Power-law temporal autocorrelation of activity reflects severity of parkinsonism.
Identifieur interne : 001B82 ( Ncbi/Checkpoint ); précédent : 001B81; suivant : 001B83Power-law temporal autocorrelation of activity reflects severity of parkinsonism.
Auteurs : Weidong Pan [Japon] ; Kyoko Ohashi ; Yoshiharu Yamamoto ; Shin KwakSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Parkinsonian Disorders.
- physiology : Motor Activity.
- physiopathology : Parkinsonian Disorders.
- psychology : Parkinsonian Disorders.
- Activities of Daily Living, Adult, Aged, Female, Humans, Male, Middle Aged, Severity of Illness Index, Statistics as Topic.
Abstract
We aimed to obtain a reliable, objective scale representing disease severity for appropriate management of patients with Parkinson's disease (PD). Nineteen patients with PD at the Department of Neurology, Tokyo University Hospital, were classified into mild (n = 10) or severe groups (n = 9) depending on their Hoehn-Yahr scores, and wore accelerometers on their wrists for more than 6 consecutive days. During this time we monitored their subjective assessments of symptom severity and analyzed the power-law exponents (alpha) for local maxima and minima of fluctuations in the activity time series. Statistical comparisons were made between the severe and mild groups and of individual patients on "good condition" and "bad condition" days, as well as between days before and after antiparkinsonism medication. In all patients, the alpha for local maxima was always lower when parkinsonism was mild than when severe. Presence of tremor did not influence the alpha for local maxima. As the lower alpha value for local maxima of fluctuations in activity records reflects more frequent switching behavior from low to high physical activities or the severity of akinesia, actigraph monitoring of parkinsonism, and analysis of its power-law correlation may provide useful objective information for controlling parkinsonism in outpatient clinics and for evaluating new antiparkinsonism drugs.
DOI: 10.1002/mds.21527
PubMed: 17469191
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002757
- to stream PubMed, to step Curation: 002757
- to stream PubMed, to step Checkpoint: 002637
- to stream Ncbi, to step Merge: 001B82
- to stream Ncbi, to step Curation: 001B82
Links to Exploration step
pubmed:17469191Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Power-law temporal autocorrelation of activity reflects severity of parkinsonism.</title>
<author><name sortKey="Pan, Weidong" sort="Pan, Weidong" uniqKey="Pan W" first="Weidong" last="Pan">Weidong Pan</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ohashi, Kyoko" sort="Ohashi, Kyoko" uniqKey="Ohashi K" first="Kyoko" last="Ohashi">Kyoko Ohashi</name>
</author>
<author><name sortKey="Yamamoto, Yoshiharu" sort="Yamamoto, Yoshiharu" uniqKey="Yamamoto Y" first="Yoshiharu" last="Yamamoto">Yoshiharu Yamamoto</name>
</author>
<author><name sortKey="Kwak, Shin" sort="Kwak, Shin" uniqKey="Kwak S" first="Shin" last="Kwak">Shin Kwak</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="doi">10.1002/mds.21527</idno>
<idno type="RBID">pubmed:17469191</idno>
<idno type="pmid">17469191</idno>
<idno type="wicri:Area/PubMed/Corpus">002757</idno>
<idno type="wicri:Area/PubMed/Curation">002757</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002637</idno>
<idno type="wicri:Area/Ncbi/Merge">001B82</idno>
<idno type="wicri:Area/Ncbi/Curation">001B82</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001B82</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Power-law temporal autocorrelation of activity reflects severity of parkinsonism.</title>
<author><name sortKey="Pan, Weidong" sort="Pan, Weidong" uniqKey="Pan W" first="Weidong" last="Pan">Weidong Pan</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ohashi, Kyoko" sort="Ohashi, Kyoko" uniqKey="Ohashi K" first="Kyoko" last="Ohashi">Kyoko Ohashi</name>
</author>
<author><name sortKey="Yamamoto, Yoshiharu" sort="Yamamoto, Yoshiharu" uniqKey="Yamamoto Y" first="Yoshiharu" last="Yamamoto">Yoshiharu Yamamoto</name>
</author>
<author><name sortKey="Kwak, Shin" sort="Kwak, Shin" uniqKey="Kwak S" first="Shin" last="Kwak">Shin Kwak</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (physiology)</term>
<term>Parkinsonian Disorders (diagnosis)</term>
<term>Parkinsonian Disorders (physiopathology)</term>
<term>Parkinsonian Disorders (psychology)</term>
<term>Severity of Illness Index</term>
<term>Statistics as Topic</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
<term>Statistics as Topic</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We aimed to obtain a reliable, objective scale representing disease severity for appropriate management of patients with Parkinson's disease (PD). Nineteen patients with PD at the Department of Neurology, Tokyo University Hospital, were classified into mild (n = 10) or severe groups (n = 9) depending on their Hoehn-Yahr scores, and wore accelerometers on their wrists for more than 6 consecutive days. During this time we monitored their subjective assessments of symptom severity and analyzed the power-law exponents (alpha) for local maxima and minima of fluctuations in the activity time series. Statistical comparisons were made between the severe and mild groups and of individual patients on "good condition" and "bad condition" days, as well as between days before and after antiparkinsonism medication. In all patients, the alpha for local maxima was always lower when parkinsonism was mild than when severe. Presence of tremor did not influence the alpha for local maxima. As the lower alpha value for local maxima of fluctuations in activity records reflects more frequent switching behavior from low to high physical activities or the severity of akinesia, actigraph monitoring of parkinsonism, and analysis of its power-law correlation may provide useful objective information for controlling parkinsonism in outpatient clinics and for evaluating new antiparkinsonism drugs.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
<settlement><li>Tokyo</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Kwak, Shin" sort="Kwak, Shin" uniqKey="Kwak S" first="Shin" last="Kwak">Shin Kwak</name>
<name sortKey="Ohashi, Kyoko" sort="Ohashi, Kyoko" uniqKey="Ohashi K" first="Kyoko" last="Ohashi">Kyoko Ohashi</name>
<name sortKey="Yamamoto, Yoshiharu" sort="Yamamoto, Yoshiharu" uniqKey="Yamamoto Y" first="Yoshiharu" last="Yamamoto">Yoshiharu Yamamoto</name>
</noCountry>
<country name="Japon"><noRegion><name sortKey="Pan, Weidong" sort="Pan, Weidong" uniqKey="Pan W" first="Weidong" last="Pan">Weidong Pan</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B82 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001B82 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= pubmed:17469191 |texte= Power-law temporal autocorrelation of activity reflects severity of parkinsonism. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:17469191" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |