkinson's disease.

Auteurs : Thomas Müller [Allemagne] ; Wilfried Kuhn

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.

RBID : pubmed:19243072

English descriptors

KwdEn :
- Adult, Aged, Analysis of Variance, Antiparkinson Agents (therapeutic use), Cohort Studies, Cysteine (blood), Female, Glycine (blood), Humans, Levodopa (therapeutic use), Linear Models, Male, Middle Aged, Parkinson Disease (blood), Parkinson Disease (drug therapy), Severity of Illness Index.
MESH :
- chemical , blood : Cysteine, Glycine.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood : Parkinson Disease.
- drug therapy : Parkinson Disease.
- Adult, Aged, Analysis of Variance, Cohort Studies, Female, Humans, Linear Models, Male, Middle Aged, Severity of Illness Index.

Abstract

Homocysteine, cysteine, and cysteinyl-glycine are all metabolically interrelated. Levodopa/decarboxylase inhibitor (LD/DCI) administration increases total homocysteine (tHcy) plasma levels. Objectives were to investigate associations between LD/DCI intake, concentrations of tHcy, cysteine, and cysteinyl-glycine in PD patients and healthy controls. Cysteine levels were significant lower in controls and PD patients with tHcy below the treshold of 15 [micromol/L] when compared with PD patients with tHcy above 15. Cysteinyl-glycine did not significantly differ between the three cohorts. Significant associations appeared between tHcys and cysteine in PD patients. tHcy and cysteine concentrations correlated to LD/DCI intake and severity of PD. The cysteine increase may be due to the significant higher dosing of daily LD/DCI and the significant higher morning LD/DCI dose 1 hour before blood sampling in PD patients with tHcy above 15 when compared with the remaining PD patients and the controls. The correlation outcomes support the view that LD/DCI intake may also increase cysteine.

DOI: 10.1002/mds.22482
PubMed: 19243072

Affiliations:

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pubmed:19243072

Le document en format XML

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<author><name sortKey="Muller, Thomas" sort="Muller, Thomas" uniqKey="Muller T" first="Thomas" last="Müller">Thomas Müller</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstrasse 1, Berlin,Germany. th.mueller@alexius.de or</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstrasse 1, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
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<author><name sortKey="Kuhn, Wilfried" sort="Kuhn, Wilfried" uniqKey="Kuhn W" first="Wilfried" last="Kuhn">Wilfried Kuhn</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Cysteine elevation in levodopa-treated patients with Parkinson's disease.</title>
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<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstrasse 1, Berlin,Germany. th.mueller@alexius.de or</nlm:affiliation>
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<wicri:regionArea>Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstrasse 1, Berlin</wicri:regionArea>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Analysis of Variance</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Cohort Studies</term>
<term>Cysteine (blood)</term>
<term>Female</term>
<term>Glycine (blood)</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Linear Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (blood)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Severity of Illness Index</term>
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<term>Glycine</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Analysis of Variance</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Linear Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
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<front><div type="abstract" xml:lang="en">Homocysteine, cysteine, and cysteinyl-glycine are all metabolically interrelated. Levodopa/decarboxylase inhibitor (LD/DCI) administration increases total homocysteine (tHcy) plasma levels. Objectives were to investigate associations between LD/DCI intake, concentrations of tHcy, cysteine, and cysteinyl-glycine in PD patients and healthy controls. Cysteine levels were significant lower in controls and PD patients with tHcy below the treshold of 15 [micromol/L] when compared with PD patients with tHcy above 15. Cysteinyl-glycine did not significantly differ between the three cohorts. Significant associations appeared between tHcys and cysteine in PD patients. tHcy and cysteine concentrations correlated to LD/DCI intake and severity of PD. The cysteine increase may be due to the significant higher dosing of daily LD/DCI and the significant higher morning LD/DCI dose 1 hour before blood sampling in PD patients with tHcy above 15 when compared with the remaining PD patients and the controls. The correlation outcomes support the view that LD/DCI intake may also increase cysteine.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Berlin</li>
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<settlement><li>Berlin</li>
</settlement>
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<tree><noCountry><name sortKey="Kuhn, Wilfried" sort="Kuhn, Wilfried" uniqKey="Kuhn W" first="Wilfried" last="Kuhn">Wilfried Kuhn</name>
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<country name="Allemagne"><region name="Berlin"><name sortKey="Muller, Thomas" sort="Muller, Thomas" uniqKey="Muller T" first="Thomas" last="Müller">Thomas Müller</name>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Cysteine elevation in levodopa-treated patients with Parkinson's disease.

Cysteine elevation in levodopa-treated patients with Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki