PET study of brain acetylcholinesterase in cerebellar degenerative disorders.
Identifieur interne : 002108 ( Ncbi/Checkpoint ); précédent : 002107; suivant : 002109PET study of brain acetylcholinesterase in cerebellar degenerative disorders.
Auteurs : Shigeki Hirano [Japon] ; Hitoshi Shinotoh ; Kimihito Arai ; Akiyo Aotsuka ; Fumihiko Yasuno ; Noriko Tanaka ; Tsuneyoshi Ota ; Koichi Sato ; Kiyoshi Fukushi ; Shuji Tanada ; Takamichi Hattori ; Toshiaki IrieSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Acetylcholinesterase (metabolism), Adult, Aged, Brain (radionuclide imaging), Carbon Radioisotopes (diagnostic use), Cerebellar Cortex (radionuclide imaging), Cerebral Cortex (radionuclide imaging), Female, Humans, Image Processing, Computer-Assisted, Machado-Joseph Disease (radionuclide imaging), Magnetic Resonance Imaging, Male, Middle Aged, Multiple System Atrophy (radionuclide imaging), Neurologic Examination, Piperidines (diagnostic use), Positron-Emission Tomography, Propionates (diagnostic use), Spinocerebellar Ataxias (radionuclide imaging), Spinocerebellar Degenerations (radionuclide imaging), Thalamus (radionuclide imaging).
- MESH :
- chemical , diagnostic use : Carbon Radioisotopes, Piperidines, Propionates.
- chemical , metabolism : Acetylcholinesterase.
- radionuclide imaging : Brain, Cerebellar Cortex, Cerebral Cortex, Machado-Joseph Disease, Multiple System Atrophy, Spinocerebellar Ataxias, Spinocerebellar Degenerations, Thalamus.
- Adult, Aged, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Positron-Emission Tomography.
Abstract
To elucidate characteristic changes of brain acetylcholinesterase (AChE) in cerebellar degenerative disorders. Eight patients with the cerebellar variant of multiple system atrophy (MSA-C), 7 patients with spinocerebellar ataxia type-3 (SCA-3), 3 patients with SCA-6, and 13 healthy age-matched volunteers participated in this study. Brain AChE activity was measured by [(11)C] N-methylpiperidin-4-yl propionate PET in all subjects. Brain AChE activities were significantly decreased in the thalamus (-27%) and the posterior lobe of cerebellar cortex (-36%) in patients with MSA-C and in the thalamus (-23%) in patients with SCA-3 compared with healthy controls (P < 0.01). Thalamic AChE activities of SCA-3 patients were negatively correlated with the unified Parkinson's disease rating scale motor subscore (P < 0.001). AChE activities were not significantly altered in the cerebral cortex in any disease group. Reduction of AChE activities in the thalamus and cerebellum in MSA and in the thalamus in SCA-3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders.
DOI: 10.1002/mds.22056
PubMed: 18412283
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002253
- to stream PubMed, to step Curation: 002253
- to stream PubMed, to step Checkpoint: 002170
- to stream Ncbi, to step Merge: 002108
- to stream Ncbi, to step Curation: 002108
Links to Exploration step
pubmed:18412283Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PET study of brain acetylcholinesterase in cerebellar degenerative disorders.</title><author><name sortKey="Hirano, Shigeki" sort="Hirano, Shigeki" uniqKey="Hirano S" first="Shigeki" last="Hirano">Shigeki Hirano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Chiba University Graduate School of Medicine, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Shinotoh, Hitoshi" sort="Shinotoh, Hitoshi" uniqKey="Shinotoh H" first="Hitoshi" last="Shinotoh">Hitoshi Shinotoh</name></author><author><name sortKey="Arai, Kimihito" sort="Arai, Kimihito" uniqKey="Arai K" first="Kimihito" last="Arai">Kimihito Arai</name></author><author><name sortKey="Aotsuka, Akiyo" sort="Aotsuka, Akiyo" uniqKey="Aotsuka A" first="Akiyo" last="Aotsuka">Akiyo Aotsuka</name></author><author><name sortKey="Yasuno, Fumihiko" sort="Yasuno, Fumihiko" uniqKey="Yasuno F" first="Fumihiko" last="Yasuno">Fumihiko Yasuno</name></author><author><name sortKey="Tanaka, Noriko" sort="Tanaka, Noriko" uniqKey="Tanaka N" first="Noriko" last="Tanaka">Noriko Tanaka</name></author><author><name sortKey="Ota, Tsuneyoshi" sort="Ota, Tsuneyoshi" uniqKey="Ota T" first="Tsuneyoshi" last="Ota">Tsuneyoshi Ota</name></author><author><name sortKey="Sato, Koichi" sort="Sato, Koichi" uniqKey="Sato K" first="Koichi" last="Sato">Koichi Sato</name></author><author><name sortKey="Fukushi, Kiyoshi" sort="Fukushi, Kiyoshi" uniqKey="Fukushi K" first="Kiyoshi" last="Fukushi">Kiyoshi Fukushi</name></author><author><name sortKey="Tanada, Shuji" sort="Tanada, Shuji" uniqKey="Tanada S" first="Shuji" last="Tanada">Shuji Tanada</name></author><author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name></author><author><name sortKey="Irie, Toshiaki" sort="Irie, Toshiaki" uniqKey="Irie T" first="Toshiaki" last="Irie">Toshiaki Irie</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22056</idno><idno type="RBID">pubmed:18412283</idno><idno type="pmid">18412283</idno><idno type="wicri:Area/PubMed/Corpus">002253</idno><idno type="wicri:Area/PubMed/Curation">002253</idno><idno type="wicri:Area/PubMed/Checkpoint">002170</idno><idno type="wicri:Area/Ncbi/Merge">002108</idno><idno type="wicri:Area/Ncbi/Curation">002108</idno><idno type="wicri:Area/Ncbi/Checkpoint">002108</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">PET study of brain acetylcholinesterase in cerebellar degenerative disorders.</title><author><name sortKey="Hirano, Shigeki" sort="Hirano, Shigeki" uniqKey="Hirano S" first="Shigeki" last="Hirano">Shigeki Hirano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Chiba University Graduate School of Medicine, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Shinotoh, Hitoshi" sort="Shinotoh, Hitoshi" uniqKey="Shinotoh H" first="Hitoshi" last="Shinotoh">Hitoshi Shinotoh</name></author><author><name sortKey="Arai, Kimihito" sort="Arai, Kimihito" uniqKey="Arai K" first="Kimihito" last="Arai">Kimihito Arai</name></author><author><name sortKey="Aotsuka, Akiyo" sort="Aotsuka, Akiyo" uniqKey="Aotsuka A" first="Akiyo" last="Aotsuka">Akiyo Aotsuka</name></author><author><name sortKey="Yasuno, Fumihiko" sort="Yasuno, Fumihiko" uniqKey="Yasuno F" first="Fumihiko" last="Yasuno">Fumihiko Yasuno</name></author><author><name sortKey="Tanaka, Noriko" sort="Tanaka, Noriko" uniqKey="Tanaka N" first="Noriko" last="Tanaka">Noriko Tanaka</name></author><author><name sortKey="Ota, Tsuneyoshi" sort="Ota, Tsuneyoshi" uniqKey="Ota T" first="Tsuneyoshi" last="Ota">Tsuneyoshi Ota</name></author><author><name sortKey="Sato, Koichi" sort="Sato, Koichi" uniqKey="Sato K" first="Koichi" last="Sato">Koichi Sato</name></author><author><name sortKey="Fukushi, Kiyoshi" sort="Fukushi, Kiyoshi" uniqKey="Fukushi K" first="Kiyoshi" last="Fukushi">Kiyoshi Fukushi</name></author><author><name sortKey="Tanada, Shuji" sort="Tanada, Shuji" uniqKey="Tanada S" first="Shuji" last="Tanada">Shuji Tanada</name></author><author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name></author><author><name sortKey="Irie, Toshiaki" sort="Irie, Toshiaki" uniqKey="Irie T" first="Toshiaki" last="Irie">Toshiaki Irie</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholinesterase (metabolism)</term><term>Adult</term><term>Aged</term><term>Brain (radionuclide imaging)</term><term>Carbon Radioisotopes (diagnostic use)</term><term>Cerebellar Cortex (radionuclide imaging)</term><term>Cerebral Cortex (radionuclide imaging)</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Machado-Joseph Disease (radionuclide imaging)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (radionuclide imaging)</term><term>Neurologic Examination</term><term>Piperidines (diagnostic use)</term><term>Positron-Emission Tomography</term><term>Propionates (diagnostic use)</term><term>Spinocerebellar Ataxias (radionuclide imaging)</term><term>Spinocerebellar Degenerations (radionuclide imaging)</term><term>Thalamus (radionuclide imaging)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Carbon Radioisotopes</term><term>Piperidines</term><term>Propionates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acetylcholinesterase</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Cerebellar Cortex</term><term>Cerebral Cortex</term><term>Machado-Joseph Disease</term><term>Multiple System Atrophy</term><term>Spinocerebellar Ataxias</term><term>Spinocerebellar Degenerations</term><term>Thalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Positron-Emission Tomography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To elucidate characteristic changes of brain acetylcholinesterase (AChE) in cerebellar degenerative disorders. Eight patients with the cerebellar variant of multiple system atrophy (MSA-C), 7 patients with spinocerebellar ataxia type-3 (SCA-3), 3 patients with SCA-6, and 13 healthy age-matched volunteers participated in this study. Brain AChE activity was measured by [(11)C] N-methylpiperidin-4-yl propionate PET in all subjects. Brain AChE activities were significantly decreased in the thalamus (-27%) and the posterior lobe of cerebellar cortex (-36%) in patients with MSA-C and in the thalamus (-23%) in patients with SCA-3 compared with healthy controls (P < 0.01). Thalamic AChE activities of SCA-3 patients were negatively correlated with the unified Parkinson's disease rating scale motor subscore (P < 0.001). AChE activities were not significantly altered in the cerebral cortex in any disease group. Reduction of AChE activities in the thalamus and cerebellum in MSA and in the thalamus in SCA-3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Aotsuka, Akiyo" sort="Aotsuka, Akiyo" uniqKey="Aotsuka A" first="Akiyo" last="Aotsuka">Akiyo Aotsuka</name><name sortKey="Arai, Kimihito" sort="Arai, Kimihito" uniqKey="Arai K" first="Kimihito" last="Arai">Kimihito Arai</name><name sortKey="Fukushi, Kiyoshi" sort="Fukushi, Kiyoshi" uniqKey="Fukushi K" first="Kiyoshi" last="Fukushi">Kiyoshi Fukushi</name><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name><name sortKey="Irie, Toshiaki" sort="Irie, Toshiaki" uniqKey="Irie T" first="Toshiaki" last="Irie">Toshiaki Irie</name><name sortKey="Ota, Tsuneyoshi" sort="Ota, Tsuneyoshi" uniqKey="Ota T" first="Tsuneyoshi" last="Ota">Tsuneyoshi Ota</name><name sortKey="Sato, Koichi" sort="Sato, Koichi" uniqKey="Sato K" first="Koichi" last="Sato">Koichi Sato</name><name sortKey="Shinotoh, Hitoshi" sort="Shinotoh, Hitoshi" uniqKey="Shinotoh H" first="Hitoshi" last="Shinotoh">Hitoshi Shinotoh</name><name sortKey="Tanada, Shuji" sort="Tanada, Shuji" uniqKey="Tanada S" first="Shuji" last="Tanada">Shuji Tanada</name><name sortKey="Tanaka, Noriko" sort="Tanaka, Noriko" uniqKey="Tanaka N" first="Noriko" last="Tanaka">Noriko Tanaka</name><name sortKey="Yasuno, Fumihiko" sort="Yasuno, Fumihiko" uniqKey="Yasuno F" first="Fumihiko" last="Yasuno">Fumihiko Yasuno</name></noCountry><country name="Japon"><noRegion><name sortKey="Hirano, Shigeki" sort="Hirano, Shigeki" uniqKey="Hirano S" first="Shigeki" last="Hirano">Shigeki Hirano</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002108 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 002108 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:18412283
|texte= PET study of brain acetylcholinesterase in cerebellar degenerative disorders.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:18412283" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |