Pyramidal tract degeneration in multiple system atrophy: the relevance of magnetization transfer imaging.
Identifieur interne : 001975 ( Ncbi/Checkpoint ); précédent : 001974; suivant : 001976Pyramidal tract degeneration in multiple system atrophy: the relevance of magnetization transfer imaging.
Auteurs : Antonio José Da Rocha [Brésil] ; Antonio Carlos Martins Maia ; Carlos Jorge Da Silva ; Flávio Túlio Braga ; Nelson Paes Diniz Fortes Ferreira ; Orlando Graziani Povoas Barsottini ; Henrique Ballalai FerrazSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple System Atrophy (complications), Multiple System Atrophy (pathology), Multiple System Atrophy (physiopathology), Nerve Degeneration (complications), Nerve Degeneration (pathology), Nerve Degeneration (physiopathology), Parkinson Disease, Secondary (diagnosis), Parkinson Disease, Secondary (etiology), Parkinson Disease, Secondary (physiopathology), Pyramidal Tracts (pathology), Reflex, Abnormal (physiology), Severity of Illness Index.
- MESH :
- complications : Multiple System Atrophy, Nerve Degeneration.
- diagnosis : Parkinson Disease, Secondary.
- etiology : Parkinson Disease, Secondary.
- pathology : Multiple System Atrophy, Nerve Degeneration, Pyramidal Tracts.
- physiology : Reflex, Abnormal.
- physiopathology : Multiple System Atrophy, Nerve Degeneration, Parkinson Disease, Secondary.
- Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Severity of Illness Index.
Abstract
The clinical features of multiple system atrophy (MSA) include four domains: autonomic failure/urinary dysfunction, Parkinsonism, cerebellar ataxia, and corticospinal tract dysfunction. Although the diagnosis of definite MSA requires pathological confirmation, magnetic resonance imaging (MRI) studies have been shown to contribute to the diagnosis of MSA. Although pyramidal tract dysfunction is frequent in MSA patients, signs of pyramidal tract involvement are controversially demonstrated by MRI. We evaluated the pyramidal involvement in 10 patients (7 women) with clinically probable MSA, detecting the presence of spasticity, hyperreflexia, and Babinski sign, as well as demonstrating degeneration of the pyramidal tract and primary motor cortex by MRI in all of them. Our article also discusses key radiological features of this syndrome. In MSA, pyramidal tract involvement seems to be more frequent than previously thought, and the clinicoradiological correlation between pyramidal tract dysfunction and degeneration may contribute to the understanding of the clinical hallmarks of MSA. MRI may also add information regarding the differential diagnosis of this syndrome.
DOI: 10.1002/mds.21229
PubMed: 17133514
Affiliations:
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pubmed:17133514Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Pyramidal tract degeneration in multiple system atrophy: the relevance of magnetization transfer imaging.</title>
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<front><div type="abstract" xml:lang="en">The clinical features of multiple system atrophy (MSA) include four domains: autonomic failure/urinary dysfunction, Parkinsonism, cerebellar ataxia, and corticospinal tract dysfunction. Although the diagnosis of definite MSA requires pathological confirmation, magnetic resonance imaging (MRI) studies have been shown to contribute to the diagnosis of MSA. Although pyramidal tract dysfunction is frequent in MSA patients, signs of pyramidal tract involvement are controversially demonstrated by MRI. We evaluated the pyramidal involvement in 10 patients (7 women) with clinically probable MSA, detecting the presence of spasticity, hyperreflexia, and Babinski sign, as well as demonstrating degeneration of the pyramidal tract and primary motor cortex by MRI in all of them. Our article also discusses key radiological features of this syndrome. In MSA, pyramidal tract involvement seems to be more frequent than previously thought, and the clinicoradiological correlation between pyramidal tract dysfunction and degeneration may contribute to the understanding of the clinical hallmarks of MSA. MRI may also add information regarding the differential diagnosis of this syndrome.</div>
</front>
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