Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders.
Identifieur interne : 001973 ( Ncbi/Checkpoint ); précédent : 001972; suivant : 001974Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders.
Auteurs : Christopher Kenney [États-Unis] ; Christine Hunter ; Joseph Jankovic [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Age of Onset, Anti-Dyskinesia Agents (administration & dosage), Anti-Dyskinesia Agents (adverse effects), Anti-Dyskinesia Agents (therapeutic use), Drug Administration Schedule, Drug Tolerance (physiology), Dyskinesia, Drug-Induced (drug therapy), Dyskinesia, Drug-Induced (epidemiology), Dyskinesia, Drug-Induced (physiopathology), Female, Humans, Huntington Disease (epidemiology), Huntington Disease (etiology), Huntington Disease (physiopathology), Hyperkinesis (drug therapy), Hyperkinesis (epidemiology), Hyperkinesis (physiopathology), Male, Middle Aged, Myoclonus (drug therapy), Myoclonus (epidemiology), Myoclonus (physiopathology), Parkinsonian Disorders (drug therapy), Parkinsonian Disorders (epidemiology), Parkinsonian Disorders (physiopathology), Prevalence, Retrospective Studies, Severity of Illness Index, Tetrabenazine (administration & dosage), Tetrabenazine (adverse effects), Tetrabenazine (therapeutic use), Tics (drug therapy), Tics (epidemiology), Tics (physiopathology), Time.
- MESH :
- chemical , administration & dosage : Anti-Dyskinesia Agents, Tetrabenazine.
- chemical , adverse effects : Anti-Dyskinesia Agents, Tetrabenazine.
- chemical , therapeutic use : Anti-Dyskinesia Agents, Tetrabenazine.
- drug therapy : Dyskinesia, Drug-Induced, Hyperkinesis, Myoclonus, Parkinsonian Disorders, Tics.
- epidemiology : Dyskinesia, Drug-Induced, Huntington Disease, Hyperkinesis, Myoclonus, Parkinsonian Disorders, Tics.
- etiology : Huntington Disease.
- physiology : Drug Tolerance.
- physiopathology : Dyskinesia, Drug-Induced, Huntington Disease, Hyperkinesis, Myoclonus, Parkinsonian Disorders, Tics.
- Adult, Age of Onset, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Prevalence, Retrospective Studies, Severity of Illness Index, Time.
Abstract
We sought to review the long-term tolerability of tetrabenazine (TBZ) and seek determinants of tolerability in the treatment of hyperkinetic movement disorders. A retrospective chart review was performed on patients treated with TBZ between 1997 and 2004. Efficacy of TBZ was assessed by a 1- to 5-point response scale (1 = marked reduction in abnormal movements, 5 = worsening). All adverse events (AEs) were captured according to their relationship with study drug. A total of 448 patients (42% male) were treated for a variety of hyperkinesias, including tardive dyskinesia (n = 149), dystonia (n = 132), chorea (n = 98), tics (n = 92), and myoclonus (n = 19). The mean age at onset of the movement disorder was 43.0 +/- 24.2 years, with TBZ starting at a mean age of 50.0 +/- 22.3 years. Patients remained on treatment for a mean of 2.3 +/- 3.4 years. An efficacy response rating of 1 or 2 was sustained in the majority of patients between the first and last visit. Common AEs included drowsiness (25.0%), Parkinsonism (15.4%), depression (7.6%), and akathisia (7.6%). Comparison of log-likelihood ratios revealed that age was a reliable predictor of Parkinsonism (P < 0.0001). TBZ is a safe and effective drug for the long-term treatment of hyperkinetic movement disorders.
DOI: 10.1002/mds.21222
PubMed: 17133512
Affiliations:
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sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21222</idno><idno type="RBID">pubmed:17133512</idno><idno type="pmid">17133512</idno><idno type="wicri:Area/PubMed/Corpus">002966</idno><idno type="wicri:Area/PubMed/Curation">002966</idno><idno type="wicri:Area/PubMed/Checkpoint">002738</idno><idno type="wicri:Area/Ncbi/Merge">001973</idno><idno type="wicri:Area/Ncbi/Curation">001973</idno><idno type="wicri:Area/Ncbi/Checkpoint">001973</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders.</title><author><name sortKey="Kenney, Christopher" sort="Kenney, Christopher" uniqKey="Kenney C" first="Christopher" last="Kenney">Christopher Kenney</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA. kenney@bcm.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Anti-Dyskinesia Agents (administration & dosage)</term><term>Anti-Dyskinesia Agents (adverse effects)</term><term>Anti-Dyskinesia Agents (therapeutic use)</term><term>Drug Administration Schedule</term><term>Drug Tolerance (physiology)</term><term>Dyskinesia, Drug-Induced (drug therapy)</term><term>Dyskinesia, Drug-Induced (epidemiology)</term><term>Dyskinesia, Drug-Induced 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qualifier="etiology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Drug Tolerance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Huntington Disease</term><term>Hyperkinesis</term><term>Myoclonus</term><term>Parkinsonian Disorders</term><term>Tics</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Drug Administration Schedule</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Time</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We sought to review the long-term tolerability of tetrabenazine (TBZ) and seek determinants of tolerability in the treatment of hyperkinetic movement disorders. A retrospective chart review was performed on patients treated with TBZ between 1997 and 2004. Efficacy of TBZ was assessed by a 1- to 5-point response scale (1 = marked reduction in abnormal movements, 5 = worsening). All adverse events (AEs) were captured according to their relationship with study drug. A total of 448 patients (42% male) were treated for a variety of hyperkinesias, including tardive dyskinesia (n = 149), dystonia (n = 132), chorea (n = 98), tics (n = 92), and myoclonus (n = 19). The mean age at onset of the movement disorder was 43.0 +/- 24.2 years, with TBZ starting at a mean age of 50.0 +/- 22.3 years. Patients remained on treatment for a mean of 2.3 +/- 3.4 years. An efficacy response rating of 1 or 2 was sustained in the majority of patients between the first and last visit. Common AEs included drowsiness (25.0%), Parkinsonism (15.4%), depression (7.6%), and akathisia (7.6%). Comparison of log-likelihood ratios revealed that age was a reliable predictor of Parkinsonism (P < 0.0001). TBZ is a safe and effective drug for the long-term treatment of hyperkinetic movement disorders.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><noCountry><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Kenney, Christopher" sort="Kenney, Christopher" uniqKey="Kenney C" first="Christopher" last="Kenney">Christopher Kenney</name></noRegion><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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