Pathophysiological concepts of restless legs syndrome.
Identifieur interne : 001C39 ( Ncbi/Checkpoint ); précédent : 001C38; suivant : 001C40Pathophysiological concepts of restless legs syndrome.
Auteurs : Walter Paulus [Allemagne] ; Pascal Dowling ; Roselyne Rijsman ; Karin Stiasny-Kolster ; Claudia Trenkwalder ; Al De WeerdSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Dopamine.
- metabolism : Corpus Striatum.
- methods : Diagnostic Imaging.
- pathology : Corpus Striatum, Restless Legs Syndrome.
- physiopathology : Restless Legs Syndrome.
- Humans.
Abstract
Pathophysiological concepts of restless legs syndrome (RLS) are based mainly on neuroimaging and on neurophysiological data. Furthermore treatment effects contribute essentially to the present understanding of the disease, unless the genetic progress expected in the near future will clarify substantially open issues. The concept agreed on assumes a dysfunction of the dopaminergic system, possibly on the level of striatal and/or spinal dopamine receptors, and the A11 neuron group localized in the hypothalamus as an integrated part of the system. These neurons modulate spinal excitability, alterations of which in turn affect sensory processing predominantly of leg afferents in brain stem structures. Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H-reflex testing, and quantitative sensory testing.
DOI: 10.1002/mds.21533
PubMed: 17516488
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002700
- to stream PubMed, to step Curation: 002700
- to stream PubMed, to step Checkpoint: 002656
- to stream Ncbi, to step Merge: 001C39
- to stream Ncbi, to step Curation: 001C39
Links to Exploration step
pubmed:17516488Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathophysiological concepts of restless legs syndrome.</title><author><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany. wpaulus@med.uni-goettingen.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Neurophysiology, University of Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Dowling, Pascal" sort="Dowling, Pascal" uniqKey="Dowling P" first="Pascal" last="Dowling">Pascal Dowling</name></author><author><name sortKey="Rijsman, Roselyne" sort="Rijsman, Roselyne" uniqKey="Rijsman R" first="Roselyne" last="Rijsman">Roselyne Rijsman</name></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21533</idno><idno type="RBID">pubmed:17516488</idno><idno type="pmid">17516488</idno><idno type="wicri:Area/PubMed/Corpus">002700</idno><idno type="wicri:Area/PubMed/Curation">002700</idno><idno type="wicri:Area/PubMed/Checkpoint">002656</idno><idno type="wicri:Area/Ncbi/Merge">001C39</idno><idno type="wicri:Area/Ncbi/Curation">001C39</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pathophysiological concepts of restless legs syndrome.</title><author><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany. wpaulus@med.uni-goettingen.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Neurophysiology, University of Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Dowling, Pascal" sort="Dowling, Pascal" uniqKey="Dowling P" first="Pascal" last="Dowling">Pascal Dowling</name></author><author><name sortKey="Rijsman, Roselyne" sort="Rijsman, Roselyne" uniqKey="Rijsman R" first="Roselyne" last="Rijsman">Roselyne Rijsman</name></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (pathology)</term><term>Diagnostic Imaging (methods)</term><term>Dopamine (metabolism)</term><term>Humans</term><term>Restless Legs Syndrome (pathology)</term><term>Restless Legs Syndrome (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathophysiological concepts of restless legs syndrome (RLS) are based mainly on neuroimaging and on neurophysiological data. Furthermore treatment effects contribute essentially to the present understanding of the disease, unless the genetic progress expected in the near future will clarify substantially open issues. The concept agreed on assumes a dysfunction of the dopaminergic system, possibly on the level of striatal and/or spinal dopamine receptors, and the A11 neuron group localized in the hypothalamus as an integrated part of the system. These neurons modulate spinal excitability, alterations of which in turn affect sensory processing predominantly of leg afferents in brain stem structures. Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H-reflex testing, and quantitative sensory testing.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Göttingen</li></settlement></list><tree><noCountry><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name><name sortKey="Dowling, Pascal" sort="Dowling, Pascal" uniqKey="Dowling P" first="Pascal" last="Dowling">Pascal Dowling</name><name sortKey="Rijsman, Roselyne" sort="Rijsman, Roselyne" uniqKey="Rijsman R" first="Roselyne" last="Rijsman">Roselyne Rijsman</name><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></noCountry><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C39 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001C39 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:17516488
|texte= Pathophysiological concepts of restless legs syndrome.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:17516488" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |