Parkinsonism and dystonia caused by the illicit use of ephedrone--a longitudinal study.
Identifieur interne : 002331 ( Ncbi/Checkpoint ); précédent : 002330; suivant : 002332Parkinsonism and dystonia caused by the illicit use of ephedrone--a longitudinal study.
Auteurs : Marianna Selikhova [Royaume-Uni] ; Ljuda Fedoryshyn ; Yuri Matviyenko ; Irena Komnatska ; Marianna Kyrylchuk ; Lesrek Krolicki ; Andrzej Friedman ; Andrew Taylor ; H Rolf J Ger ; Andrew Lees ; Yanush SanotskySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Adolescent, Adult, Brain (pathology), Brain (radionuclide imaging), Dystonic Disorders (chemically induced), Dystonic Disorders (pathology), Dystonic Disorders (physiopathology), Dystonic Disorders (radionuclide imaging), Humans, Longitudinal Studies, Magnetic Resonance Imaging (methods), Male, Manganese (deficiency), Manganese (metabolism), Middle Aged, Neurologic Examination, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (pathology), Parkinsonian Disorders (physiopathology), Parkinsonian Disorders (radionuclide imaging), Propiophenones (poisoning), Street Drugs (poisoning), Tomography, Emission-Computed, Single-Photon (methods), Young Adult.
- MESH :
- chemical , deficiency : Manganese.
- chemically induced : Dystonic Disorders, Parkinsonian Disorders.
- chemical , metabolism : Manganese.
- methods : Magnetic Resonance Imaging, Tomography, Emission-Computed, Single-Photon.
- pathology : Brain, Dystonic Disorders, Parkinsonian Disorders.
- physiopathology : Dystonic Disorders, Parkinsonian Disorders.
- chemical , poisoning : Propiophenones, Street Drugs.
- radionuclide imaging : Brain, Dystonic Disorders, Parkinsonian Disorders.
- Adolescent, Adult, Humans, Longitudinal Studies, Male, Middle Aged, Neurologic Examination, Young Adult.
Abstract
A neurological syndrome characterized by levodopa unresponsive bradykinesia, retropulsion with falls backwards, dysarthria, gait disturbance, dystonia, and emotional lability was identified in 13 male opiate addicts following the prolonged intravenous use of ephedrone (methcathinone), a central nervous stimulant prepared from pseudoephedrine, potassium permanganate, and vinegar. The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were carried out. Pubic hair was sampled for manganese. The clinical and radiological picture closely resembled previous reports of chronic manganese poisoning and increased mean manganese level in pubic hair observed for at least 1 year after cessation of ephedrone. Odor identification was intact. Cognitive assessment showed a mild executive dysfunction and a mild depression. DaTSCANs were all normal. The neurological syndrome bears some similarities to PSP but differs from Parkinson's disease. Delayed neurological progression despite discontinuation of ephedrone occurred in one-third of cases. Ephedrone poisoning should be considered as a possible cause of secondary Parkinsonism in young adults, particularly from Eastern Europe.
DOI: 10.1002/mds.22290
PubMed: 18785245
Affiliations:
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Matviyenko</name></author><author><name sortKey="Komnatska, Irena" sort="Komnatska, Irena" uniqKey="Komnatska I" first="Irena" last="Komnatska">Irena Komnatska</name></author><author><name sortKey="Kyrylchuk, Marianna" sort="Kyrylchuk, Marianna" uniqKey="Kyrylchuk M" first="Marianna" last="Kyrylchuk">Marianna Kyrylchuk</name></author><author><name sortKey="Krolicki, Lesrek" sort="Krolicki, Lesrek" uniqKey="Krolicki L" first="Lesrek" last="Krolicki">Lesrek Krolicki</name></author><author><name sortKey="Friedman, Andrzej" sort="Friedman, Andrzej" uniqKey="Friedman A" first="Andrzej" last="Friedman">Andrzej Friedman</name></author><author><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name></author><author><name sortKey="J Ger, H Rolf" sort="J Ger, H Rolf" uniqKey="J Ger H" first="H Rolf" last="J Ger">H Rolf J Ger</name></author><author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" 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last="Kyrylchuk">Marianna Kyrylchuk</name></author><author><name sortKey="Krolicki, Lesrek" sort="Krolicki, Lesrek" uniqKey="Krolicki L" first="Lesrek" last="Krolicki">Lesrek Krolicki</name></author><author><name sortKey="Friedman, Andrzej" sort="Friedman, Andrzej" uniqKey="Friedman A" first="Andrzej" last="Friedman">Andrzej Friedman</name></author><author><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name></author><author><name sortKey="J Ger, H Rolf" sort="J Ger, H Rolf" uniqKey="J Ger H" first="H Rolf" last="J Ger">H Rolf J Ger</name></author><author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name></author><author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder 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Disorders</term></keywords><keywords scheme="MESH" type="chemical" qualifier="poisoning" xml:lang="en"><term>Propiophenones</term><term>Street Drugs</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Dystonic Disorders</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A neurological syndrome characterized by levodopa unresponsive bradykinesia, retropulsion with falls backwards, dysarthria, gait disturbance, dystonia, and emotional lability was identified in 13 male opiate addicts following the prolonged intravenous use of ephedrone (methcathinone), a central nervous stimulant prepared from pseudoephedrine, potassium permanganate, and vinegar. The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were carried out. Pubic hair was sampled for manganese. The clinical and radiological picture closely resembled previous reports of chronic manganese poisoning and increased mean manganese level in pubic hair observed for at least 1 year after cessation of ephedrone. Odor identification was intact. Cognitive assessment showed a mild executive dysfunction and a mild depression. DaTSCANs were all normal. The neurological syndrome bears some similarities to PSP but differs from Parkinson's disease. Delayed neurological progression despite discontinuation of ephedrone occurred in one-third of cases. Ephedrone poisoning should be considered as a possible cause of secondary Parkinsonism in young adults, particularly from Eastern Europe.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Fedoryshyn, Ljuda" sort="Fedoryshyn, Ljuda" uniqKey="Fedoryshyn L" first="Ljuda" last="Fedoryshyn">Ljuda Fedoryshyn</name><name sortKey="Friedman, Andrzej" sort="Friedman, Andrzej" uniqKey="Friedman A" first="Andrzej" last="Friedman">Andrzej Friedman</name><name sortKey="J Ger, H Rolf" sort="J Ger, H Rolf" uniqKey="J Ger H" first="H Rolf" last="J Ger">H Rolf J Ger</name><name sortKey="Komnatska, Irena" sort="Komnatska, Irena" uniqKey="Komnatska I" first="Irena" last="Komnatska">Irena Komnatska</name><name sortKey="Krolicki, Lesrek" sort="Krolicki, Lesrek" uniqKey="Krolicki L" first="Lesrek" last="Krolicki">Lesrek Krolicki</name><name sortKey="Kyrylchuk, Marianna" sort="Kyrylchuk, Marianna" uniqKey="Kyrylchuk M" first="Marianna" last="Kyrylchuk">Marianna Kyrylchuk</name><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name><name sortKey="Matviyenko, Yuri" sort="Matviyenko, Yuri" uniqKey="Matviyenko Y" first="Yuri" last="Matviyenko">Yuri Matviyenko</name><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name><name sortKey="Taylor, Andrew" sort="Taylor, Andrew" uniqKey="Taylor A" first="Andrew" last="Taylor">Andrew Taylor</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Selikhova, Marianna" sort="Selikhova, Marianna" uniqKey="Selikhova M" first="Marianna" last="Selikhova">Marianna Selikhova</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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