Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient.
Identifieur interne : 001C59 ( Ncbi/Checkpoint ); précédent : 001C58; suivant : 001C60Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient.
Auteurs : Katie Kompoliti [États-Unis] ; Yaping Chu ; Kathleen M. Shannon ; Jeffrey H. KordowerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adrenal Medulla (cytology), Adrenal Medulla (transplantation), Autopsy (methods), Brain (pathology), Brain (surgery), Cell Survival (physiology), Chromogranin A (metabolism), Female, Humans, Longitudinal Studies, Middle Aged, Nerve Tissue Proteins (metabolism), Parkinson Disease (pathology), Parkinson Disease (surgery), Time Factors, Transplantation, Autologous (methods), Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : Chromogranin A, Nerve Tissue Proteins, Tyrosine 3-Monooxygenase.
- cytology : Adrenal Medulla.
- methods : Autopsy, Transplantation, Autologous.
- pathology : Brain, Parkinson Disease.
- physiology : Cell Survival.
- surgery : Brain, Parkinson Disease.
- transplantation : Adrenal Medulla.
- Female, Humans, Longitudinal Studies, Middle Aged, Time Factors.
Abstract
To date, there is no clinicopathological correlation of adrenal medullary transplant cases in patients with survival beyond a few years. Postmortem examination of a brain from a patient with Parkinson's disease (PD), 16 years after autologous adrenal medullary transplant, was performed using tyrosine hydroxylase (TH) and chromogranin A. The patient experienced a four-year initial improvement in motor function followed by resumption of the progressive nature of her disease that continued until her death. She expired 16 years following grafting. At autopsy, TH stain of the brain revealed severe loss of TH-immunoreactivity in the substantia nigra and Lewy bodies, confirming the diagnosis of PD. The transplant site was identified by the presence of scarring and there was complete absence of any TH staining cells at the site of the transplant. There were few surviving cells staining with chromogranin A. The absence of TH-staining cells in the transplant 16 years after surgery provides further evidence that adrenal medullary transplants do not survive in the long term.
DOI: 10.1002/mds.21528
PubMed: 17534949
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient.</title><author><name sortKey="Kompoliti, Katie" sort="Kompoliti, Katie" uniqKey="Kompoliti K" first="Katie" last="Kompoliti">Katie Kompoliti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. Katie_A_Kompoliti@rush.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea><wicri:noRegion>Illinois 60612</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name></author><author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name></author><author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21528</idno><idno type="RBID">pubmed:17534949</idno><idno type="pmid">17534949</idno><idno type="wicri:Area/PubMed/Corpus">002680</idno><idno type="wicri:Area/PubMed/Curation">002680</idno><idno type="wicri:Area/PubMed/Checkpoint">002694</idno><idno type="wicri:Area/Ncbi/Merge">001C59</idno><idno type="wicri:Area/Ncbi/Curation">001C59</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C59</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient.</title><author><name sortKey="Kompoliti, Katie" sort="Kompoliti, Katie" uniqKey="Kompoliti K" first="Katie" last="Kompoliti">Katie Kompoliti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. Katie_A_Kompoliti@rush.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea><wicri:noRegion>Illinois 60612</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name></author><author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name></author><author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Medulla (cytology)</term><term>Adrenal Medulla (transplantation)</term><term>Autopsy (methods)</term><term>Brain (pathology)</term><term>Brain (surgery)</term><term>Cell Survival (physiology)</term><term>Chromogranin A (metabolism)</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Middle Aged</term><term>Nerve Tissue Proteins (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (surgery)</term><term>Time Factors</term><term>Transplantation, Autologous (methods)</term><term>Tyrosine 3-Monooxygenase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chromogranin A</term><term>Nerve Tissue Proteins</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Adrenal Medulla</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Autopsy</term><term>Transplantation, Autologous</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Survival</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Adrenal Medulla</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Middle Aged</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To date, there is no clinicopathological correlation of adrenal medullary transplant cases in patients with survival beyond a few years. Postmortem examination of a brain from a patient with Parkinson's disease (PD), 16 years after autologous adrenal medullary transplant, was performed using tyrosine hydroxylase (TH) and chromogranin A. The patient experienced a four-year initial improvement in motor function followed by resumption of the progressive nature of her disease that continued until her death. She expired 16 years following grafting. At autopsy, TH stain of the brain revealed severe loss of TH-immunoreactivity in the substantia nigra and Lewy bodies, confirming the diagnosis of PD. The transplant site was identified by the presence of scarring and there was complete absence of any TH staining cells at the site of the transplant. There were few surviving cells staining with chromogranin A. The absence of TH-staining cells in the transplant 16 years after surgery provides further evidence that adrenal medullary transplants do not survive in the long term.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Kompoliti, Katie" sort="Kompoliti, Katie" uniqKey="Kompoliti K" first="Katie" last="Kompoliti">Katie Kompoliti</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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