Association between vestibuloocular reflex suppression during smooth movements of the head and attention deficit in progressive supranuclear palsy.
Identifieur interne : 001588 ( Ncbi/Checkpoint ); précédent : 001587; suivant : 001589Association between vestibuloocular reflex suppression during smooth movements of the head and attention deficit in progressive supranuclear palsy.
Auteurs : Richard P. Di Fabio [États-Unis] ; Cris Zampieri ; Paul Tuite ; Jürgen KonczakSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Attention (physiology), Attention Deficit Disorder with Hyperactivity (diagnosis), Attention Deficit Disorder with Hyperactivity (physiopathology), Cognition Disorders (diagnosis), Cognition Disorders (physiopathology), Female, Fixation, Ocular (physiology), Head Movements (physiology), Humans, Male, Middle Aged, Orientation (physiology), Psychomotor Performance (physiology), Pursuit, Smooth (physiology), Reflex, Vestibulo-Ocular (physiology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (physiopathology).
- MESH :
- diagnosis : Attention Deficit Disorder with Hyperactivity, Cognition Disorders, Supranuclear Palsy, Progressive.
- physiology : Attention, Fixation, Ocular, Head Movements, Orientation, Psychomotor Performance, Pursuit, Smooth, Reflex, Vestibulo-Ocular.
- physiopathology : Attention Deficit Disorder with Hyperactivity, Cognition Disorders, Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.
Abstract
With head movement, suppression of vestibular inputs during visual exploration is necessary not only for reorienting gaze, but also to direct attention to new visual targets. People with progressive supranuclear palsy (PSP) have difficulty suppressing the vestibuloocular reflex (VOR) and it was hypothesized that the magnitude of VOR suppression deficit correlates with the degree of degradation of attention and visuospatial performance. We evaluated cognitive and visuomotor function in 8 subjects with PSP (4 men and 4 women; ages 59-83 years). Gaze control was studied by measuring the accuracy of eye-head coordination during passive vertical and horizontal head-on-trunk movements. Fixation was assessed when subjects viewed either an earth-fixed or head-fixed target. A gaze fixation score (GFS) was calculated to represent the amount of error between eye and head movement in each plane (eye-head root mean square error normalized to the range of head rotation). The vertical but not horizontal GFS during attempted suppression of the VOR was significantly related to attention (r = -0.70; P = 0.05) and visuospatial ability (r = -0.76; P = 0.03). These findings suggest that the ability to suppress the VOR during vertical smooth movements of the head is associated with the magnitude of cognitive deficit in PSP.
DOI: 10.1002/mds.20822
PubMed: 16532447
Affiliations:
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Di Fabio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota 55455, USA. difab001@umn.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota 55455</wicri:regionArea><wicri:noRegion>Minnesota 55455</wicri:noRegion></affiliation></author><author><name sortKey="Zampieri, Cris" sort="Zampieri, Cris" uniqKey="Zampieri C" first="Cris" last="Zampieri">Cris Zampieri</name></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name></author><author><name sortKey="Konczak, Jurgen" sort="Konczak, Jurgen" uniqKey="Konczak J" first="Jürgen" last="Konczak">Jürgen Konczak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20822</idno><idno type="RBID">pubmed:16532447</idno><idno type="pmid">16532447</idno><idno type="wicri:Area/PubMed/Corpus">002D43</idno><idno type="wicri:Area/PubMed/Curation">002D43</idno><idno type="wicri:Area/PubMed/Checkpoint">002E71</idno><idno type="wicri:Area/Ncbi/Merge">001588</idno><idno type="wicri:Area/Ncbi/Curation">001588</idno><idno type="wicri:Area/Ncbi/Checkpoint">001588</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association between vestibuloocular reflex suppression during smooth movements of the head and attention deficit in progressive supranuclear palsy.</title><author><name sortKey="Di Fabio, Richard P" sort="Di Fabio, Richard P" uniqKey="Di Fabio R" first="Richard P" last="Di Fabio">Richard P. Di Fabio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota 55455, USA. difab001@umn.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota 55455</wicri:regionArea><wicri:noRegion>Minnesota 55455</wicri:noRegion></affiliation></author><author><name sortKey="Zampieri, Cris" sort="Zampieri, Cris" uniqKey="Zampieri C" first="Cris" last="Zampieri">Cris Zampieri</name></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name></author><author><name sortKey="Konczak, Jurgen" sort="Konczak, Jurgen" uniqKey="Konczak J" first="Jürgen" last="Konczak">Jürgen Konczak</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Attention (physiology)</term><term>Attention Deficit Disorder with Hyperactivity (diagnosis)</term><term>Attention Deficit Disorder with Hyperactivity (physiopathology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (physiopathology)</term><term>Female</term><term>Fixation, Ocular (physiology)</term><term>Head Movements (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Orientation (physiology)</term><term>Psychomotor Performance (physiology)</term><term>Pursuit, Smooth (physiology)</term><term>Reflex, Vestibulo-Ocular (physiology)</term><term>Supranuclear Palsy, Progressive (diagnosis)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Attention Deficit Disorder with Hyperactivity</term><term>Cognition Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Fixation, Ocular</term><term>Head Movements</term><term>Orientation</term><term>Psychomotor Performance</term><term>Pursuit, Smooth</term><term>Reflex, Vestibulo-Ocular</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Attention Deficit Disorder with Hyperactivity</term><term>Cognition Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">With head movement, suppression of vestibular inputs during visual exploration is necessary not only for reorienting gaze, but also to direct attention to new visual targets. People with progressive supranuclear palsy (PSP) have difficulty suppressing the vestibuloocular reflex (VOR) and it was hypothesized that the magnitude of VOR suppression deficit correlates with the degree of degradation of attention and visuospatial performance. We evaluated cognitive and visuomotor function in 8 subjects with PSP (4 men and 4 women; ages 59-83 years). Gaze control was studied by measuring the accuracy of eye-head coordination during passive vertical and horizontal head-on-trunk movements. Fixation was assessed when subjects viewed either an earth-fixed or head-fixed target. A gaze fixation score (GFS) was calculated to represent the amount of error between eye and head movement in each plane (eye-head root mean square error normalized to the range of head rotation). The vertical but not horizontal GFS during attempted suppression of the VOR was significantly related to attention (r = -0.70; P = 0.05) and visuospatial ability (r = -0.76; P = 0.03). These findings suggest that the ability to suppress the VOR during vertical smooth movements of the head is associated with the magnitude of cognitive deficit in PSP.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Konczak, Jurgen" sort="Konczak, Jurgen" uniqKey="Konczak J" first="Jürgen" last="Konczak">Jürgen Konczak</name><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name><name sortKey="Zampieri, Cris" sort="Zampieri, Cris" uniqKey="Zampieri C" first="Cris" last="Zampieri">Cris Zampieri</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Di Fabio, Richard P" sort="Di Fabio, Richard P" uniqKey="Di Fabio R" first="Richard P" last="Di Fabio">Richard P. Di Fabio</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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