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Parkinson's disease, stroke, and related epidemiology.

Identifieur interne : 001344 ( Ncbi/Checkpoint ); précédent : 001343; suivant : 001345

Parkinson's disease, stroke, and related epidemiology.

Auteurs : Andrew Nataraj [Canada] ; Ali H. Rajput

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.

RBID : pubmed:16037918

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Comorbidity, Cross-Sectional Studies, Essential Tremor (epidemiology), Female, Humans, Male, Parkinson Disease (epidemiology), Prevalence, Severity of Illness Index, Stroke (epidemiology).
MESH :
- epidemiology : Essential Tremor, Parkinson Disease, Stroke.
- Aged, Aged, 80 and over, Comorbidity, Cross-Sectional Studies, Female, Humans, Male, Prevalence, Severity of Illness Index.

Abstract

We investigated the prevalence of cerebrovascular disease and other comorbidities in Parkinson's disease (PD) patients compared to the general population. Five hundred PD patients were chosen randomly from one author's (A.H.R.) database. Age- and sex-matched controls were derived from 270 patients with essential tremor from the same database and from 490 patients in a general practitioner's database. Age, hypertensive status, smoking status, coronary artery disease, orthostatic hypotension, diabetes mellitus, and symptomatic cerebrovascular disease (stroke or transient ischemic attack) were assessed. Statistical analysis was performed using Pearson chi(2) testing and binary logistic regression analysis. The prevalence of coronary artery disease, hypertension, diabetes mellitus, and orthostatic hypotension was similar among groups. The PD group had more patients who never smoked and less current smokers than the other groups. While there were similar frequencies of symptomatic cerebrovascular disease among groups, the prevalence of stroke was lower in PD patients. This difference disappeared upon stratification into groups based on smoking status and in the addition of smoking as a covariate in the multivariate analysis. Diminished smoking in PD patients likely plays a role in our finding of decreased stroke in patients with PD. Increased access to appropriate neurological care and subsequent prevention of stroke after a warning transient ischemic attack may also play a role, as may diminished levels of excitotoxic neurotransmitters in PD patients.

DOI: 10.1002/mds.20608
PubMed: 16037918

Affiliations:

Canada

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pubmed:16037918

Le document en format XML

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<author><name sortKey="Nataraj, Andrew" sort="Nataraj, Andrew" uniqKey="Nataraj A" first="Andrew" last="Nataraj">Andrew Nataraj</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. akynataraj@yahoo.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan</wicri:regionArea>
<wicri:noRegion>Saskatchewan</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. akynataraj@yahoo.ca</nlm:affiliation>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Cross-Sectional Studies</term>
<term>Essential Tremor (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
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<term>Parkinson Disease (epidemiology)</term>
<term>Prevalence</term>
<term>Severity of Illness Index</term>
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<term>Cross-Sectional Studies</term>
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<front><div type="abstract" xml:lang="en">We investigated the prevalence of cerebrovascular disease and other comorbidities in Parkinson's disease (PD) patients compared to the general population. Five hundred PD patients were chosen randomly from one author's (A.H.R.) database. Age- and sex-matched controls were derived from 270 patients with essential tremor from the same database and from 490 patients in a general practitioner's database. Age, hypertensive status, smoking status, coronary artery disease, orthostatic hypotension, diabetes mellitus, and symptomatic cerebrovascular disease (stroke or transient ischemic attack) were assessed. Statistical analysis was performed using Pearson chi(2) testing and binary logistic regression analysis. The prevalence of coronary artery disease, hypertension, diabetes mellitus, and orthostatic hypotension was similar among groups. The PD group had more patients who never smoked and less current smokers than the other groups. While there were similar frequencies of symptomatic cerebrovascular disease among groups, the prevalence of stroke was lower in PD patients. This difference disappeared upon stratification into groups based on smoking status and in the addition of smoking as a covariate in the multivariate analysis. Diminished smoking in PD patients likely plays a role in our finding of decreased stroke in patients with PD. Increased access to appropriate neurological care and subsequent prevention of stroke after a warning transient ischemic attack may also play a role, as may diminished levels of excitotoxic neurotransmitters in PD patients.</div>
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<affiliations><list><country><li>Canada</li>
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<tree><noCountry><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H" last="Rajput">Ali H. Rajput</name>
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<country name="Canada"><noRegion><name sortKey="Nataraj, Andrew" sort="Nataraj, Andrew" uniqKey="Nataraj A" first="Andrew" last="Nataraj">Andrew Nataraj</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Parkinson's disease, stroke, and related epidemiology.

Parkinson's disease, stroke, and related epidemiology.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

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Pour générer des pages wiki