Impaired cardiovascular autonomic function in Parkinson's disease with visual hallucinations.
Identifieur interne : 001C45 ( Ncbi/Checkpoint ); précédent : 001C44; suivant : 001C46Impaired cardiovascular autonomic function in Parkinson's disease with visual hallucinations.
Auteurs : Hisayoshi Oka [Japon] ; Masayuki Yoshioka ; Kenji Onouchi ; Masayo Morita ; Soichiro Mochio ; Masahiko Suzuki ; Toshiaki Hirai ; Mitsuyoshi Urashima ; Kiyoharu InoueSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- 3-Iodobenzylguanidine (diagnostic use), Aged, Aged, 80 and over, Analysis of Variance, Autonomic Nervous System Diseases (etiology), Autonomic Nervous System Diseases (radionuclide imaging), Blood Pressure (physiology), Cardiovascular Diseases (etiology), Cardiovascular Diseases (radionuclide imaging), Female, Hallucinations (complications), Humans, Male, Middle Aged, Norepinephrine (blood), Parkinson Disease (complications), Radiopharmaceuticals (diagnostic use), Tilt-Table Test.
- MESH :
- chemical , blood : Norepinephrine.
- chemical , diagnostic use : 3-Iodobenzylguanidine, Radiopharmaceuticals.
- complications : Hallucinations, Parkinson Disease.
- etiology : Autonomic Nervous System Diseases, Cardiovascular Diseases.
- physiology : Blood Pressure.
- radionuclide imaging : Autonomic Nervous System Diseases, Cardiovascular Diseases.
- Aged, Aged, 80 and over, Analysis of Variance, Female, Humans, Male, Middle Aged, Tilt-Table Test.
Abstract
We assessed the relations of visual hallucinations (VH) to cardiovascular autonomic dysfunction in patients with Parkinson's disease (PD). The subjects were 37 patients without VH (VH(-)) and 31 with VH (VH(+)). Autonomic function was evaluated on the basis of cardiac 123-radioiodinated metaiodobenzylguanidine (123I-MIBG) uptake and hemodynamic testing with Valsalva maneuver. Systolic blood pressure (SBP) and plasma norepinephrine concentrations (NE) were measured by tilt-table testing. 123I-MIBG uptake was lower in VH(+) than VH(-). Hemodynamic studies showed that VH(-) had only cardiac sympathetic and parasympathetic dysfunction, while VH(+) additionally had reduced vasomotor sympathetic functions. The fall in SBP during tilt-table testing was greater in VH(+) than VH(-). NE and its difference in the supine and upright positions were decreased in VH(+). We conclude that cardiac and vasomotor sympathetic dysfunction is more severe in VH(+) than in VH(-). Severe dysfunction in PD with VH is probably attributed to Lewy-body lesions or neuronal loss in sympathetic ganglia, the central autonomic system, or both.
DOI: 10.1002/mds.21581
PubMed: 17516497
Affiliations:
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sortKey="Morita, Masayo" sort="Morita, Masayo" uniqKey="Morita M" first="Masayo" last="Morita">Masayo Morita</name></author><author><name sortKey="Mochio, Soichiro" sort="Mochio, Soichiro" uniqKey="Mochio S" first="Soichiro" last="Mochio">Soichiro Mochio</name></author><author><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name></author><author><name sortKey="Hirai, Toshiaki" sort="Hirai, Toshiaki" uniqKey="Hirai T" first="Toshiaki" last="Hirai">Toshiaki Hirai</name></author><author><name sortKey="Urashima, Mitsuyoshi" sort="Urashima, Mitsuyoshi" uniqKey="Urashima M" first="Mitsuyoshi" last="Urashima">Mitsuyoshi Urashima</name></author><author><name sortKey="Inoue, Kiyoharu" sort="Inoue, Kiyoharu" uniqKey="Inoue K" first="Kiyoharu" last="Inoue">Kiyoharu Inoue</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21581</idno><idno type="RBID">pubmed:17516497</idno><idno type="pmid">17516497</idno><idno type="wicri:Area/PubMed/Corpus">002694</idno><idno type="wicri:Area/PubMed/Curation">002694</idno><idno type="wicri:Area/PubMed/Checkpoint">002776</idno><idno type="wicri:Area/Ncbi/Merge">001C45</idno><idno type="wicri:Area/Ncbi/Curation">001C45</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impaired cardiovascular autonomic function in Parkinson's disease with visual hallucinations.</title><author><name sortKey="Oka, Hisayoshi" sort="Oka, Hisayoshi" uniqKey="Oka H" first="Hisayoshi" last="Oka">Hisayoshi Oka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Jikei University School of Medicine, Tokyo, Japan. h.oka@jikei.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Jikei University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Yoshioka, Masayuki" sort="Yoshioka, Masayuki" uniqKey="Yoshioka M" first="Masayuki" last="Yoshioka">Masayuki Yoshioka</name></author><author><name sortKey="Onouchi, Kenji" sort="Onouchi, Kenji" uniqKey="Onouchi K" first="Kenji" last="Onouchi">Kenji Onouchi</name></author><author><name sortKey="Morita, Masayo" sort="Morita, Masayo" uniqKey="Morita M" first="Masayo" last="Morita">Masayo Morita</name></author><author><name sortKey="Mochio, Soichiro" sort="Mochio, Soichiro" uniqKey="Mochio S" first="Soichiro" last="Mochio">Soichiro Mochio</name></author><author><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name></author><author><name sortKey="Hirai, Toshiaki" sort="Hirai, Toshiaki" uniqKey="Hirai T" first="Toshiaki" last="Hirai">Toshiaki Hirai</name></author><author><name sortKey="Urashima, Mitsuyoshi" sort="Urashima, Mitsuyoshi" uniqKey="Urashima M" first="Mitsuyoshi" last="Urashima">Mitsuyoshi Urashima</name></author><author><name sortKey="Inoue, Kiyoharu" sort="Inoue, Kiyoharu" uniqKey="Inoue K" first="Kiyoharu" last="Inoue">Kiyoharu Inoue</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3-Iodobenzylguanidine (diagnostic use)</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Autonomic Nervous System Diseases (etiology)</term><term>Autonomic Nervous System Diseases (radionuclide imaging)</term><term>Blood Pressure (physiology)</term><term>Cardiovascular Diseases (etiology)</term><term>Cardiovascular Diseases (radionuclide imaging)</term><term>Female</term><term>Hallucinations (complications)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Norepinephrine (blood)</term><term>Parkinson Disease (complications)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Tilt-Table Test</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Norepinephrine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>3-Iodobenzylguanidine</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hallucinations</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tilt-Table Test</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the relations of visual hallucinations (VH) to cardiovascular autonomic dysfunction in patients with Parkinson's disease (PD). The subjects were 37 patients without VH (VH(-)) and 31 with VH (VH(+)). Autonomic function was evaluated on the basis of cardiac 123-radioiodinated metaiodobenzylguanidine (123I-MIBG) uptake and hemodynamic testing with Valsalva maneuver. Systolic blood pressure (SBP) and plasma norepinephrine concentrations (NE) were measured by tilt-table testing. 123I-MIBG uptake was lower in VH(+) than VH(-). Hemodynamic studies showed that VH(-) had only cardiac sympathetic and parasympathetic dysfunction, while VH(+) additionally had reduced vasomotor sympathetic functions. The fall in SBP during tilt-table testing was greater in VH(+) than VH(-). NE and its difference in the supine and upright positions were decreased in VH(+). We conclude that cardiac and vasomotor sympathetic dysfunction is more severe in VH(+) than in VH(-). Severe dysfunction in PD with VH is probably attributed to Lewy-body lesions or neuronal loss in sympathetic ganglia, the central autonomic system, or both.</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Hirai, Toshiaki" sort="Hirai, Toshiaki" uniqKey="Hirai T" first="Toshiaki" last="Hirai">Toshiaki Hirai</name><name sortKey="Inoue, Kiyoharu" sort="Inoue, Kiyoharu" uniqKey="Inoue K" first="Kiyoharu" last="Inoue">Kiyoharu Inoue</name><name sortKey="Mochio, Soichiro" sort="Mochio, Soichiro" uniqKey="Mochio S" first="Soichiro" last="Mochio">Soichiro Mochio</name><name sortKey="Morita, Masayo" sort="Morita, Masayo" uniqKey="Morita M" first="Masayo" last="Morita">Masayo Morita</name><name sortKey="Onouchi, Kenji" sort="Onouchi, Kenji" uniqKey="Onouchi K" first="Kenji" last="Onouchi">Kenji Onouchi</name><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name><name sortKey="Urashima, Mitsuyoshi" sort="Urashima, Mitsuyoshi" uniqKey="Urashima M" first="Mitsuyoshi" last="Urashima">Mitsuyoshi Urashima</name><name sortKey="Yoshioka, Masayuki" sort="Yoshioka, Masayuki" uniqKey="Yoshioka M" first="Masayuki" last="Yoshioka">Masayuki Yoshioka</name></noCountry><country name="Japon"><noRegion><name sortKey="Oka, Hisayoshi" sort="Oka, Hisayoshi" uniqKey="Oka H" first="Hisayoshi" last="Oka">Hisayoshi Oka</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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