Future directions in the treatment of Parkinson's disease.
Identifieur interne : 002018 ( Ncbi/Checkpoint ); précédent : 002017; suivant : 002019Future directions in the treatment of Parkinson's disease.
Auteurs : Anthony H V. Schapira [Royaume-Uni]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Cholinergic Antagonists (therapeutic use), Coenzymes (therapeutic use), Dopamine Agonists (therapeutic use), Drug Therapy (trends), Forecasting, Humans, Intercellular Signaling Peptides and Proteins (therapeutic use), Monoamine Oxidase Inhibitors (therapeutic use), Parkinson Disease (drug therapy), Ubiquinone (analogs & derivatives), Ubiquinone (therapeutic use).
- MESH :
- chemical , analogs & derivatives : Ubiquinone.
- chemical , therapeutic use : Cholinergic Antagonists, Coenzymes, Dopamine Agonists, Intercellular Signaling Peptides and Proteins, Monoamine Oxidase Inhibitors, Ubiquinone.
- drug therapy : Parkinson Disease.
- trends : Drug Therapy.
- Forecasting, Humans.
Abstract
The development of treatment for the symptoms of Parkinson's disease (PD) has been one of the most notable successes of neurology. Dopaminergic therapies in the form of levodopa, dopamine agonists, or monoamine oxidase B inhibitors significantly improve the characteristic motor symptoms of bradykinesia and rigidity, with a beneficial effect upon tremor in a proportion of patients. Novel delivery of dopaminergic drugs whether in the form of once a day sustained release preparations or transdermal applications ensures that they remain at the forefront of PD treatment. The development of drugs to slow the progression of PD has attracted considerable attention and there appears to be some measure of success although additional studies need to be performed. A range of nondopaminergic drugs including alpha 2-adrenergic antagonists, serotoninergics, and adenosine A2a antagonists are in late-stage development for PD and offer benefit for motor symptoms and motor complications.
DOI: 10.1002/mds.21679
PubMed: 18175401
Affiliations:
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pubmed:18175401Le document en format XML
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Schapira</name><affiliation wicri:level="3"><nlm:affiliation>University Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London, UK. a.schapira@medsch.ucl.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cholinergic Antagonists (therapeutic use)</term><term>Coenzymes (therapeutic use)</term><term>Dopamine Agonists (therapeutic use)</term><term>Drug Therapy (trends)</term><term>Forecasting</term><term>Humans</term><term>Intercellular Signaling Peptides and Proteins (therapeutic use)</term><term>Monoamine Oxidase Inhibitors (therapeutic use)</term><term>Parkinson Disease (drug therapy)</term><term>Ubiquinone (analogs & derivatives)</term><term>Ubiquinone (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ubiquinone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cholinergic Antagonists</term><term>Coenzymes</term><term>Dopamine Agonists</term><term>Intercellular Signaling Peptides and Proteins</term><term>Monoamine Oxidase Inhibitors</term><term>Ubiquinone</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Drug Therapy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Forecasting</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The development of treatment for the symptoms of Parkinson's disease (PD) has been one of the most notable successes of neurology. Dopaminergic therapies in the form of levodopa, dopamine agonists, or monoamine oxidase B inhibitors significantly improve the characteristic motor symptoms of bradykinesia and rigidity, with a beneficial effect upon tremor in a proportion of patients. Novel delivery of dopaminergic drugs whether in the form of once a day sustained release preparations or transdermal applications ensures that they remain at the forefront of PD treatment. The development of drugs to slow the progression of PD has attracted considerable attention and there appears to be some measure of success although additional studies need to be performed. A range of nondopaminergic drugs including alpha 2-adrenergic antagonists, serotoninergics, and adenosine A2a antagonists are in late-stage development for PD and offer benefit for motor symptoms and motor complications.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H V" last="Schapira">Anthony H V. Schapira</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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