The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument.
Identifieur interne : 001E46 ( Ncbi/Checkpoint ); précédent : 001E45; suivant : 001E47The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument.
Auteurs : Karin Stiasny-Kolster [Allemagne] ; Geert Mayer ; Sylvia Sch Fer ; Jens Carsten Möller ; Monika Heinzel-Gutenbrunner ; Wolfgang H. OertelSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- diagnosis : REM Sleep Behavior Disorder.
- Adult, Aged, Aged, 80 and over, Female, Humans, Language, Male, Middle Aged, Polysomnography, Questionnaires, ROC Curve, Treatment Outcome.
Abstract
Many patients with assumed idiopathic REM sleep behavior disorder (RBD) may actually represent an early clinical manifestation of an evolving neurodegenerative disorder, such as the alpha-synucleinopathies, Parkinson's disease or multiple system atrophy. Early detection of these patients is clinically relevant for long-term prospective as well as future neuroprotective studies. For this purpose, we validated a 10-item patient self-rating questionnaire (maximum total score 13 points) covering the clinical features of RBD. The RBD screening questionnaire (RBDSQ) was applied to 54 patients with polysomnographically confirmed RBD (29 men; mean age 53.7 +/- 15.8 years), 160 control subjects (81 men; mean age 50.8 +/- 15.5 years) in whom RBD was excluded by history and polysomnography (PSG, control group 1) and 133 unselected healthy subjects (58 men; mean age 46.9 +/- 12.3 years; no PSG, control group 2). In most subjects (n = 153) of control group 1, other sleep-wake disturbances were present. The mean RBDSQ score in the RBD group was 9.5 +/- 2.8 points compared with 4.6 +/- 3.0 points in control group 1 (P < 0.0001). Considering an RBDSQ score of five points as a positive test result, we found a sensitivity of 0.96 and a specificity of 0.56. The RBDSQ poorly discriminated patients with the most challenging differential diagnoses such as sleepwalking or epilepsy. In control group 2, the mean RBDSQ score (2.02 +/- 1.78) was significantly lower than in the RBD group (P < 0.0005), revealing a specificity of 0.92. Due to its high sensitivity, the RBDSQ appears to be particularly useful as a screening tool.
DOI: 10.1002/mds.21740
PubMed: 17894337
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument.</title><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Center of Nervous Diseases, Philipps-University, Marburg, Germany. stiasny@med.uni-marburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps-University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Mayer, Geert" sort="Mayer, Geert" uniqKey="Mayer G" first="Geert" last="Mayer">Geert Mayer</name></author><author><name sortKey="Sch Fer, Sylvia" sort="Sch Fer, Sylvia" uniqKey="Sch Fer S" first="Sylvia" last="Sch Fer">Sylvia Sch Fer</name></author><author><name sortKey="Moller, Jens Carsten" sort="Moller, Jens Carsten" uniqKey="Moller J" first="Jens Carsten" last="Möller">Jens Carsten Möller</name></author><author><name sortKey="Heinzel Gutenbrunner, Monika" sort="Heinzel Gutenbrunner, Monika" uniqKey="Heinzel Gutenbrunner M" first="Monika" last="Heinzel-Gutenbrunner">Monika Heinzel-Gutenbrunner</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21740</idno><idno type="RBID">pubmed:17894337</idno><idno type="pmid">17894337</idno><idno type="wicri:Area/PubMed/Corpus">002513</idno><idno type="wicri:Area/PubMed/Curation">002513</idno><idno type="wicri:Area/PubMed/Checkpoint">002521</idno><idno type="wicri:Area/Ncbi/Merge">001E46</idno><idno type="wicri:Area/Ncbi/Curation">001E46</idno><idno type="wicri:Area/Ncbi/Checkpoint">001E46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument.</title><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Center of Nervous Diseases, Philipps-University, Marburg, Germany. stiasny@med.uni-marburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps-University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Mayer, Geert" sort="Mayer, Geert" uniqKey="Mayer G" first="Geert" last="Mayer">Geert Mayer</name></author><author><name sortKey="Sch Fer, Sylvia" sort="Sch Fer, Sylvia" uniqKey="Sch Fer S" first="Sylvia" last="Sch Fer">Sylvia Sch Fer</name></author><author><name sortKey="Moller, Jens Carsten" sort="Moller, Jens Carsten" uniqKey="Moller J" first="Jens Carsten" last="Möller">Jens Carsten Möller</name></author><author><name sortKey="Heinzel Gutenbrunner, Monika" sort="Heinzel Gutenbrunner, Monika" uniqKey="Heinzel Gutenbrunner M" first="Monika" last="Heinzel-Gutenbrunner">Monika Heinzel-Gutenbrunner</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Language</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term><term>Questionnaires</term><term>REM Sleep Behavior Disorder (diagnosis)</term><term>ROC Curve</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Language</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term><term>Questionnaires</term><term>ROC Curve</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many patients with assumed idiopathic REM sleep behavior disorder (RBD) may actually represent an early clinical manifestation of an evolving neurodegenerative disorder, such as the alpha-synucleinopathies, Parkinson's disease or multiple system atrophy. Early detection of these patients is clinically relevant for long-term prospective as well as future neuroprotective studies. For this purpose, we validated a 10-item patient self-rating questionnaire (maximum total score 13 points) covering the clinical features of RBD. The RBD screening questionnaire (RBDSQ) was applied to 54 patients with polysomnographically confirmed RBD (29 men; mean age 53.7 +/- 15.8 years), 160 control subjects (81 men; mean age 50.8 +/- 15.5 years) in whom RBD was excluded by history and polysomnography (PSG, control group 1) and 133 unselected healthy subjects (58 men; mean age 46.9 +/- 12.3 years; no PSG, control group 2). In most subjects (n = 153) of control group 1, other sleep-wake disturbances were present. The mean RBDSQ score in the RBD group was 9.5 +/- 2.8 points compared with 4.6 +/- 3.0 points in control group 1 (P < 0.0001). Considering an RBDSQ score of five points as a positive test result, we found a sensitivity of 0.96 and a specificity of 0.56. The RBDSQ poorly discriminated patients with the most challenging differential diagnoses such as sleepwalking or epilepsy. In control group 2, the mean RBDSQ score (2.02 +/- 1.78) was significantly lower than in the RBD group (P < 0.0005), revealing a specificity of 0.92. Due to its high sensitivity, the RBDSQ appears to be particularly useful as a screening tool.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><noCountry><name sortKey="Heinzel Gutenbrunner, Monika" sort="Heinzel Gutenbrunner, Monika" uniqKey="Heinzel Gutenbrunner M" first="Monika" last="Heinzel-Gutenbrunner">Monika Heinzel-Gutenbrunner</name><name sortKey="Mayer, Geert" sort="Mayer, Geert" uniqKey="Mayer G" first="Geert" last="Mayer">Geert Mayer</name><name sortKey="Moller, Jens Carsten" sort="Moller, Jens Carsten" uniqKey="Moller J" first="Jens Carsten" last="Möller">Jens Carsten Möller</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name><name sortKey="Sch Fer, Sylvia" sort="Sch Fer, Sylvia" uniqKey="Sch Fer S" first="Sylvia" last="Sch Fer">Sylvia Sch Fer</name></noCountry><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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