Abnormal affective startle modulation in individuals with psychogenic [corrected] movement disorder.
Identifieur interne : 001B98 ( Ncbi/Checkpoint ); précédent : 001B97; suivant : 001B99Abnormal affective startle modulation in individuals with psychogenic [corrected] movement disorder.
Auteurs : Paul J. Seignourel [États-Unis] ; Kimberly Miller ; Ida Kellison ; Ramon Rodriguez ; Hubert H. Fernandez ; Russell M. Bauer ; Dawn Bowers ; Michael S. OkunSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Anxiety (physiopathology), Case-Control Studies, Depression (physiopathology), Electromyography (methods), Emotions, Female, Humans, Male, Middle Aged, Movement Disorders (physiopathology), Movement Disorders (psychology), Photic Stimulation (methods), Questionnaires, Reaction Time (physiology), Reflex, Startle (physiology), Severity of Illness Index.
- MESH :
- methods : Electromyography, Photic Stimulation.
- physiology : Reaction Time, Reflex, Startle.
- physiopathology : Anxiety, Depression, Movement Disorders.
- psychology : Movement Disorders.
- Adult, Aged, Analysis of Variance, Case-Control Studies, Emotions, Female, Humans, Male, Middle Aged, Questionnaires, Severity of Illness Index.
Abstract
Despite recent advances, psychogenic movement disorder (PMD) remains a poorly understood phenomenon. Emotional functioning and responsiveness to stress are believed to play a role in the development of psychogenic symptoms, but empirical studies examining emotional responsiveness in PMD and other conversion disorders are lacking. We investigated modulation of the startle eyeblink reflex by affective pictures in 12 patients with PMD and 12 age- and education-matched control participants. Participants viewed positive, neutral, and negative pictures, while eyeblink responses to white noise bursts were recorded. Control participants showed the expected pattern of startle modulation, with significant potentiation by negative pictures and slight (nonsignificant) inhibition by positive pictures. In the PMD group, however, both positive and negative pictures yielded significantly greater startle responses than neutral pictures. Depression and anxiety symptomatology did not correlate with startle modulation, and the two groups did not differ in self-reported emotional reactions to the pictures. Our findings suggest that individuals with PMD show aversive physiological reactions to positive as well as negative stimuli. Abnormal affective startle modulation may be used to help distinguish between malingering and PMD. Future studies using larger samples are needed to better understand the role of emotions in conversion disorder.
DOI: 10.1002/mds.21451
PubMed: 17486611
Affiliations:
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Seignourel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA. pseignou@phhp.ufl.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Miller, Kimberly" sort="Miller, Kimberly" uniqKey="Miller K" first="Kimberly" last="Miller">Kimberly Miller</name></author><author><name sortKey="Kellison, Ida" sort="Kellison, Ida" uniqKey="Kellison I" first="Ida" last="Kellison">Ida Kellison</name></author><author><name sortKey="Rodriguez, Ramon" sort="Rodriguez, Ramon" uniqKey="Rodriguez R" first="Ramon" last="Rodriguez">Ramon Rodriguez</name></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name></author><author><name sortKey="Bauer, Russell M" sort="Bauer, Russell M" uniqKey="Bauer R" first="Russell M" last="Bauer">Russell M. Bauer</name></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21451</idno><idno type="RBID">pubmed:17486611</idno><idno type="pmid">17486611</idno><idno type="wicri:Area/PubMed/Corpus">002741</idno><idno type="wicri:Area/PubMed/Curation">002741</idno><idno type="wicri:Area/PubMed/Checkpoint">002A04</idno><idno type="wicri:Area/Ncbi/Merge">001B98</idno><idno type="wicri:Area/Ncbi/Curation">001B98</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Abnormal affective startle modulation in individuals with psychogenic [corrected] movement disorder.</title><author><name sortKey="Seignourel, Paul J" sort="Seignourel, Paul J" uniqKey="Seignourel P" first="Paul J" last="Seignourel">Paul J. Seignourel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA. pseignou@phhp.ufl.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Miller, Kimberly" sort="Miller, Kimberly" uniqKey="Miller K" first="Kimberly" last="Miller">Kimberly Miller</name></author><author><name sortKey="Kellison, Ida" sort="Kellison, Ida" uniqKey="Kellison I" first="Ida" last="Kellison">Ida Kellison</name></author><author><name sortKey="Rodriguez, Ramon" sort="Rodriguez, Ramon" uniqKey="Rodriguez R" first="Ramon" last="Rodriguez">Ramon Rodriguez</name></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name></author><author><name sortKey="Bauer, Russell M" sort="Bauer, Russell M" uniqKey="Bauer R" first="Russell M" last="Bauer">Russell M. Bauer</name></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Anxiety (physiopathology)</term><term>Case-Control Studies</term><term>Depression (physiopathology)</term><term>Electromyography (methods)</term><term>Emotions</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement Disorders (physiopathology)</term><term>Movement Disorders (psychology)</term><term>Photic Stimulation (methods)</term><term>Questionnaires</term><term>Reaction Time (physiology)</term><term>Reflex, Startle (physiology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term><term>Photic Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Reaction Time</term><term>Reflex, Startle</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Anxiety</term><term>Depression</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Emotions</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Questionnaires</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite recent advances, psychogenic movement disorder (PMD) remains a poorly understood phenomenon. Emotional functioning and responsiveness to stress are believed to play a role in the development of psychogenic symptoms, but empirical studies examining emotional responsiveness in PMD and other conversion disorders are lacking. We investigated modulation of the startle eyeblink reflex by affective pictures in 12 patients with PMD and 12 age- and education-matched control participants. Participants viewed positive, neutral, and negative pictures, while eyeblink responses to white noise bursts were recorded. Control participants showed the expected pattern of startle modulation, with significant potentiation by negative pictures and slight (nonsignificant) inhibition by positive pictures. In the PMD group, however, both positive and negative pictures yielded significantly greater startle responses than neutral pictures. Depression and anxiety symptomatology did not correlate with startle modulation, and the two groups did not differ in self-reported emotional reactions to the pictures. Our findings suggest that individuals with PMD show aversive physiological reactions to positive as well as negative stimuli. Abnormal affective startle modulation may be used to help distinguish between malingering and PMD. Future studies using larger samples are needed to better understand the role of emotions in conversion disorder.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><noCountry><name sortKey="Bauer, Russell M" sort="Bauer, Russell M" uniqKey="Bauer R" first="Russell M" last="Bauer">Russell M. Bauer</name><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name><name sortKey="Kellison, Ida" sort="Kellison, Ida" uniqKey="Kellison I" first="Ida" last="Kellison">Ida Kellison</name><name sortKey="Miller, Kimberly" sort="Miller, Kimberly" uniqKey="Miller K" first="Kimberly" last="Miller">Kimberly Miller</name><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name><name sortKey="Rodriguez, Ramon" sort="Rodriguez, Ramon" uniqKey="Rodriguez R" first="Ramon" last="Rodriguez">Ramon Rodriguez</name></noCountry><country name="États-Unis"><region name="Floride"><name sortKey="Seignourel, Paul J" sort="Seignourel, Paul J" uniqKey="Seignourel P" first="Paul J" last="Seignourel">Paul J. 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