Microsubthalamotomy: an immediate predictor of long-term subthalamic stimulation efficacy in Parkinson disease.
Identifieur interne : 002106 ( Ncbi/Checkpoint ); précédent : 002105; suivant : 002107Microsubthalamotomy: an immediate predictor of long-term subthalamic stimulation efficacy in Parkinson disease.
Auteurs : David Maltête [France] ; Stéphane Derrey ; Nathalie Chastan ; Bertrand Debono ; Emmanuel Gérardin ; Pierre Fréger ; Bruno Mihout ; Jean François Menard ; Didier HannequinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Deep Brain Stimulation (methods), Female, Humans, Male, Microsurgery (methods), Middle Aged, Neurosurgical Procedures (methods), Parkinson Disease (surgery), Parkinson Disease (therapy), Postoperative Care, Predictive Value of Tests, Subthalamic Nucleus (surgery), Time Factors, Treatment Outcome.
- MESH :
- methods : Deep Brain Stimulation, Microsurgery, Neurosurgical Procedures.
- surgery : Parkinson Disease, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Postoperative Care, Predictive Value of Tests, Time Factors, Treatment Outcome.
Abstract
A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.
DOI: 10.1002/mds.22054
PubMed: 18412281
Affiliations:
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Chastan</name></author><author><name sortKey="Debono, Bertrand" sort="Debono, Bertrand" uniqKey="Debono B" first="Bertrand" last="Debono">Bertrand Debono</name></author><author><name sortKey="Gerardin, Emmanuel" sort="Gerardin, Emmanuel" uniqKey="Gerardin E" first="Emmanuel" last="Gérardin">Emmanuel Gérardin</name></author><author><name sortKey="Freger, Pierre" sort="Freger, Pierre" uniqKey="Freger P" first="Pierre" last="Fréger">Pierre Fréger</name></author><author><name sortKey="Mihout, Bruno" sort="Mihout, Bruno" uniqKey="Mihout B" first="Bruno" last="Mihout">Bruno Mihout</name></author><author><name sortKey="Menard, Jean Francois" sort="Menard, Jean Francois" uniqKey="Menard J" first="Jean François" last="Menard">Jean François Menard</name></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date 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Neurology, Rouen University Hospital, Rouen</wicri:regionArea><placeName><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Derrey, Stephane" sort="Derrey, Stephane" uniqKey="Derrey S" first="Stéphane" last="Derrey">Stéphane Derrey</name></author><author><name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name></author><author><name sortKey="Debono, Bertrand" sort="Debono, Bertrand" uniqKey="Debono B" first="Bertrand" last="Debono">Bertrand Debono</name></author><author><name sortKey="Gerardin, Emmanuel" sort="Gerardin, Emmanuel" uniqKey="Gerardin E" first="Emmanuel" last="Gérardin">Emmanuel Gérardin</name></author><author><name sortKey="Freger, Pierre" sort="Freger, Pierre" uniqKey="Freger P" first="Pierre" last="Fréger">Pierre Fréger</name></author><author><name sortKey="Mihout, Bruno" sort="Mihout, Bruno" uniqKey="Mihout B" first="Bruno" last="Mihout">Bruno Mihout</name></author><author><name sortKey="Menard, Jean Francois" sort="Menard, Jean Francois" uniqKey="Menard J" first="Jean François" last="Menard">Jean François Menard</name></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Microsurgery (methods)</term><term>Middle Aged</term><term>Neurosurgical Procedures (methods)</term><term>Parkinson Disease (surgery)</term><term>Parkinson Disease (therapy)</term><term>Postoperative Care</term><term>Predictive Value of Tests</term><term>Subthalamic Nucleus (surgery)</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Microsurgery</term><term>Neurosurgical Procedures</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Postoperative Care</term><term>Predictive Value of Tests</term><term>Time Factors</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long-term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6-month postoperative UPDRS III motor score improvement in the off-drug/on-stimulation condition.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Rouen</li></settlement></list><tree><noCountry><name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name><name sortKey="Debono, Bertrand" sort="Debono, Bertrand" uniqKey="Debono B" first="Bertrand" last="Debono">Bertrand Debono</name><name sortKey="Derrey, Stephane" sort="Derrey, Stephane" uniqKey="Derrey S" first="Stéphane" last="Derrey">Stéphane Derrey</name><name sortKey="Freger, Pierre" sort="Freger, Pierre" uniqKey="Freger P" first="Pierre" last="Fréger">Pierre Fréger</name><name sortKey="Gerardin, Emmanuel" sort="Gerardin, Emmanuel" uniqKey="Gerardin E" first="Emmanuel" last="Gérardin">Emmanuel Gérardin</name><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><name sortKey="Menard, Jean Francois" sort="Menard, Jean Francois" uniqKey="Menard J" first="Jean François" last="Menard">Jean François Menard</name><name sortKey="Mihout, Bruno" sort="Mihout, Bruno" uniqKey="Mihout B" first="Bruno" last="Mihout">Bruno Mihout</name></noCountry><country name="France"><noRegion><name sortKey="Maltete, David" sort="Maltete, David" uniqKey="Maltete D" first="David" last="Maltête">David Maltête</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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