Restless legs syndrome in Parkinson's disease.
Identifieur interne : 001D15 ( Ncbi/Checkpoint ); précédent : 001D14; suivant : 001D16Restless legs syndrome in Parkinson's disease.
Auteurs : Juan C. G Mez-Esteban [Espagne] ; Juan J. Zarranz ; Beatriz Tijero ; Fernando Velasco ; Joseba Barcena ; Idoia Rouco ; Elena Lezcano ; María C. Lachen ; Amaia Jauregui ; Amaia UgarteSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Comorbidity, Cross-Sectional Studies, Disability Evaluation, Disorders of Excessive Somnolence (diagnosis), Disorders of Excessive Somnolence (epidemiology), Drug Therapy, Combination, Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Neurologic Examination, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Quality of Life, Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (drug therapy), Restless Legs Syndrome (epidemiology), Sick Role.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- diagnosis : Disorders of Excessive Somnolence, Parkinson Disease, Restless Legs Syndrome.
- drug therapy : Parkinson Disease, Restless Legs Syndrome.
- epidemiology : Disorders of Excessive Somnolence, Parkinson Disease, Restless Legs Syndrome.
- Aged, Comorbidity, Cross-Sectional Studies, Disability Evaluation, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Neurologic Examination, Quality of Life, Sick Role.
Abstract
The present study explores the frequency of RLS in PD and focuses on the clinical differences between patients with and without restless legs syndrome (RLS). A cross-sectional study was designed, comprising 114 patients diagnosed with PD. Those patients positive for RLS were assessed for intensity of the syndrome (IRLS). We compared the clinical characteristics of the patients with and without RLS, using specific scales: Unified Parkinson's Disease Rating Scale (UPDRS I-IV), quality of life (Parkinson's Disease Questionnaire, PDQ 39), sleep symptoms (Parkinson's Disease Sleep Scale, PDSS), and diurnal hypersomnia (Epworth Sleepiness Scale). Twenty-five patients (21.9%) out of a total of 114 subjects diagnosed with PD met the RLS diagnostic criteria. RLS was more frequent in women (68%). The patients with RLS showed poorer scores on the PDSS (PD-RLS+: 102.4 +/- 15.1 vs PD-RLS-: 113.2 +/- 16.4) (P = 0.005) and in the bodily discomfort dimension of the PDQ-39 (PD-RLS+ 6.1 +/- 3.4 vs PD-RLS- 3.8 +/- 2.6) (P = 0.002). Analysis of the subscales of the PDSS showed significant differences (P < 0.001) between both groups of patients in items 4 and 10, and to a lesser degree in items 5 (P = 0.01) and 11 (P = 0.02) There was no increased incidence of diurnal hypersomnia in the group of patients with RLS. There were no differences in the rest of the variables. RLS is frequent in patients with PD, though this condition doesn't apparently affect quality of life or lead to an increased presence of diurnal hypersomnia. It would be advisable to validate the diagnostic criteria of RLS in this specific group of patients.
DOI: 10.1002/mds.21624
PubMed: 17579369
Affiliations:
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Zarranz</name></author><author><name sortKey="Tijero, Beatriz" sort="Tijero, Beatriz" uniqKey="Tijero B" first="Beatriz" last="Tijero">Beatriz Tijero</name></author><author><name sortKey="Velasco, Fernando" sort="Velasco, Fernando" uniqKey="Velasco F" first="Fernando" last="Velasco">Fernando Velasco</name></author><author><name sortKey="Barcena, Joseba" sort="Barcena, Joseba" uniqKey="Barcena J" first="Joseba" last="Barcena">Joseba Barcena</name></author><author><name sortKey="Rouco, Idoia" sort="Rouco, Idoia" uniqKey="Rouco I" first="Idoia" last="Rouco">Idoia Rouco</name></author><author><name sortKey="Lezcano, Elena" sort="Lezcano, Elena" uniqKey="Lezcano E" first="Elena" last="Lezcano">Elena Lezcano</name></author><author><name sortKey="Lachen, Maria C" sort="Lachen, Maria C" uniqKey="Lachen M" first="María C" last="Lachen">María C. Lachen</name></author><author><name sortKey="Jauregui, Amaia" sort="Jauregui, Amaia" uniqKey="Jauregui A" first="Amaia" last="Jauregui">Amaia Jauregui</name></author><author><name sortKey="Ugarte, Amaia" sort="Ugarte, Amaia" uniqKey="Ugarte A" first="Amaia" last="Ugarte">Amaia Ugarte</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21624</idno><idno type="RBID">pubmed:17579369</idno><idno type="pmid">17579369</idno><idno type="wicri:Area/PubMed/Corpus">002624</idno><idno type="wicri:Area/PubMed/Curation">002624</idno><idno type="wicri:Area/PubMed/Checkpoint">002586</idno><idno type="wicri:Area/Ncbi/Merge">001D15</idno><idno type="wicri:Area/Ncbi/Curation">001D15</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Restless legs syndrome in Parkinson's disease.</title><author><name sortKey="G Mez Esteban, Juan C" sort="G Mez Esteban, Juan C" uniqKey="G Mez Esteban J" first="Juan C" last="G Mez-Esteban">Juan C. G Mez-Esteban</name><affiliation wicri:level="1"><nlm:affiliation>Neurology Service, Movement Disorders Unit, Hospital Cruces, Baracaldo, Vizcaya. jgomeze@meditex.es</nlm:affiliation><country wicri:rule="url">Espagne</country></affiliation></author><author><name sortKey="Zarranz, Juan J" sort="Zarranz, Juan J" uniqKey="Zarranz J" first="Juan J" last="Zarranz">Juan J. Zarranz</name></author><author><name sortKey="Tijero, Beatriz" sort="Tijero, Beatriz" uniqKey="Tijero B" first="Beatriz" last="Tijero">Beatriz Tijero</name></author><author><name sortKey="Velasco, Fernando" sort="Velasco, Fernando" uniqKey="Velasco F" first="Fernando" last="Velasco">Fernando Velasco</name></author><author><name sortKey="Barcena, Joseba" sort="Barcena, Joseba" uniqKey="Barcena J" first="Joseba" last="Barcena">Joseba Barcena</name></author><author><name sortKey="Rouco, Idoia" sort="Rouco, Idoia" uniqKey="Rouco I" first="Idoia" last="Rouco">Idoia Rouco</name></author><author><name sortKey="Lezcano, Elena" sort="Lezcano, Elena" uniqKey="Lezcano E" first="Elena" last="Lezcano">Elena Lezcano</name></author><author><name sortKey="Lachen, Maria C" sort="Lachen, Maria C" uniqKey="Lachen M" first="María C" last="Lachen">María C. Lachen</name></author><author><name sortKey="Jauregui, Amaia" sort="Jauregui, Amaia" uniqKey="Jauregui A" first="Amaia" last="Jauregui">Amaia Jauregui</name></author><author><name sortKey="Ugarte, Amaia" sort="Ugarte, Amaia" uniqKey="Ugarte A" first="Amaia" last="Ugarte">Amaia Ugarte</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Disability Evaluation</term><term>Disorders of Excessive Somnolence (diagnosis)</term><term>Disorders of Excessive Somnolence (epidemiology)</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Quality of Life</term><term>Restless Legs Syndrome (diagnosis)</term><term>Restless Legs Syndrome (drug therapy)</term><term>Restless Legs Syndrome (epidemiology)</term><term>Sick Role</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Disability Evaluation</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Quality of Life</term><term>Sick Role</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study explores the frequency of RLS in PD and focuses on the clinical differences between patients with and without restless legs syndrome (RLS). A cross-sectional study was designed, comprising 114 patients diagnosed with PD. Those patients positive for RLS were assessed for intensity of the syndrome (IRLS). We compared the clinical characteristics of the patients with and without RLS, using specific scales: Unified Parkinson's Disease Rating Scale (UPDRS I-IV), quality of life (Parkinson's Disease Questionnaire, PDQ 39), sleep symptoms (Parkinson's Disease Sleep Scale, PDSS), and diurnal hypersomnia (Epworth Sleepiness Scale). Twenty-five patients (21.9%) out of a total of 114 subjects diagnosed with PD met the RLS diagnostic criteria. RLS was more frequent in women (68%). The patients with RLS showed poorer scores on the PDSS (PD-RLS+: 102.4 +/- 15.1 vs PD-RLS-: 113.2 +/- 16.4) (P = 0.005) and in the bodily discomfort dimension of the PDQ-39 (PD-RLS+ 6.1 +/- 3.4 vs PD-RLS- 3.8 +/- 2.6) (P = 0.002). Analysis of the subscales of the PDSS showed significant differences (P < 0.001) between both groups of patients in items 4 and 10, and to a lesser degree in items 5 (P = 0.01) and 11 (P = 0.02) There was no increased incidence of diurnal hypersomnia in the group of patients with RLS. There were no differences in the rest of the variables. RLS is frequent in patients with PD, though this condition doesn't apparently affect quality of life or lead to an increased presence of diurnal hypersomnia. It would be advisable to validate the diagnostic criteria of RLS in this specific group of patients.</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Barcena, Joseba" sort="Barcena, Joseba" uniqKey="Barcena J" first="Joseba" last="Barcena">Joseba Barcena</name><name sortKey="Jauregui, Amaia" sort="Jauregui, Amaia" uniqKey="Jauregui A" first="Amaia" last="Jauregui">Amaia Jauregui</name><name sortKey="Lachen, Maria C" sort="Lachen, Maria C" uniqKey="Lachen M" first="María C" last="Lachen">María C. Lachen</name><name sortKey="Lezcano, Elena" sort="Lezcano, Elena" uniqKey="Lezcano E" first="Elena" last="Lezcano">Elena Lezcano</name><name sortKey="Rouco, Idoia" sort="Rouco, Idoia" uniqKey="Rouco I" first="Idoia" last="Rouco">Idoia Rouco</name><name sortKey="Tijero, Beatriz" sort="Tijero, Beatriz" uniqKey="Tijero B" first="Beatriz" last="Tijero">Beatriz Tijero</name><name sortKey="Ugarte, Amaia" sort="Ugarte, Amaia" uniqKey="Ugarte A" first="Amaia" last="Ugarte">Amaia Ugarte</name><name sortKey="Velasco, Fernando" sort="Velasco, Fernando" uniqKey="Velasco F" first="Fernando" last="Velasco">Fernando Velasco</name><name sortKey="Zarranz, Juan J" sort="Zarranz, Juan J" uniqKey="Zarranz J" first="Juan J" last="Zarranz">Juan J. Zarranz</name></noCountry><country name="Espagne"><noRegion><name sortKey="G Mez Esteban, Juan C" sort="G Mez Esteban, Juan C" uniqKey="G Mez Esteban J" first="Juan C" last="G Mez-Esteban">Juan C. 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