State of the art in restless legs syndrome therapy: practice recommendations for treating restless legs syndrome.
Identifieur interne : 001C16 ( Ncbi/Checkpoint ); précédent : 001C15; suivant : 001C17State of the art in restless legs syndrome therapy: practice recommendations for treating restless legs syndrome.
Auteurs : Wolfgang H. Oertel [Allemagne] ; Claudia Trenkwalder ; Marco Zucconi ; Heike Benes ; Diego Garcia Borreguero ; Claudio Bassetti ; Markku Partinen ; Luigi Ferini-Strambi ; Karin Stiasny-KolsterSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , deficiency : Iron.
- chemical , therapeutic use : Dopamine Agents, Iron.
- drug therapy : Restless Legs Syndrome.
- Algorithms, Humans.
Abstract
Dopaminergic agents are the best-studied agents and are considered first-line treatment of restless legs syndrome (RLS). Extensive data are available for levodopa, pramipexole, and ropinirole, which have approval for the indication RLS, and to a smaller extent for cabergoline, pergolide, and rotigotine. Apart from one recent study, comparing two active drugs (levodopa and cabergoline), no comparative studies have been published. The individual treatment regimen with the most appropriate agent concerning efficacy and side effects has to be selected by the treating physician. On the basis of these clinical trials and expert opinion of the authors, a treatment algorithm is proposed to support the search for the optimal individual treatment. Opioids and anticonvulsants such as gabapentine are second-line options in individual patients. Iron substitution is justified in people with iron deficiency related RLS (ferritin concentration lower than 50 microg/L).
DOI: 10.1002/mds.21545
PubMed: 17516455
Affiliations:
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Oertel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps-University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps-University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="Zucconi, Marco" sort="Zucconi, Marco" uniqKey="Zucconi M" first="Marco" last="Zucconi">Marco Zucconi</name></author><author><name sortKey="Benes, Heike" sort="Benes, Heike" uniqKey="Benes H" first="Heike" last="Benes">Heike Benes</name></author><author><name sortKey="Borreguero, Diego Garcia" sort="Borreguero, Diego Garcia" uniqKey="Borreguero D" first="Diego Garcia" last="Borreguero">Diego Garcia Borreguero</name></author><author><name sortKey="Bassetti, Claudio" sort="Bassetti, Claudio" uniqKey="Bassetti C" first="Claudio" last="Bassetti">Claudio Bassetti</name></author><author><name sortKey="Partinen, Markku" sort="Partinen, Markku" uniqKey="Partinen M" first="Markku" last="Partinen">Markku Partinen</name></author><author><name sortKey="Ferini Strambi, Luigi" sort="Ferini Strambi, Luigi" uniqKey="Ferini Strambi L" first="Luigi" last="Ferini-Strambi">Luigi Ferini-Strambi</name></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21545</idno><idno type="RBID">pubmed:17516455</idno><idno type="pmid">17516455</idno><idno type="wicri:Area/PubMed/Corpus">002723</idno><idno type="wicri:Area/PubMed/Curation">002723</idno><idno type="wicri:Area/PubMed/Checkpoint">002542</idno><idno type="wicri:Area/Ncbi/Merge">001C16</idno><idno type="wicri:Area/Ncbi/Curation">001C16</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">State of the art in restless legs syndrome therapy: practice recommendations for treating restless legs syndrome.</title><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps-University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps-University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="Zucconi, Marco" sort="Zucconi, Marco" uniqKey="Zucconi M" first="Marco" last="Zucconi">Marco Zucconi</name></author><author><name sortKey="Benes, Heike" sort="Benes, Heike" uniqKey="Benes H" first="Heike" last="Benes">Heike Benes</name></author><author><name sortKey="Borreguero, Diego Garcia" sort="Borreguero, Diego Garcia" uniqKey="Borreguero D" first="Diego Garcia" last="Borreguero">Diego Garcia Borreguero</name></author><author><name sortKey="Bassetti, Claudio" sort="Bassetti, Claudio" uniqKey="Bassetti C" first="Claudio" last="Bassetti">Claudio Bassetti</name></author><author><name sortKey="Partinen, Markku" sort="Partinen, Markku" uniqKey="Partinen M" first="Markku" last="Partinen">Markku Partinen</name></author><author><name sortKey="Ferini Strambi, Luigi" sort="Ferini Strambi, Luigi" uniqKey="Ferini Strambi L" first="Luigi" last="Ferini-Strambi">Luigi Ferini-Strambi</name></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Dopamine Agents (therapeutic use)</term><term>Humans</term><term>Iron (deficiency)</term><term>Iron (therapeutic use)</term><term>Restless Legs Syndrome (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Iron</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agents</term><term>Iron</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopaminergic agents are the best-studied agents and are considered first-line treatment of restless legs syndrome (RLS). Extensive data are available for levodopa, pramipexole, and ropinirole, which have approval for the indication RLS, and to a smaller extent for cabergoline, pergolide, and rotigotine. Apart from one recent study, comparing two active drugs (levodopa and cabergoline), no comparative studies have been published. The individual treatment regimen with the most appropriate agent concerning efficacy and side effects has to be selected by the treating physician. On the basis of these clinical trials and expert opinion of the authors, a treatment algorithm is proposed to support the search for the optimal individual treatment. Opioids and anticonvulsants such as gabapentine are second-line options in individual patients. Iron substitution is justified in people with iron deficiency related RLS (ferritin concentration lower than 50 microg/L).</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><noCountry><name sortKey="Bassetti, Claudio" sort="Bassetti, Claudio" uniqKey="Bassetti C" first="Claudio" last="Bassetti">Claudio Bassetti</name><name sortKey="Benes, Heike" sort="Benes, Heike" uniqKey="Benes H" first="Heike" last="Benes">Heike Benes</name><name sortKey="Borreguero, Diego Garcia" sort="Borreguero, Diego Garcia" uniqKey="Borreguero D" first="Diego Garcia" last="Borreguero">Diego Garcia Borreguero</name><name sortKey="Ferini Strambi, Luigi" sort="Ferini Strambi, Luigi" uniqKey="Ferini Strambi L" first="Luigi" last="Ferini-Strambi">Luigi Ferini-Strambi</name><name sortKey="Partinen, Markku" sort="Partinen, Markku" uniqKey="Partinen M" first="Markku" last="Partinen">Markku Partinen</name><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><name sortKey="Zucconi, Marco" sort="Zucconi, Marco" uniqKey="Zucconi M" first="Marco" last="Zucconi">Marco Zucconi</name></noCountry><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. 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