Mechanisms underlying mirror movements in Parkinson's disease: a transcranial magnetic stimulation study.
Identifieur interne : 001608 ( Ncbi/Checkpoint ); précédent : 001607; suivant : 001609Mechanisms underlying mirror movements in Parkinson's disease: a transcranial magnetic stimulation study.
Auteurs : Massimo Cincotta [Italie] ; Alessandra Borgheresi ; Fabrizio Balestrieri ; Fabio Giovannelli ; Aldo Ragazzoni ; Paola Vanni ; Francesco Benvenuti ; Gaetano Zaccara ; Ulf ZiemannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain Mapping, Dominance, Cerebral (physiology), Electromyography, Evoked Potentials, Motor (physiology), Female, Functional Laterality (physiology), Hand (innervation), Humans, Isometric Contraction (physiology), Male, Middle Aged, Motor Activity (physiology), Motor Cortex (physiopathology), Muscle, Skeletal (innervation), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Pyramidal Tracts (physiopathology), Transcranial Magnetic Stimulation.
- MESH :
- diagnosis : Parkinson Disease.
- innervation : Hand, Muscle, Skeletal.
- physiology : Dominance, Cerebral, Evoked Potentials, Motor, Functional Laterality, Isometric Contraction, Motor Activity.
- physiopathology : Motor Cortex, Parkinson Disease, Pyramidal Tracts.
- Aged, Aged, 80 and over, Brain Mapping, Electromyography, Female, Humans, Male, Middle Aged, Transcranial Magnetic Stimulation.
Abstract
The neural mechanisms underlying unintended mirror movements (MMs) of one hand during unimanual movements of the other hand in patients with Parkinson's disease (PD) are largely unexplored. Here we used surface electromyographic (EMG) analysis and focal transcranial magnetic stimulation (TMS) to investigate the pathophysiological substrate of MMs in four PD patients. Surface EMG was recorded from both abductor pollicis brevis (APB) and first dorsal interosseous (FDI) muscles. Cross-correlation EMG analysis revealed no common motor drive to the two APBs during intended unimanual tasks. Focal TMS of either primary motor cortex (M1) elicited normal motor-evoked potentials (MEPs) in the contralateral APB, whereas MEPs were not seen in the ipsilateral hand. During either mirror or voluntary APB contraction, focal TMS of the contralateral M1 produced a long-lasting silent period (SP), whereas stimulation of the ipsilateral M1 produced a short-lasting SP. During either mirror or voluntary finger tapping, 5 Hz repetitive TMS (rTMS) of the contralateral M1 disrupted EMG activity in the target FDI, whereas the effects of rTMS of the ipsilateral M1 were by far slighter. During either mirror or voluntary APB contraction, paired-pulse TMS showed a reduction of short-interval intracortical inhibition in the contralateral M1. These findings provide converging evidence that, in PD, MMs do not depend on unmasking of ipsilateral projections but are explained by motor output along the crossed corticospinal projection from the mirror M1.
DOI: 10.1002/mds.20850
PubMed: 16547917
Affiliations:
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Balestrieri</name></author><author><name sortKey="Giovannelli, Fabio" sort="Giovannelli, Fabio" uniqKey="Giovannelli F" first="Fabio" last="Giovannelli">Fabio Giovannelli</name></author><author><name sortKey="Ragazzoni, Aldo" sort="Ragazzoni, Aldo" uniqKey="Ragazzoni A" first="Aldo" last="Ragazzoni">Aldo Ragazzoni</name></author><author><name sortKey="Vanni, Paola" sort="Vanni, Paola" uniqKey="Vanni P" first="Paola" last="Vanni">Paola Vanni</name></author><author><name sortKey="Benvenuti, Francesco" sort="Benvenuti, Francesco" uniqKey="Benvenuti F" first="Francesco" last="Benvenuti">Francesco Benvenuti</name></author><author><name sortKey="Zaccara, Gaetano" sort="Zaccara, Gaetano" uniqKey="Zaccara G" first="Gaetano" last="Zaccara">Gaetano Zaccara</name></author><author><name sortKey="Ziemann, Ulf" sort="Ziemann, Ulf" uniqKey="Ziemann U" first="Ulf" last="Ziemann">Ulf Ziemann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date 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Santa Maria Nuova Hospital, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Borgheresi, Alessandra" sort="Borgheresi, Alessandra" uniqKey="Borgheresi A" first="Alessandra" last="Borgheresi">Alessandra Borgheresi</name></author><author><name sortKey="Balestrieri, Fabrizio" sort="Balestrieri, Fabrizio" uniqKey="Balestrieri F" first="Fabrizio" last="Balestrieri">Fabrizio Balestrieri</name></author><author><name sortKey="Giovannelli, Fabio" sort="Giovannelli, Fabio" uniqKey="Giovannelli F" first="Fabio" last="Giovannelli">Fabio Giovannelli</name></author><author><name sortKey="Ragazzoni, Aldo" sort="Ragazzoni, Aldo" uniqKey="Ragazzoni A" first="Aldo" last="Ragazzoni">Aldo Ragazzoni</name></author><author><name sortKey="Vanni, Paola" sort="Vanni, Paola" uniqKey="Vanni P" first="Paola" last="Vanni">Paola Vanni</name></author><author><name sortKey="Benvenuti, Francesco" sort="Benvenuti, Francesco" uniqKey="Benvenuti F" first="Francesco" last="Benvenuti">Francesco Benvenuti</name></author><author><name sortKey="Zaccara, Gaetano" sort="Zaccara, Gaetano" uniqKey="Zaccara G" first="Gaetano" last="Zaccara">Gaetano Zaccara</name></author><author><name sortKey="Ziemann, Ulf" sort="Ziemann, Ulf" uniqKey="Ziemann U" first="Ulf" last="Ziemann">Ulf Ziemann</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Dominance, Cerebral (physiology)</term><term>Electromyography</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Hand (innervation)</term><term>Humans</term><term>Isometric Contraction (physiology)</term><term>Male</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Motor Cortex (physiopathology)</term><term>Muscle, Skeletal (innervation)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Pyramidal Tracts (physiopathology)</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Hand</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term><term>Evoked Potentials, Motor</term><term>Functional Laterality</term><term>Isometric Contraction</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term><term>Pyramidal Tracts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The neural mechanisms underlying unintended mirror movements (MMs) of one hand during unimanual movements of the other hand in patients with Parkinson's disease (PD) are largely unexplored. Here we used surface electromyographic (EMG) analysis and focal transcranial magnetic stimulation (TMS) to investigate the pathophysiological substrate of MMs in four PD patients. Surface EMG was recorded from both abductor pollicis brevis (APB) and first dorsal interosseous (FDI) muscles. Cross-correlation EMG analysis revealed no common motor drive to the two APBs during intended unimanual tasks. Focal TMS of either primary motor cortex (M1) elicited normal motor-evoked potentials (MEPs) in the contralateral APB, whereas MEPs were not seen in the ipsilateral hand. During either mirror or voluntary APB contraction, focal TMS of the contralateral M1 produced a long-lasting silent period (SP), whereas stimulation of the ipsilateral M1 produced a short-lasting SP. During either mirror or voluntary finger tapping, 5 Hz repetitive TMS (rTMS) of the contralateral M1 disrupted EMG activity in the target FDI, whereas the effects of rTMS of the ipsilateral M1 were by far slighter. During either mirror or voluntary APB contraction, paired-pulse TMS showed a reduction of short-interval intracortical inhibition in the contralateral M1. These findings provide converging evidence that, in PD, MMs do not depend on unmasking of ipsilateral projections but are explained by motor output along the crossed corticospinal projection from the mirror M1.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Balestrieri, Fabrizio" sort="Balestrieri, Fabrizio" uniqKey="Balestrieri F" first="Fabrizio" last="Balestrieri">Fabrizio Balestrieri</name><name sortKey="Benvenuti, Francesco" sort="Benvenuti, Francesco" uniqKey="Benvenuti F" first="Francesco" last="Benvenuti">Francesco Benvenuti</name><name sortKey="Borgheresi, Alessandra" sort="Borgheresi, Alessandra" uniqKey="Borgheresi A" first="Alessandra" last="Borgheresi">Alessandra Borgheresi</name><name sortKey="Giovannelli, Fabio" sort="Giovannelli, Fabio" uniqKey="Giovannelli F" first="Fabio" last="Giovannelli">Fabio Giovannelli</name><name sortKey="Ragazzoni, Aldo" sort="Ragazzoni, Aldo" uniqKey="Ragazzoni A" first="Aldo" last="Ragazzoni">Aldo Ragazzoni</name><name sortKey="Vanni, Paola" sort="Vanni, Paola" uniqKey="Vanni P" first="Paola" last="Vanni">Paola Vanni</name><name sortKey="Zaccara, Gaetano" sort="Zaccara, Gaetano" uniqKey="Zaccara G" first="Gaetano" last="Zaccara">Gaetano Zaccara</name><name sortKey="Ziemann, Ulf" sort="Ziemann, Ulf" uniqKey="Ziemann U" first="Ulf" last="Ziemann">Ulf Ziemann</name></noCountry><country name="Italie"><noRegion><name sortKey="Cincotta, Massimo" sort="Cincotta, Massimo" uniqKey="Cincotta M" first="Massimo" last="Cincotta">Massimo Cincotta</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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