Effect of short and long term STN stimulation periods on parkinsonian signs.
Identifieur interne : 002064 ( Ncbi/Checkpoint ); précédent : 002063; suivant : 002065Effect of short and long term STN stimulation periods on parkinsonian signs.
Auteurs : Molly M. Sturman [États-Unis] ; David E. Vaillancourt ; Mark B. Shapiro ; Leo Verhagen Metman ; Roy A E. Bakay ; Daniel M. CorcosSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Ankle Joint (physiopathology), Deep Brain Stimulation (methods), Elbow Joint (physiopathology), Female, Functional Laterality, Humans, Hypokinesia (diagnosis), Hypokinesia (physiopathology), Male, Middle Aged, Muscle Rigidity (physiopathology), Muscle Rigidity (therapy), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Parkinson Disease (therapy), Subthalamic Nucleus (physiopathology).
- MESH :
- diagnosis : Hypokinesia.
- methods : Deep Brain Stimulation.
- physiopathology : Ankle Joint, Elbow Joint, Hypokinesia, Muscle Rigidity, Parkinson Disease, Subthalamic Nucleus.
- surgery : Parkinson Disease.
- therapy : Muscle Rigidity, Parkinson Disease.
- Aged, Female, Functional Laterality, Humans, Male, Middle Aged.
Abstract
Currently, no study of subthalamic nucleus (STN) stimulation has compared continuous stimulation with a period of short-term stimulation, which is frequently employed in the clinic and in research studies. Therefore, this study examined the effects of STN stimulation over 90 min (short) and greater than 3 months (long) on the cardinal signs of Parkinson's disease. The 90 min time period immediately followed a 12 hour withdrawal from both STN stimulation and medication. Ten PD patients who received STN stimulation were studied. Bradykinesia, rigidity, and tremor were evaluated using the UPDRS and motor control measures which included peak velocity (bradykinesia), work (rigidity), and amplitude (tremor). Results showed no difference between 90 min and greater than 3 months of STN stimulation for the UPDRS or motor control measures. This finding confirms that the treatment efficacy that is derived from a relatively short time course of stimulation generalizes to longer time periods of high frequency STN stimulation that patients experience in their daily lives. As such, it is reasonable to evaluate the effect of DBS after 90 min of stimulation in clinical trials and research studies.
DOI: 10.1002/mds.21979
PubMed: 18311827
Affiliations:
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Vaillancourt</name></author><author><name sortKey="Shapiro, Mark B" sort="Shapiro, Mark B" uniqKey="Shapiro M" first="Mark B" last="Shapiro">Mark B. Shapiro</name></author><author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A E" last="Bakay">Roy A E. Bakay</name></author><author><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M" last="Corcos">Daniel M. 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Sturman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA. msturm3@uic.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E" last="Vaillancourt">David E. Vaillancourt</name></author><author><name sortKey="Shapiro, Mark B" sort="Shapiro, Mark B" uniqKey="Shapiro M" first="Mark B" last="Shapiro">Mark B. Shapiro</name></author><author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A E" last="Bakay">Roy A E. Bakay</name></author><author><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M" last="Corcos">Daniel M. Corcos</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Ankle Joint (physiopathology)</term><term>Deep Brain Stimulation (methods)</term><term>Elbow Joint (physiopathology)</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Hypokinesia (diagnosis)</term><term>Hypokinesia (physiopathology)</term><term>Male</term><term>Middle Aged</term><term>Muscle Rigidity (physiopathology)</term><term>Muscle Rigidity (therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypokinesia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Ankle Joint</term><term>Elbow Joint</term><term>Hypokinesia</term><term>Muscle Rigidity</term><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Muscle Rigidity</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Currently, no study of subthalamic nucleus (STN) stimulation has compared continuous stimulation with a period of short-term stimulation, which is frequently employed in the clinic and in research studies. Therefore, this study examined the effects of STN stimulation over 90 min (short) and greater than 3 months (long) on the cardinal signs of Parkinson's disease. The 90 min time period immediately followed a 12 hour withdrawal from both STN stimulation and medication. Ten PD patients who received STN stimulation were studied. Bradykinesia, rigidity, and tremor were evaluated using the UPDRS and motor control measures which included peak velocity (bradykinesia), work (rigidity), and amplitude (tremor). Results showed no difference between 90 min and greater than 3 months of STN stimulation for the UPDRS or motor control measures. This finding confirms that the treatment efficacy that is derived from a relatively short time course of stimulation generalizes to longer time periods of high frequency STN stimulation that patients experience in their daily lives. As such, it is reasonable to evaluate the effect of DBS after 90 min of stimulation in clinical trials and research studies.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><noCountry><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A E" last="Bakay">Roy A E. Bakay</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M" last="Corcos">Daniel M. Corcos</name><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><name sortKey="Shapiro, Mark B" sort="Shapiro, Mark B" uniqKey="Shapiro M" first="Mark B" last="Shapiro">Mark B. Shapiro</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E" last="Vaillancourt">David E. Vaillancourt</name></noCountry><country name="États-Unis"><region name="Illinois"><name sortKey="Sturman, Molly M" sort="Sturman, Molly M" uniqKey="Sturman M" first="Molly M" last="Sturman">Molly M. Sturman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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