Excellent response to apomorphine in Parkinsonism with optic atrophy unresponsive to oral antiparkinsonian medication.
Identifieur interne : 001717 ( Ncbi/Checkpoint ); précédent : 001716; suivant : 001718Excellent response to apomorphine in Parkinsonism with optic atrophy unresponsive to oral antiparkinsonian medication.
Auteurs : Angela Deutschl Nder [Allemagne] ; Friedrich Asmus ; Elena Marelli ; Thomas Klopstock ; Thomas Gasser ; Kai BötzelSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Administration, Oral, Amantadine (administration & dosage), Antiparkinson Agents (administration & dosage), Apomorphine (administration & dosage), Combined Modality Therapy, Deep Brain Stimulation, Dose-Response Relationship, Drug, Drug Resistance, Drug Therapy, Combination, Humans, Hypokinesia (diagnosis), Hypokinesia (drug therapy), Infusions, Intravenous, Injections, Subcutaneous, Levodopa (administration & dosage), Middle Aged, Neurologic Examination (drug effects), Optic Atrophy (diagnosis), Optic Atrophy (drug therapy), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy).
- MESH :
- chemical , administration & dosage : Amantadine, Antiparkinson Agents, Apomorphine, Levodopa.
- diagnosis : Hypokinesia, Optic Atrophy, Parkinson Disease.
- drug effects : Neurologic Examination.
- drug therapy : Hypokinesia, Optic Atrophy, Parkinson Disease.
- Administration, Oral, Combined Modality Therapy, Deep Brain Stimulation, Dose-Response Relationship, Drug, Drug Resistance, Drug Therapy, Combination, Humans, Infusions, Intravenous, Injections, Subcutaneous, Middle Aged.
Abstract
Two patients presented with the cardinal symptoms of Parkinson's disease (PD), which had developed slowly and progressively. One patient underwent brain imaging of the dopaminergic system, the results of which were compatible with PD. However, both patients showed no response to L-dopa or oral dopaminergic medication. They also had optic nerve atrophy of unknown etiology. The severe motor symptoms of both patients were conspicuously alleviated by apomorphine delivered subcutaneously. One patient underwent bilateral subthalamic nucleus deep brain stimulation, which also proved effective.
DOI: 10.1002/mds.20975
PubMed: 16755578
Affiliations:
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Munich</orgName></affiliation></author><author><name sortKey="Asmus, Friedrich" sort="Asmus, Friedrich" uniqKey="Asmus F" first="Friedrich" last="Asmus">Friedrich Asmus</name></author><author><name sortKey="Marelli, Elena" sort="Marelli, Elena" uniqKey="Marelli E" first="Elena" last="Marelli">Elena Marelli</name></author><author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name></author><author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20975</idno><idno type="RBID">pubmed:16755578</idno><idno type="pmid">16755578</idno><idno 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University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Asmus, Friedrich" sort="Asmus, Friedrich" uniqKey="Asmus F" first="Friedrich" last="Asmus">Friedrich Asmus</name></author><author><name sortKey="Marelli, Elena" sort="Marelli, Elena" uniqKey="Marelli E" first="Elena" last="Marelli">Elena Marelli</name></author><author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name></author><author><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Amantadine (administration & dosage)</term><term>Antiparkinson Agents (administration & dosage)</term><term>Apomorphine (administration & dosage)</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Dose-Response Relationship, Drug</term><term>Drug Resistance</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Hypokinesia (diagnosis)</term><term>Hypokinesia (drug therapy)</term><term>Infusions, Intravenous</term><term>Injections, Subcutaneous</term><term>Levodopa (administration & dosage)</term><term>Middle Aged</term><term>Neurologic Examination (drug effects)</term><term>Optic Atrophy (diagnosis)</term><term>Optic Atrophy (drug therapy)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Amantadine</term><term>Antiparkinson Agents</term><term>Apomorphine</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypokinesia</term><term>Optic Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypokinesia</term><term>Optic Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Dose-Response Relationship, 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One patient underwent brain imaging of the dopaminergic system, the results of which were compatible with PD. However, both patients showed no response to L-dopa or oral dopaminergic medication. They also had optic nerve atrophy of unknown etiology. The severe motor symptoms of both patients were conspicuously alleviated by apomorphine delivered subcutaneously. One patient underwent bilateral subthalamic nucleus deep brain stimulation, which also proved effective.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><noCountry><name sortKey="Asmus, Friedrich" sort="Asmus, Friedrich" uniqKey="Asmus F" first="Friedrich" last="Asmus">Friedrich Asmus</name><name sortKey="Botzel, Kai" sort="Botzel, Kai" uniqKey="Botzel K" first="Kai" last="Bötzel">Kai Bötzel</name><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><name sortKey="Marelli, Elena" sort="Marelli, Elena" uniqKey="Marelli E" first="Elena" last="Marelli">Elena Marelli</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Deutschl Nder, Angela" sort="Deutschl Nder, Angela" uniqKey="Deutschl Nder A" first="Angela" last="Deutschl Nder">Angela Deutschl Nder</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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