Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe.
Identifieur interne : 001353 ( Ncbi/Checkpoint ); précédent : 001352; suivant : 001354Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe.
Auteurs : Pierre Champy [France] ; Alice Melot ; Vincent Guérineau Eng ; Christophe Gleye ; Djibril Fall ; Gunter U. Höglinger ; Merle Ruberg ; Annie Lannuzel ; Olivier Laprévote ; Alain Laurens ; Reynald HocquemillerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Acetogenins, Annona (chemistry), Annona (toxicity), Chromatography, High Pressure Liquid (methods), Fatty Alcohols (adverse effects), Fatty Alcohols (analysis), Fatty Alcohols (chemistry), Guadeloupe (epidemiology), Humans, Lactones (adverse effects), Lactones (analysis), Lactones (chemistry), Molecular Weight, Parkinsonian Disorders (etiology), Plant Extracts (adverse effects), Plant Extracts (analysis), Plant Extracts (chemistry), Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization (methods).
- MESH :
- chemical , adverse effects : Fatty Alcohols, Lactones, Plant Extracts.
- chemical , analysis : Fatty Alcohols, Lactones, Plant Extracts.
- chemical , chemistry : Fatty Alcohols, Lactones, Plant Extracts.
- chemical : Acetogenins.
- geographic , epidemiology : Guadeloupe.
- chemistry : Annona.
- etiology : Parkinsonian Disorders.
- methods : Chromatography, High Pressure Liquid, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization.
- toxicity : Annona.
- Humans, Molecular Weight.
Abstract
Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix-assisted laser desorption-ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 microg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion.
DOI: 10.1002/mds.20632
PubMed: 16078200
Affiliations:
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Höglinger</name></author><author><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name></author><author><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name></author><author><name sortKey="Laprevote, Olivier" sort="Laprevote, Olivier" uniqKey="Laprevote O" first="Olivier" last="Laprévote">Olivier Laprévote</name></author><author><name sortKey="Laurens, Alain" sort="Laurens, Alain" uniqKey="Laurens A" first="Alain" last="Laurens">Alain Laurens</name></author><author><name sortKey="Hocquemiller, Reynald" sort="Hocquemiller, Reynald" uniqKey="Hocquemiller R" first="Reynald" last="Hocquemiller">Reynald Hocquemiller</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20632</idno><idno type="RBID">pubmed:16078200</idno><idno type="pmid">16078200</idno><idno type="wicri:Area/PubMed/Corpus">002F59</idno><idno type="wicri:Area/PubMed/Curation">002F59</idno><idno type="wicri:Area/PubMed/Checkpoint">002F89</idno><idno type="wicri:Area/Ncbi/Merge">001353</idno><idno type="wicri:Area/Ncbi/Curation">001353</idno><idno type="wicri:Area/Ncbi/Checkpoint">001353</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe.</title><author><name sortKey="Champy, Pierre" sort="Champy, Pierre" uniqKey="Champy P" first="Pierre" last="Champy">Pierre Champy</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique BioCIS, Faculté de Pharmacie Paris XI, Châtenay-Malabry, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Pharmacognosy, UMR 8076 Centre National de la Recherche Scientifique BioCIS, Faculté de Pharmacie Paris XI, Châtenay-Malabry</wicri:regionArea><wicri:noRegion>Châtenay-Malabry</wicri:noRegion><wicri:noRegion>Châtenay-Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Melot, Alice" sort="Melot, Alice" uniqKey="Melot A" first="Alice" last="Melot">Alice Melot</name></author><author><name sortKey="Guerineau Eng, Vincent" sort="Guerineau Eng, Vincent" uniqKey="Guerineau Eng V" first="Vincent" last="Guérineau Eng">Vincent Guérineau Eng</name></author><author><name sortKey="Gleye, Christophe" sort="Gleye, Christophe" uniqKey="Gleye C" first="Christophe" last="Gleye">Christophe Gleye</name></author><author><name sortKey="Fall, Djibril" sort="Fall, Djibril" uniqKey="Fall D" first="Djibril" last="Fall">Djibril Fall</name></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Gunter U" last="Höglinger">Gunter U. Höglinger</name></author><author><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name></author><author><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name></author><author><name sortKey="Laprevote, Olivier" sort="Laprevote, Olivier" uniqKey="Laprevote O" first="Olivier" last="Laprévote">Olivier Laprévote</name></author><author><name sortKey="Laurens, Alain" sort="Laurens, Alain" uniqKey="Laurens A" first="Alain" last="Laurens">Alain Laurens</name></author><author><name sortKey="Hocquemiller, Reynald" sort="Hocquemiller, Reynald" uniqKey="Hocquemiller R" first="Reynald" last="Hocquemiller">Reynald Hocquemiller</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetogenins</term><term>Annona (chemistry)</term><term>Annona (toxicity)</term><term>Chromatography, High Pressure Liquid (methods)</term><term>Fatty Alcohols (adverse effects)</term><term>Fatty Alcohols (analysis)</term><term>Fatty Alcohols (chemistry)</term><term>Guadeloupe (epidemiology)</term><term>Humans</term><term>Lactones (adverse effects)</term><term>Lactones (analysis)</term><term>Lactones (chemistry)</term><term>Molecular Weight</term><term>Parkinsonian Disorders (etiology)</term><term>Plant Extracts (adverse effects)</term><term>Plant Extracts (analysis)</term><term>Plant Extracts (chemistry)</term><term>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Fatty Alcohols</term><term>Lactones</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fatty Alcohols</term><term>Lactones</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fatty Alcohols</term><term>Lactones</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Acetogenins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Guadeloupe</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Annona</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, High Pressure Liquid</term><term>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</term></keywords><keywords scheme="MESH" qualifier="toxicity" xml:lang="en"><term>Annona</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Molecular Weight</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix-assisted laser desorption-ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 microg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Fall, Djibril" sort="Fall, Djibril" uniqKey="Fall D" first="Djibril" last="Fall">Djibril Fall</name><name sortKey="Gleye, Christophe" sort="Gleye, Christophe" uniqKey="Gleye C" first="Christophe" last="Gleye">Christophe Gleye</name><name sortKey="Guerineau Eng, Vincent" sort="Guerineau Eng, Vincent" uniqKey="Guerineau Eng V" first="Vincent" last="Guérineau Eng">Vincent Guérineau Eng</name><name sortKey="Hocquemiller, Reynald" sort="Hocquemiller, Reynald" uniqKey="Hocquemiller R" first="Reynald" last="Hocquemiller">Reynald Hocquemiller</name><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Gunter U" last="Höglinger">Gunter U. Höglinger</name><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><name sortKey="Laprevote, Olivier" sort="Laprevote, Olivier" uniqKey="Laprevote O" first="Olivier" last="Laprévote">Olivier Laprévote</name><name sortKey="Laurens, Alain" sort="Laurens, Alain" uniqKey="Laurens A" first="Alain" last="Laurens">Alain Laurens</name><name sortKey="Melot, Alice" sort="Melot, Alice" uniqKey="Melot A" first="Alice" last="Melot">Alice Melot</name><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name></noCountry><country name="France"><noRegion><name sortKey="Champy, Pierre" sort="Champy, Pierre" uniqKey="Champy P" first="Pierre" last="Champy">Pierre Champy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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