Subthalamic nucleus stimulation restores corticospinal facilitation in Parkinson's disease.
Identifieur interne : 002282 ( Ncbi/Checkpoint ); précédent : 002281; suivant : 002283Subthalamic nucleus stimulation restores corticospinal facilitation in Parkinson's disease.
Auteurs : Monika Pötter-Nerger [Allemagne] ; Tihomir V. Ilic ; Hartwiq R. Siebner ; Günther Deuschl ; Jens VolkmannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Analysis of Variance, Deep Brain Stimulation (methods), Female, H-Reflex (physiology), Humans, Male, Middle Aged, Muscle, Skeletal (physiopathology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Pyramidal Tracts (physiopathology), Statistics, Nonparametric, Subthalamic Nucleus (physiology), Time Factors, Transcranial Magnetic Stimulation.
- MESH :
- methods : Deep Brain Stimulation.
- pathology : Parkinson Disease.
- physiology : H-Reflex, Subthalamic Nucleus.
- physiopathology : Muscle, Skeletal, Parkinson Disease, Pyramidal Tracts.
- therapy : Parkinson Disease.
- Analysis of Variance, Female, Humans, Male, Middle Aged, Statistics, Nonparametric, Time Factors, Transcranial Magnetic Stimulation.
Abstract
We have previously shown that in patients with Parkinson's disease (PD), high-frequency stimulation (HFS) of the subthalamic nucleus (STN) modifies spinal excitability via subcortical reticulospinal routes. To investigate whether STN-HFS also modifies spinal excitability via transcortical routes in PD, 10 patients with PD (9 men, 1 woman; 58.3 +/- 8.3 years) were investigated in the medical OFF-state with or without STN-HFS. The H-reflex of the right soleus muscle was recorded during slight plantar flexion at 20% of maximum force. A conditioning transcranial stimulus was applied at 95% of active motor threshold to the contralateral primary motor leg area (M1) 0-5 ms after eliciting the H-reflex. The same paradigm was applied to 8 healthy individuals (5 men, 3 women; 50.8 +/- 3.0 years). Transcranial magnetic stimulation (TMS) facilitated the H-reflex amplitude in healthy controls. A facilitatory effect of the corticospinal input on the H-reflex was also found in patients with PD, but only with STN-HFS switched on. When STN-HFS was discontinued, the H-reflex was no longer facilitated by the TMS pulse. Accordingly, analysis of variance showed a main effect of stimulation (F = 11.15; P = 0.005), ISI (F = 6.1; P = 0.003), and an interaction between stimulation and group (PD vs. control) (F = 8.9; P = 0.01). STN-HFS restores the normal facilitatory drive of a transcranially evoked motor cortical response to the spinal motoneuron pool. In addition to subcortical routes, STN-DBS also alters spinal excitability via transcortical pathways.
DOI: 10.1002/mds.22284
PubMed: 18759343
Affiliations:
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Ilic</name></author><author><name sortKey="Siebner, Hartwiq R" sort="Siebner, Hartwiq R" uniqKey="Siebner H" first="Hartwiq R" last="Siebner">Hartwiq R. Siebner</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22284</idno><idno type="RBID">pubmed:18759343</idno><idno type="pmid">18759343</idno><idno type="wicri:Area/PubMed/Corpus">002081</idno><idno type="wicri:Area/PubMed/Curation">002081</idno><idno type="wicri:Area/PubMed/Checkpoint">002074</idno><idno type="wicri:Area/Ncbi/Merge">002282</idno><idno type="wicri:Area/Ncbi/Curation">002282</idno><idno type="wicri:Area/Ncbi/Checkpoint">002282</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic nucleus stimulation restores corticospinal facilitation in Parkinson's disease.</title><author><name sortKey="Potter Nerger, Monika" sort="Potter Nerger, Monika" uniqKey="Potter Nerger M" first="Monika" last="Pötter-Nerger">Monika Pötter-Nerger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Christian-Albrechts-University, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian-Albrechts-University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Ilic, Tihomir V" sort="Ilic, Tihomir V" uniqKey="Ilic T" first="Tihomir V" last="Ilic">Tihomir V. Ilic</name></author><author><name sortKey="Siebner, Hartwiq R" sort="Siebner, Hartwiq R" uniqKey="Siebner H" first="Hartwiq R" last="Siebner">Hartwiq R. Siebner</name></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>H-Reflex (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscle, Skeletal (physiopathology)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Pyramidal Tracts (physiopathology)</term><term>Statistics, Nonparametric</term><term>Subthalamic Nucleus (physiology)</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>H-Reflex</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle, Skeletal</term><term>Parkinson Disease</term><term>Pyramidal Tracts</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have previously shown that in patients with Parkinson's disease (PD), high-frequency stimulation (HFS) of the subthalamic nucleus (STN) modifies spinal excitability via subcortical reticulospinal routes. To investigate whether STN-HFS also modifies spinal excitability via transcortical routes in PD, 10 patients with PD (9 men, 1 woman; 58.3 +/- 8.3 years) were investigated in the medical OFF-state with or without STN-HFS. The H-reflex of the right soleus muscle was recorded during slight plantar flexion at 20% of maximum force. A conditioning transcranial stimulus was applied at 95% of active motor threshold to the contralateral primary motor leg area (M1) 0-5 ms after eliciting the H-reflex. The same paradigm was applied to 8 healthy individuals (5 men, 3 women; 50.8 +/- 3.0 years). Transcranial magnetic stimulation (TMS) facilitated the H-reflex amplitude in healthy controls. A facilitatory effect of the corticospinal input on the H-reflex was also found in patients with PD, but only with STN-HFS switched on. When STN-HFS was discontinued, the H-reflex was no longer facilitated by the TMS pulse. Accordingly, analysis of variance showed a main effect of stimulation (F = 11.15; P = 0.005), ISI (F = 6.1; P = 0.003), and an interaction between stimulation and group (PD vs. control) (F = 8.9; P = 0.01). STN-HFS restores the normal facilitatory drive of a transcranially evoked motor cortical response to the spinal motoneuron pool. In addition to subcortical routes, STN-DBS also alters spinal excitability via transcortical pathways.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li></settlement></list><tree><noCountry><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><name sortKey="Ilic, Tihomir V" sort="Ilic, Tihomir V" uniqKey="Ilic T" first="Tihomir V" last="Ilic">Tihomir V. Ilic</name><name sortKey="Siebner, Hartwiq R" sort="Siebner, Hartwiq R" uniqKey="Siebner H" first="Hartwiq R" last="Siebner">Hartwiq R. Siebner</name><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></noCountry><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Potter Nerger, Monika" sort="Potter Nerger, Monika" uniqKey="Potter Nerger M" first="Monika" last="Pötter-Nerger">Monika Pötter-Nerger</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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