International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study.
Identifieur interne : 001613 ( Ncbi/Checkpoint ); précédent : 001612; suivant : 001614International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study.
Auteurs : Kallol Ray Chaudhuri [Royaume-Uni] ; Pablo Martinez-Martin ; Anthony H V. Schapira ; Fabrizio Stocchi ; Kapil Sethi ; Per Odin ; Richard G. Brown ; William Koller ; Paolo Barone ; Graeme Macphee ; Linda Kelly ; Martin Rabey ; Doug Macmahon ; Sue Thomas ; William Ondo ; David Rye ; Alison Forbes ; Susanne Tluk ; Vandana Dhawan ; Annette Bowron ; Adrian J. Williams ; Charles W. OlanowSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Female, Health Surveys, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Outcome Assessment (Health Care), Parkinson Disease (diagnosis), Parkinson Disease (epidemiology), Parkinson Disease (psychology), Pilot Projects, Quality of Life, Questionnaires, Sick Role, Sickness Impact Profile.
- MESH :
- diagnosis : Parkinson Disease.
- epidemiology : Parkinson Disease.
- psychology : Parkinson Disease.
- Aged, Aged, 80 and over, Female, Health Surveys, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Outcome Assessment (Health Care), Pilot Projects, Quality of Life, Questionnaires, Sick Role, Sickness Impact Profile.
Abstract
Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.
DOI: 10.1002/mds.20844
PubMed: 16547944
Affiliations:
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pubmed:16547944Le document en format XML
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<author><name sortKey="Chaudhuri, Kallol Ray" sort="Chaudhuri, Kallol Ray" uniqKey="Chaudhuri K" first="Kallol Ray" last="Chaudhuri">Kallol Ray Chaudhuri</name>
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<front><div type="abstract" xml:lang="en">Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.</div>
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