Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.
Identifieur interne : 001511 ( Ncbi/Checkpoint ); précédent : 001510; suivant : 001512Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.
Auteurs : Georgios M. Hadjigeorgiou [Grèce] ; Georgia Xiromerisiou ; Vanessa Gourbali ; Kostantinos Aggelakis ; Nikolaos Scarmeas ; Alexandros Papadimitriou ; Andrew SingletonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
Descripteurs français
- Wicri :
- geographic : Grèce.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Chi-Square Distribution, Confidence Intervals, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Greece (ethnology), Humans, Male, Microsatellite Repeats (genetics), Middle Aged, Odds Ratio, Parkinson Disease (genetics), Parkinson Disease (mortality), Polymorphism, Genetic, Promoter Regions, Genetic, Survival Analysis, alpha-Synuclein (genetics).
- MESH :
- chemical , genetics : alpha-Synuclein.
- geographic , ethnology : Greece.
- genetics : Microsatellite Repeats, Parkinson Disease.
- mortality : Parkinson Disease.
- Adult, Age of Onset, Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Chi-Square Distribution, Confidence Intervals, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Genetic, Promoter Regions, Genetic, Survival Analysis.
Abstract
The alpha-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep1 allele 2 was earlier (3.6 years) compared to noncarriers (adjusted hazard ratio = 2.21; 95% CI = 1.58-3.10). Kaplan-Meier analysis also supported a dosage effect of Rep1 allele 2 on age at onset. For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD.
DOI: 10.1002/mds.20752
PubMed: 16250025
Affiliations:
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<author><name sortKey="Gourbali, Vanessa" sort="Gourbali, Vanessa" uniqKey="Gourbali V" first="Vanessa" last="Gourbali">Vanessa Gourbali</name>
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<author><name sortKey="Aggelakis, Kostantinos" sort="Aggelakis, Kostantinos" uniqKey="Aggelakis K" first="Kostantinos" last="Aggelakis">Kostantinos Aggelakis</name>
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<author><name sortKey="Papadimitriou, Alexandros" sort="Papadimitriou, Alexandros" uniqKey="Papadimitriou A" first="Alexandros" last="Papadimitriou">Alexandros Papadimitriou</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Case-Control Studies</term>
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<term>Parkinson Disease (mortality)</term>
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<term>Case-Control Studies</term>
<term>Chi-Square Distribution</term>
<term>Confidence Intervals</term>
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<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
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<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
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<front><div type="abstract" xml:lang="en">The alpha-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep1 allele 2 was earlier (3.6 years) compared to noncarriers (adjusted hazard ratio = 2.21; 95% CI = 1.58-3.10). Kaplan-Meier analysis also supported a dosage effect of Rep1 allele 2 on age at onset. For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD.</div>
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<name sortKey="Papadimitriou, Alexandros" sort="Papadimitriou, Alexandros" uniqKey="Papadimitriou A" first="Alexandros" last="Papadimitriou">Alexandros Papadimitriou</name>
<name sortKey="Scarmeas, Nikolaos" sort="Scarmeas, Nikolaos" uniqKey="Scarmeas N" first="Nikolaos" last="Scarmeas">Nikolaos Scarmeas</name>
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<name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name>
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