Addiction in Parkinson's disease: impact of subthalamic nucleus deep brain stimulation.
Identifieur interne : 001254 ( Ncbi/Checkpoint ); précédent : 001253; suivant : 001255Addiction in Parkinson's disease: impact of subthalamic nucleus deep brain stimulation.
Auteurs : Tatiana Witjas [France] ; Christelle Baunez ; Jean Marc Henry ; Marie Delfini ; Jean Regis ; André Ali Cherif ; Jean Claude Peragut ; Jean Philippe AzulaySource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- complications : Behavior, Addictive, Parkinson Disease.
- methods : Deep Brain Stimulation.
- radiation effects : Subthalamic Nucleus.
- therapy : Behavior, Addictive, Parkinson Disease.
- Adult, Clinical Protocols, Humans, Male, Middle Aged.
Abstract
In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high-frequency STN stimulation, and this treatment may even cure the addiction.
DOI: 10.1002/mds.20501
PubMed: 15858803
Affiliations:
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sortKey="Delfini, Marie" sort="Delfini, Marie" uniqKey="Delfini M" first="Marie" last="Delfini">Marie Delfini</name></author><author><name sortKey="Regis, Jean" sort="Regis, Jean" uniqKey="Regis J" first="Jean" last="Regis">Jean Regis</name></author><author><name sortKey="Cherif, Andre Ali" sort="Cherif, Andre Ali" uniqKey="Cherif A" first="André Ali" last="Cherif">André Ali Cherif</name></author><author><name sortKey="Peragut, Jean Claude" sort="Peragut, Jean Claude" uniqKey="Peragut J" first="Jean Claude" last="Peragut">Jean Claude Peragut</name></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean Philippe" last="Azulay">Jean Philippe Azulay</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20501</idno><idno type="RBID">pubmed:15858803</idno><idno type="pmid">15858803</idno><idno type="wicri:Area/PubMed/Corpus">003058</idno><idno 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Christelle" uniqKey="Baunez C" first="Christelle" last="Baunez">Christelle Baunez</name></author><author><name sortKey="Henry, Jean Marc" sort="Henry, Jean Marc" uniqKey="Henry J" first="Jean Marc" last="Henry">Jean Marc Henry</name></author><author><name sortKey="Delfini, Marie" sort="Delfini, Marie" uniqKey="Delfini M" first="Marie" last="Delfini">Marie Delfini</name></author><author><name sortKey="Regis, Jean" sort="Regis, Jean" uniqKey="Regis J" first="Jean" last="Regis">Jean Regis</name></author><author><name sortKey="Cherif, Andre Ali" sort="Cherif, Andre Ali" uniqKey="Cherif A" first="André Ali" last="Cherif">André Ali Cherif</name></author><author><name sortKey="Peragut, Jean Claude" sort="Peragut, Jean Claude" uniqKey="Peragut J" first="Jean Claude" last="Peragut">Jean Claude Peragut</name></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean Philippe" last="Azulay">Jean Philippe Azulay</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Behavior, Addictive (complications)</term><term>Behavior, Addictive (therapy)</term><term>Clinical Protocols</term><term>Deep Brain Stimulation (methods)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus (radiation effects)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Behavior, Addictive</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Behavior, Addictive</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Clinical Protocols</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high-frequency STN stimulation, and this treatment may even cure the addiction.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Marseille</li></settlement></list><tree><noCountry><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean Philippe" last="Azulay">Jean Philippe Azulay</name><name sortKey="Baunez, Christelle" sort="Baunez, Christelle" uniqKey="Baunez C" first="Christelle" last="Baunez">Christelle Baunez</name><name sortKey="Cherif, Andre Ali" sort="Cherif, Andre Ali" uniqKey="Cherif A" first="André Ali" last="Cherif">André Ali Cherif</name><name sortKey="Delfini, Marie" sort="Delfini, Marie" uniqKey="Delfini M" first="Marie" last="Delfini">Marie Delfini</name><name sortKey="Henry, Jean Marc" sort="Henry, Jean Marc" uniqKey="Henry J" first="Jean Marc" last="Henry">Jean Marc Henry</name><name sortKey="Peragut, Jean Claude" sort="Peragut, Jean Claude" uniqKey="Peragut J" first="Jean Claude" last="Peragut">Jean Claude Peragut</name><name sortKey="Regis, Jean" sort="Regis, Jean" uniqKey="Regis J" first="Jean" last="Regis">Jean Regis</name></noCountry><country name="France"><noRegion><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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