Acute effects of immediate and controlled-release levodopa on mood in Parkinson's disease: A double-blind study.
Identifieur interne : 001959 ( Ncbi/Checkpoint ); précédent : 001958; suivant : 001960Acute effects of immediate and controlled-release levodopa on mood in Parkinson's disease: A double-blind study.
Auteurs : Jaime Kulisevsky [Espagne] ; Berta Pascual-Sedano ; Manel Barbanoj ; Alexandre Gironell ; Javier Pagonabarraga ; Carmen García-SánchezSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Administration, Oral, Affect (drug effects), Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (blood), Anxiety (drug therapy), Anxiety (etiology), Case-Control Studies, Cross-Over Studies, Double-Blind Method, Female, Humans, Levodopa (administration & dosage), Levodopa (blood), Male, Middle Aged, Pain Measurement, Parkinson Disease (blood), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Time Factors.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Levodopa.
- chemical , blood : Antiparkinson Agents, Levodopa.
- blood : Parkinson Disease.
- drug effects : Affect.
- drug therapy : Anxiety, Parkinson Disease.
- etiology : Anxiety.
- physiopathology : Parkinson Disease.
- Administration, Oral, Aged, Case-Control Studies, Cross-Over Studies, Double-Blind Method, Female, Humans, Male, Middle Aged, Pain Measurement, Time Factors.
Abstract
Mood fluctuations related to levodopa (LD) dosing are well-known psychiatric complications of Parkinson's disease (PD). No formal studies explored how affective response to LD relates to the type of motor response to oral LD (stable or wearing-off) and to different pharmacokinetic profiles of oral LD. We used an intrasubject randomized double-blind crossover design to study 14 patients (7 stable, 7 wearing-off) who were monitored for motor status, mood, anxiety, and plasma LD levels 1 hour before and 6 hours after an oral dose of immediate-release (IR) and controlled-release LD formulations. Analysis of the dose-response curves showed a significant interaction between the type of motor response and the type of LD. Only the wearing-off patients had a significant mood elevation, and this effect was only significant following challenge with IR LD. Motor status strongly correlated with LD plasma levels and anxiety but not with mood ratings. Mood changes in PD patients are related to the patient's type of motor response to oral LD and also to the kinetic profile of the LD formulation used for dopaminergic replacement.
DOI: 10.1002/mds.21205
PubMed: 17115388
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002980
- to stream PubMed, to step Curation: 002980
- to stream PubMed, to step Checkpoint: 002989
- to stream Ncbi, to step Merge: 001959
- to stream Ncbi, to step Curation: 001959
Links to Exploration step
pubmed:17115388Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acute effects of immediate and controlled-release levodopa on mood in Parkinson's disease: A double-blind study.</title><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="3"><nlm:affiliation>Movement Disorders Unit, Neurology Department, Autonomous University of Barcelona, Barcelona, Spain. jkulisevsky@santpau.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Unit, Neurology Department, Autonomous University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pascual Sedano, Berta" sort="Pascual Sedano, Berta" uniqKey="Pascual Sedano B" first="Berta" last="Pascual-Sedano">Berta Pascual-Sedano</name></author><author><name sortKey="Barbanoj, Manel" sort="Barbanoj, Manel" uniqKey="Barbanoj M" first="Manel" last="Barbanoj">Manel Barbanoj</name></author><author><name sortKey="Gironell, Alexandre" sort="Gironell, Alexandre" uniqKey="Gironell A" first="Alexandre" last="Gironell">Alexandre Gironell</name></author><author><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name></author><author><name sortKey="Garcia Sanchez, Carmen" sort="Garcia Sanchez, Carmen" uniqKey="Garcia Sanchez C" first="Carmen" last="García-Sánchez">Carmen García-Sánchez</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21205</idno><idno type="RBID">pubmed:17115388</idno><idno type="pmid">17115388</idno><idno type="wicri:Area/PubMed/Corpus">002980</idno><idno type="wicri:Area/PubMed/Curation">002980</idno><idno type="wicri:Area/PubMed/Checkpoint">002989</idno><idno type="wicri:Area/Ncbi/Merge">001959</idno><idno type="wicri:Area/Ncbi/Curation">001959</idno><idno type="wicri:Area/Ncbi/Checkpoint">001959</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Acute effects of immediate and controlled-release levodopa on mood in Parkinson's disease: A double-blind study.</title><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="3"><nlm:affiliation>Movement Disorders Unit, Neurology Department, Autonomous University of Barcelona, Barcelona, Spain. jkulisevsky@santpau.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Unit, Neurology Department, Autonomous University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pascual Sedano, Berta" sort="Pascual Sedano, Berta" uniqKey="Pascual Sedano B" first="Berta" last="Pascual-Sedano">Berta Pascual-Sedano</name></author><author><name sortKey="Barbanoj, Manel" sort="Barbanoj, Manel" uniqKey="Barbanoj M" first="Manel" last="Barbanoj">Manel Barbanoj</name></author><author><name sortKey="Gironell, Alexandre" sort="Gironell, Alexandre" uniqKey="Gironell A" first="Alexandre" last="Gironell">Alexandre Gironell</name></author><author><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name></author><author><name sortKey="Garcia Sanchez, Carmen" sort="Garcia Sanchez, Carmen" uniqKey="Garcia Sanchez C" first="Carmen" last="García-Sánchez">Carmen García-Sánchez</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Affect (drug effects)</term><term>Aged</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (blood)</term><term>Anxiety (drug therapy)</term><term>Anxiety (etiology)</term><term>Case-Control Studies</term><term>Cross-Over Studies</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Levodopa (administration & dosage)</term><term>Levodopa (blood)</term><term>Male</term><term>Middle Aged</term><term>Pain Measurement</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Affect</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Anxiety</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Anxiety</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Aged</term><term>Case-Control Studies</term><term>Cross-Over Studies</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pain Measurement</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mood fluctuations related to levodopa (LD) dosing are well-known psychiatric complications of Parkinson's disease (PD). No formal studies explored how affective response to LD relates to the type of motor response to oral LD (stable or wearing-off) and to different pharmacokinetic profiles of oral LD. We used an intrasubject randomized double-blind crossover design to study 14 patients (7 stable, 7 wearing-off) who were monitored for motor status, mood, anxiety, and plasma LD levels 1 hour before and 6 hours after an oral dose of immediate-release (IR) and controlled-release LD formulations. Analysis of the dose-response curves showed a significant interaction between the type of motor response and the type of LD. Only the wearing-off patients had a significant mood elevation, and this effect was only significant following challenge with IR LD. Motor status strongly correlated with LD plasma levels and anxiety but not with mood ratings. Mood changes in PD patients are related to the patient's type of motor response to oral LD and also to the kinetic profile of the LD formulation used for dopaminergic replacement.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><noCountry><name sortKey="Barbanoj, Manel" sort="Barbanoj, Manel" uniqKey="Barbanoj M" first="Manel" last="Barbanoj">Manel Barbanoj</name><name sortKey="Garcia Sanchez, Carmen" sort="Garcia Sanchez, Carmen" uniqKey="Garcia Sanchez C" first="Carmen" last="García-Sánchez">Carmen García-Sánchez</name><name sortKey="Gironell, Alexandre" sort="Gironell, Alexandre" uniqKey="Gironell A" first="Alexandre" last="Gironell">Alexandre Gironell</name><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name><name sortKey="Pascual Sedano, Berta" sort="Pascual Sedano, Berta" uniqKey="Pascual Sedano B" first="Berta" last="Pascual-Sedano">Berta Pascual-Sedano</name></noCountry><country name="Espagne"><region name="Catalogne"><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001959 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001959 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:17115388
|texte= Acute effects of immediate and controlled-release levodopa on mood in Parkinson's disease: A double-blind study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:17115388" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |