MovDisordV3, Ncbi, Checkpoint, bibRecord, 002432

Gait and Balance in Essential Tremor: Variable Effects of Bilateral Thalamic Stimulation

Identifieur interne : 002432 ( Ncbi/Checkpoint ); précédent : 002431; suivant : 002433

Gait and Balance in Essential Tremor: Variable Effects of Bilateral Thalamic Stimulation

Auteurs : Gammon M. Earhart [États-Unis] ; B. Ruth Clark [États-Unis] ; Samer D. Tabbal [États-Unis] ; Joel S. Perlmutter [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2009.

RBID : PMC:2882155

English descriptors

KwdEn :
- Adult, Aged, Deep Brain Stimulation (methods), Essential Tremor (epidemiology), Essential Tremor (physiopathology), Essential Tremor (therapy), Female, Gait Disorders, Neurologic (epidemiology), Gait Disorders, Neurologic (physiopathology), Gait Disorders, Neurologic (therapy), Humans, Male, Middle Aged, Postural Balance (physiology), Severity of Illness Index, Thalamus (physiopathology), Treatment Outcome.
MESH :
- epidemiology : Essential Tremor, Gait Disorders, Neurologic.
- methods : Deep Brain Stimulation.
- physiology : Postural Balance.
- physiopathology : Essential Tremor, Gait Disorders, Neurologic, Thalamus.
- therapy : Essential Tremor, Gait Disorders, Neurologic.
- Adult, Aged, Female, Humans, Male, Middle Aged, Severity of Illness Index, Treatment Outcome.

Abstract

Essential tremor (ET) is a multi-faceted condition best known for postural and action tremor but also may include disordered gait and postural instability. Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) of the thalamus provides substantial tremor reduction yet some patients with bilateral VIM DBS have gait and balance impairment. This study examines gait and balance performance in 13 participants with ET who have bilateral VIM DBS compared to a matched control group. Participants with ET were tested with their stimulators off (DBS OFF) and on (DBS ON). For both standard and tandem walking, participants with ET walked significantly more slowly than controls, with significantly lower cadence, spending a lower percentage of the gait cycle in single limb support and a higher percentage in double support compared to controls. Participants with ET also had significantly lower tandem and one leg stance times, Berg balance scores, balance confidence, and required significantly greater time to perform the Timed Up-and-Go relative to controls. There were no significant differences in any gait or balance measures in the DBS OFF versus DBS ON conditions, but the effects of DBS on gait and balance were highly variable among individuals. Future studies are needed to determine why some individuals experience gait and balance difficulties after bilateral thalamic DBS and others do not. A better understanding of the mechanisms underlying gait and balance impairments in those with bilateral DBS is critical in order to reduce falls and fractures in this group.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882155

DOI: 10.1002/mds.22356
PubMed: 19006189
PubMed Central: 2882155

Affiliations:

Links to Exploration step

PMC:2882155

Le document en format XML

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<term>Female</term>
<term>Gait Disorders, Neurologic (epidemiology)</term>
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<term>Gait Disorders, Neurologic (therapy)</term>
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<term>Male</term>
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<term>Thalamus (physiopathology)</term>
<term>Treatment Outcome</term>
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<term>Female</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Essential tremor (ET) is a multi-faceted condition best known for postural and action tremor but also may include disordered gait and postural instability. Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) of the thalamus provides substantial tremor reduction yet some patients with bilateral VIM DBS have gait and balance impairment. This study examines gait and balance performance in 13 participants with ET who have bilateral VIM DBS compared to a matched control group. Participants with ET were tested with their stimulators off (DBS OFF) and on (DBS ON). For both standard and tandem walking, participants with ET walked significantly more slowly than controls, with significantly lower cadence, spending a lower percentage of the gait cycle in single limb support and a higher percentage in double support compared to controls. Participants with ET also had significantly lower tandem and one leg stance times, Berg balance scores, balance confidence, and required significantly greater time to perform the Timed Up-and-Go relative to controls. There were no significant differences in any gait or balance measures in the DBS OFF versus DBS ON conditions, but the effects of DBS on gait and balance were highly variable among individuals. Future studies are needed to determine why some individuals experience gait and balance difficulties after bilateral thalamic DBS and others do not. A better understanding of the mechanisms underlying gait and balance impairments in those with bilateral DBS is critical in order to reduce falls and fractures in this group.</p>
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Movement Disorders (revue)

Gait and Balance in Essential Tremor: Variable Effects of Bilateral Thalamic Stimulation

Gait and Balance in Essential Tremor: Variable Effects of Bilateral Thalamic Stimulation

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.