Abnormal conduction in corticospinal pathways in Wilson's disease: investigation of nine cases with magnetic brain stimulation.
Identifieur interne : 001638 ( Ncbi/Checkpoint ); précédent : 001637; suivant : 001639Abnormal conduction in corticospinal pathways in Wilson's disease: investigation of nine cases with magnetic brain stimulation.
Auteurs : B U Meyer [Allemagne] ; T C Britton ; C. Bischoff ; J. Machetanz ; R. Benecke ; B. ConradSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1991.
English descriptors
- KwdEn :
- Adult, Electromagnetic Fields, Electromyography, Follow-Up Studies, Hepatolenticular Degeneration (diagnosis), Hepatolenticular Degeneration (drug therapy), Hepatolenticular Degeneration (physiopathology), Humans, Motor Cortex (drug effects), Motor Cortex (physiopathology), Muscle Contraction (drug effects), Muscle Contraction (physiology), Muscles (innervation), Neurologic Examination, Penicillamine (therapeutic use), Pyramidal Tracts (drug effects), Pyramidal Tracts (physiopathology), Synaptic Transmission (drug effects), Synaptic Transmission (physiology).
- MESH :
- chemical , therapeutic use : Penicillamine.
- diagnosis : Hepatolenticular Degeneration.
- drug effects : Motor Cortex, Muscle Contraction, Pyramidal Tracts, Synaptic Transmission.
- drug therapy : Hepatolenticular Degeneration.
- innervation : Muscles.
- physiology : Muscle Contraction, Synaptic Transmission.
- physiopathology : Hepatolenticular Degeneration, Motor Cortex, Pyramidal Tracts.
- Adult, Electromagnetic Fields, Electromyography, Follow-Up Studies, Humans, Neurologic Examination.
Abstract
Electromyographic (EMG) responses evoked by transcranial magnetic brain stimulation were studied in nine patients with Wilson's disease (WD). Six of the nine patients had prolonged central motor latencies (CMLs), reduced amplitude, or absent responses in at least one of the examined muscles. In one patient, abnormal EMG responses normalized following treatment with penicillamine. Pathophysiologically abnormal EMG responses might result from a potentially reversible impairment of corticomotoneuronal pathways and/or a reduced excitability of motoneurons due to basal ganglia dysfunction. The possible pathophysiological mechanisms are discussed.
DOI: 10.1002/mds.870060409
PubMed: 1661845
Affiliations:
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Bischoff</name></author><author><name sortKey="Machetanz, J" sort="Machetanz, J" uniqKey="Machetanz J" first="J" last="Machetanz">J. Machetanz</name></author><author><name sortKey="Benecke, R" sort="Benecke, R" uniqKey="Benecke R" first="R" last="Benecke">R. Benecke</name></author><author><name sortKey="Conrad, B" sort="Conrad, B" uniqKey="Conrad B" first="B" last="Conrad">B. Conrad</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1661845</idno><idno type="pmid">1661845</idno><idno type="doi">10.1002/mds.870060409</idno><idno type="wicri:Area/PubMed/Corpus">004E56</idno><idno type="wicri:Area/PubMed/Curation">004E56</idno><idno type="wicri:Area/PubMed/Checkpoint">004E54</idno><idno type="wicri:Area/Ncbi/Merge">001638</idno><idno type="wicri:Area/Ncbi/Curation">001638</idno><idno type="wicri:Area/Ncbi/Checkpoint">001638</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Abnormal conduction in corticospinal pathways in Wilson's disease: investigation of nine cases with magnetic brain stimulation.</title><author><name sortKey="Meyer, B U" sort="Meyer, B U" uniqKey="Meyer B" first="B U" last="Meyer">B U Meyer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Technical University, Munich, F.R.G.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Department of Neurology, Technical University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Britton, T C" sort="Britton, T C" uniqKey="Britton T" first="T C" last="Britton">T C Britton</name></author><author><name sortKey="Bischoff, C" sort="Bischoff, C" uniqKey="Bischoff C" first="C" last="Bischoff">C. Bischoff</name></author><author><name sortKey="Machetanz, J" sort="Machetanz, J" uniqKey="Machetanz J" first="J" last="Machetanz">J. Machetanz</name></author><author><name sortKey="Benecke, R" sort="Benecke, R" uniqKey="Benecke R" first="R" last="Benecke">R. Benecke</name></author><author><name sortKey="Conrad, B" sort="Conrad, B" uniqKey="Conrad B" first="B" last="Conrad">B. Conrad</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Electromagnetic Fields</term><term>Electromyography</term><term>Follow-Up Studies</term><term>Hepatolenticular Degeneration (diagnosis)</term><term>Hepatolenticular Degeneration (drug therapy)</term><term>Hepatolenticular Degeneration (physiopathology)</term><term>Humans</term><term>Motor Cortex (drug effects)</term><term>Motor Cortex (physiopathology)</term><term>Muscle Contraction (drug effects)</term><term>Muscle Contraction (physiology)</term><term>Muscles (innervation)</term><term>Neurologic Examination</term><term>Penicillamine (therapeutic use)</term><term>Pyramidal Tracts (drug effects)</term><term>Pyramidal Tracts (physiopathology)</term><term>Synaptic Transmission (drug effects)</term><term>Synaptic Transmission (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Penicillamine</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hepatolenticular Degeneration</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Cortex</term><term>Muscle Contraction</term><term>Pyramidal Tracts</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatolenticular Degeneration</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Muscle Contraction</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hepatolenticular Degeneration</term><term>Motor Cortex</term><term>Pyramidal Tracts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Electromagnetic Fields</term><term>Electromyography</term><term>Follow-Up Studies</term><term>Humans</term><term>Neurologic Examination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electromyographic (EMG) responses evoked by transcranial magnetic brain stimulation were studied in nine patients with Wilson's disease (WD). Six of the nine patients had prolonged central motor latencies (CMLs), reduced amplitude, or absent responses in at least one of the examined muscles. In one patient, abnormal EMG responses normalized following treatment with penicillamine. Pathophysiologically abnormal EMG responses might result from a potentially reversible impairment of corticomotoneuronal pathways and/or a reduced excitability of motoneurons due to basal ganglia dysfunction. The possible pathophysiological mechanisms are discussed.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><noCountry><name sortKey="Benecke, R" sort="Benecke, R" uniqKey="Benecke R" first="R" last="Benecke">R. Benecke</name><name sortKey="Bischoff, C" sort="Bischoff, C" uniqKey="Bischoff C" first="C" last="Bischoff">C. Bischoff</name><name sortKey="Britton, T C" sort="Britton, T C" uniqKey="Britton T" first="T C" last="Britton">T C Britton</name><name sortKey="Conrad, B" sort="Conrad, B" uniqKey="Conrad B" first="B" last="Conrad">B. Conrad</name><name sortKey="Machetanz, J" sort="Machetanz, J" uniqKey="Machetanz J" first="J" last="Machetanz">J. Machetanz</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Meyer, B U" sort="Meyer, B U" uniqKey="Meyer B" first="B U" last="Meyer">B U Meyer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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