Short-term cortical plasticity in patients with dystonia: a study with repetitive transcranial magnetic stimulation.
Identifieur interne : 001C12 ( Ncbi/Checkpoint ); précédent : 001C11; suivant : 001C13Short-term cortical plasticity in patients with dystonia: a study with repetitive transcranial magnetic stimulation.
Auteurs : Francesca Gilio [Italie] ; Antonio Suppa ; Matteo Bologna ; Cinzia Lorenzano ; Giovanni Fabbrini ; Alfredo BerardelliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Case-Control Studies, Cerebral Cortex (physiopathology), Cerebral Cortex (radiation effects), Dose-Response Relationship, Radiation, Dystonia (pathology), Dystonia (physiopathology), Electric Stimulation (methods), Evoked Potentials, Motor (physiology), Evoked Potentials, Motor (radiation effects), Female, Humans, Male, Middle Aged, Neuronal Plasticity (physiology), Neuronal Plasticity (radiation effects), Transcranial Magnetic Stimulation.
- MESH :
- methods : Electric Stimulation.
- pathology : Dystonia.
- physiology : Evoked Potentials, Motor, Neuronal Plasticity.
- physiopathology : Cerebral Cortex, Dystonia.
- radiation effects : Cerebral Cortex, Evoked Potentials, Motor, Neuronal Plasticity.
- Adult, Aged, Analysis of Variance, Case-Control Studies, Dose-Response Relationship, Radiation, Female, Humans, Male, Middle Aged, Transcranial Magnetic Stimulation.
Abstract
Repetitive transcranial magnetic stimulation (rTMS) delivered at 5 Hz frequency and suprathreshold (RMT) intensity produces a progressive facilitation of motor-evoked potential (MEP) amplitude that outlasts the end of stimulation. This phenomenon is related to a short-term enhancement of cortical excitatory interneurones. In this study, we investigated whether 5 Hz-rTMS elicits similar MEP facilitation during stimulation and similar facilitatory after-effects in patients with upper limb dystonia and healthy subjects. Trains of 5, 10, and 20 stimuli were delivered at 120% RMT over the primary motor cortex with the subjects at rest. rTMS-trains were followed by single test stimuli delivered at various interstimulus intervals (0.5-10 s) at 120% RMT using a conditioning-test paradigm. Single conditioning stimuli were also delivered. The effects of suprathreshold 1 Hz-rTMS were also tested. The MEP amplitude during the course of the trains and of the test stimuli was measured. In control experiments, we investigated the role of the afferent inputs elicited by muscle twitches after ulnar nerve stimulation on the MEP amplitude. In patients and healthy subjects, MEP amplitude increased significantly during the course of 5 Hz-trains. In both groups the MEP facilitation outlasted the end of 5 Hz-rTMS, however the facilitatory after-effects were more pronounced and lasted longer in patients than in healthy subjects. MEP amplitudes during and after 1 Hz-rTMS remained unchanged. Ulnar nerve stimulation did not change the test MEP amplitude. We conclude that in patients with upper limb dystonia there is an abnormal recovery from MEP facilitation after suprathreshold 5 Hz-rTMS suggesting an abnormal pattern of short-term cortical plasticity.
DOI: 10.1002/mds.21465
PubMed: 17516450
Affiliations:
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uniqKey="Bologna M" first="Matteo" last="Bologna">Matteo Bologna</name></author><author><name sortKey="Lorenzano, Cinzia" sort="Lorenzano, Cinzia" uniqKey="Lorenzano C" first="Cinzia" last="Lorenzano">Cinzia Lorenzano</name></author><author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21465</idno><idno type="RBID">pubmed:17516450</idno><idno type="pmid">17516450</idno><idno type="wicri:Area/PubMed/Corpus">002727</idno><idno type="wicri:Area/PubMed/Curation">002727</idno><idno type="wicri:Area/PubMed/Checkpoint">002562</idno><idno type="wicri:Area/Ncbi/Merge">001C12</idno><idno type="wicri:Area/Ncbi/Curation">001C12</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Short-term cortical plasticity in patients with dystonia: a study with repetitive transcranial magnetic stimulation.</title><author><name sortKey="Gilio, Francesca" sort="Gilio, Francesca" uniqKey="Gilio F" first="Francesca" last="Gilio">Francesca Gilio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome La Sapienza, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome La Sapienza, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Suppa, Antonio" sort="Suppa, Antonio" uniqKey="Suppa A" first="Antonio" last="Suppa">Antonio Suppa</name></author><author><name sortKey="Bologna, Matteo" sort="Bologna, Matteo" uniqKey="Bologna M" first="Matteo" last="Bologna">Matteo Bologna</name></author><author><name sortKey="Lorenzano, Cinzia" sort="Lorenzano, Cinzia" uniqKey="Lorenzano C" first="Cinzia" last="Lorenzano">Cinzia Lorenzano</name></author><author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Cerebral Cortex (physiopathology)</term><term>Cerebral Cortex (radiation effects)</term><term>Dose-Response Relationship, Radiation</term><term>Dystonia (pathology)</term><term>Dystonia (physiopathology)</term><term>Electric Stimulation (methods)</term><term>Evoked Potentials, Motor (physiology)</term><term>Evoked Potentials, Motor (radiation effects)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuronal Plasticity (physiology)</term><term>Neuronal Plasticity (radiation effects)</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Neuronal Plasticity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Cerebral Cortex</term><term>Evoked Potentials, Motor</term><term>Neuronal Plasticity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Dose-Response Relationship, Radiation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Repetitive transcranial magnetic stimulation (rTMS) delivered at 5 Hz frequency and suprathreshold (RMT) intensity produces a progressive facilitation of motor-evoked potential (MEP) amplitude that outlasts the end of stimulation. This phenomenon is related to a short-term enhancement of cortical excitatory interneurones. In this study, we investigated whether 5 Hz-rTMS elicits similar MEP facilitation during stimulation and similar facilitatory after-effects in patients with upper limb dystonia and healthy subjects. Trains of 5, 10, and 20 stimuli were delivered at 120% RMT over the primary motor cortex with the subjects at rest. rTMS-trains were followed by single test stimuli delivered at various interstimulus intervals (0.5-10 s) at 120% RMT using a conditioning-test paradigm. Single conditioning stimuli were also delivered. The effects of suprathreshold 1 Hz-rTMS were also tested. The MEP amplitude during the course of the trains and of the test stimuli was measured. In control experiments, we investigated the role of the afferent inputs elicited by muscle twitches after ulnar nerve stimulation on the MEP amplitude. In patients and healthy subjects, MEP amplitude increased significantly during the course of 5 Hz-trains. In both groups the MEP facilitation outlasted the end of 5 Hz-rTMS, however the facilitatory after-effects were more pronounced and lasted longer in patients than in healthy subjects. MEP amplitudes during and after 1 Hz-rTMS remained unchanged. Ulnar nerve stimulation did not change the test MEP amplitude. We conclude that in patients with upper limb dystonia there is an abnormal recovery from MEP facilitation after suprathreshold 5 Hz-rTMS suggesting an abnormal pattern of short-term cortical plasticity.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><noCountry><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><name sortKey="Bologna, Matteo" sort="Bologna, Matteo" uniqKey="Bologna M" first="Matteo" last="Bologna">Matteo Bologna</name><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name><name sortKey="Lorenzano, Cinzia" sort="Lorenzano, Cinzia" uniqKey="Lorenzano C" first="Cinzia" last="Lorenzano">Cinzia Lorenzano</name><name sortKey="Suppa, Antonio" sort="Suppa, Antonio" uniqKey="Suppa A" first="Antonio" last="Suppa">Antonio Suppa</name></noCountry><country name="Italie"><region name="Latium"><name sortKey="Gilio, Francesca" sort="Gilio, Francesca" uniqKey="Gilio F" first="Francesca" last="Gilio">Francesca Gilio</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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