Mild Parkinsonian signs: An overview of an emerging concept.
Identifieur interne : 001C61 ( Ncbi/Checkpoint ); précédent : 001C60; suivant : 001C62Mild Parkinsonian signs: An overview of an emerging concept.
Auteurs : Elan D. Louis [États-Unis] ; David A. BennettSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Age Factors, Cerebrovascular Disorders (epidemiology), Cerebrovascular Disorders (physiopathology), Cognition Disorders (physiopathology), Humans, Neurologic Examination, Neuropsychological Tests, Parkinsonian Disorders (epidemiology), Parkinsonian Disorders (physiopathology), Prevalence, Risk Factors.
- MESH :
- epidemiology : Cerebrovascular Disorders, Parkinsonian Disorders.
- physiopathology : Cerebrovascular Disorders, Cognition Disorders, Parkinsonian Disorders.
- Age Factors, Humans, Neurologic Examination, Neuropsychological Tests, Prevalence, Risk Factors.
Abstract
Mild Parkinsonian signs (MPS) include gait and balance changes, rigidity, bradykinesia, and tremor. MPS can occur commonly during the clinical examination of older people who do not have known neurological disease, with prevalence estimates for MPS as a whole ranging from 15% to 95%. MPS are generally progressive and they are coupled with functional difficulties, impaired gait and balance, and increased risks of mild cognitive impairment, dementia, and mortality. The mechanistic basis for these signs is unclear, but is likely to be multifactorial, with possible factors including an age-associated decline in dopaminergic nigrostriatal activity, the early development of neurodegenerative (Lewy body or Alzheimer's type) pathologies in the basal ganglia, or the accumulation of vascular pathology in the brain. It would be valuable to identify those individuals with MPS who are at increased risk for the development of future Alzheimer's disease, full-blown Parkinson's disease, or strokes, and to develop therapeutic strategies to intervene to lessen the likelihood of MPS-related morbidity and mortality.
DOI: 10.1002/mds.21433
PubMed: 17534951
Affiliations:
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EDL2@columbia.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Cerebrovascular Disorders (epidemiology)</term><term>Cerebrovascular Disorders (physiopathology)</term><term>Cognition Disorders (physiopathology)</term><term>Humans</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Parkinsonian Disorders (epidemiology)</term><term>Parkinsonian Disorders (physiopathology)</term><term>Prevalence</term><term>Risk Factors</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cerebrovascular Disorders</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebrovascular Disorders</term><term>Cognition Disorders</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Humans</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Prevalence</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mild Parkinsonian signs (MPS) include gait and balance changes, rigidity, bradykinesia, and tremor. MPS can occur commonly during the clinical examination of older people who do not have known neurological disease, with prevalence estimates for MPS as a whole ranging from 15% to 95%. MPS are generally progressive and they are coupled with functional difficulties, impaired gait and balance, and increased risks of mild cognitive impairment, dementia, and mortality. The mechanistic basis for these signs is unclear, but is likely to be multifactorial, with possible factors including an age-associated decline in dopaminergic nigrostriatal activity, the early development of neurodegenerative (Lewy body or Alzheimer's type) pathologies in the basal ganglia, or the accumulation of vascular pathology in the brain. It would be valuable to identify those individuals with MPS who are at increased risk for the development of future Alzheimer's disease, full-blown Parkinson's disease, or strokes, and to develop therapeutic strategies to intervene to lessen the likelihood of MPS-related morbidity and mortality.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><noCountry><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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