Gender-related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson's disease patients.
Identifieur interne : 002200 ( Ncbi/Checkpoint ); précédent : 002199; suivant : 002201Gender-related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson's disease patients.
Auteurs : Evelien Huisman [Pays-Bas] ; Harry B M. Uylings ; Piet V. HooglandSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cell Count, Dopamine (biosynthesis), Dopamine (physiology), Female, Humans, Male, Middle Aged, Nerve Tissue Proteins (analysis), Neurons (enzymology), Neurons (pathology), Olfaction Disorders (etiology), Olfaction Disorders (pathology), Olfactory Bulb (chemistry), Olfactory Bulb (pathology), Parkinson Disease (complications), Parkinson Disease (pathology), Sex Characteristics, Tyrosine 3-Monooxygenase (analysis).
- MESH :
- chemical , analysis : Nerve Tissue Proteins, Tyrosine 3-Monooxygenase.
- chemical , biosynthesis : Dopamine.
- chemical , physiology : Dopamine.
- chemistry : Olfactory Bulb.
- complications : Parkinson Disease.
- enzymology : Neurons.
- etiology : Olfaction Disorders.
- pathology : Neurons, Olfaction Disorders, Olfactory Bulb, Parkinson Disease.
- Aged, Aged, 80 and over, Cell Count, Female, Humans, Male, Middle Aged, Sex Characteristics.
Abstract
Gender differences in dopaminergic related neurodegenerative diseases have hardly been studied until now. It is generally accepted that more men than women suffer from Parkinson's disease. One of the most prevalent symptoms in Parkinson's patients, hyposmia, does not show gender differences, while normally the sense of smell is better developed in females. Whether the change in dopamine in the olfactory bulb contributes equally to hyposmia in male and female Parkinson's patients is the subject of the present study. In a stereological study the total number of tyrosine hydroxylase immunoreactive neurons in the olfactory bulbs of male and female Parkinson's patients and age-matched controls has been estimated. The present stereological study shows that the number of tyrosine hydroxylase positive cells in control females is significantly lower than those in control males. The number of dopaminergic cells in the olfactory bulbs of both male and female Parkinson's patients equals that of healthy males of the same age group. We therefore conclude that the hyposmia in Parkinson's disease patients cannot simply be ascribed to dopamine in the olfactory bulb.
DOI: 10.1002/mds.22009
PubMed: 18581481
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gender-related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson's disease patients.</title><author><name sortKey="Huisman, Evelien" sort="Huisman, Evelien" uniqKey="Huisman E" first="Evelien" last="Huisman">Evelien Huisman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands. e.timmermans@vumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Uylings, Harry B M" sort="Uylings, Harry B M" uniqKey="Uylings H" first="Harry B M" last="Uylings">Harry B M. Uylings</name></author><author><name sortKey="Hoogland, Piet V" sort="Hoogland, Piet V" uniqKey="Hoogland P" first="Piet V" last="Hoogland">Piet V. Hoogland</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22009</idno><idno type="RBID">pubmed:18581481</idno><idno type="pmid">18581481</idno><idno type="wicri:Area/PubMed/Corpus">002163</idno><idno type="wicri:Area/PubMed/Curation">002163</idno><idno type="wicri:Area/PubMed/Checkpoint">002276</idno><idno type="wicri:Area/Ncbi/Merge">002200</idno><idno type="wicri:Area/Ncbi/Curation">002200</idno><idno type="wicri:Area/Ncbi/Checkpoint">002200</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gender-related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson's disease patients.</title><author><name sortKey="Huisman, Evelien" sort="Huisman, Evelien" uniqKey="Huisman E" first="Evelien" last="Huisman">Evelien Huisman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands. e.timmermans@vumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Uylings, Harry B M" sort="Uylings, Harry B M" uniqKey="Uylings H" first="Harry B M" last="Uylings">Harry B M. Uylings</name></author><author><name sortKey="Hoogland, Piet V" sort="Hoogland, Piet V" uniqKey="Hoogland P" first="Piet V" last="Hoogland">Piet V. Hoogland</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cell Count</term><term>Dopamine (biosynthesis)</term><term>Dopamine (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nerve Tissue Proteins (analysis)</term><term>Neurons (enzymology)</term><term>Neurons (pathology)</term><term>Olfaction Disorders (etiology)</term><term>Olfaction Disorders (pathology)</term><term>Olfactory Bulb (chemistry)</term><term>Olfactory Bulb (pathology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Sex Characteristics</term><term>Tyrosine 3-Monooxygenase (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Nerve Tissue Proteins</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Olfactory Bulb</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurons</term><term>Olfaction Disorders</term><term>Olfactory Bulb</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cell Count</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Sex Characteristics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gender differences in dopaminergic related neurodegenerative diseases have hardly been studied until now. It is generally accepted that more men than women suffer from Parkinson's disease. One of the most prevalent symptoms in Parkinson's patients, hyposmia, does not show gender differences, while normally the sense of smell is better developed in females. Whether the change in dopamine in the olfactory bulb contributes equally to hyposmia in male and female Parkinson's patients is the subject of the present study. In a stereological study the total number of tyrosine hydroxylase immunoreactive neurons in the olfactory bulbs of male and female Parkinson's patients and age-matched controls has been estimated. The present stereological study shows that the number of tyrosine hydroxylase positive cells in control females is significantly lower than those in control males. The number of dopaminergic cells in the olfactory bulbs of both male and female Parkinson's patients equals that of healthy males of the same age group. We therefore conclude that the hyposmia in Parkinson's disease patients cannot simply be ascribed to dopamine in the olfactory bulb.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement></list><tree><noCountry><name sortKey="Hoogland, Piet V" sort="Hoogland, Piet V" uniqKey="Hoogland P" first="Piet V" last="Hoogland">Piet V. Hoogland</name><name sortKey="Uylings, Harry B M" sort="Uylings, Harry B M" uniqKey="Uylings H" first="Harry B M" last="Uylings">Harry B M. Uylings</name></noCountry><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Huisman, Evelien" sort="Huisman, Evelien" uniqKey="Huisman E" first="Evelien" last="Huisman">Evelien Huisman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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