Rebound psychosis: effect of discontinuation of antipsychotics in Parkinson's disease.
Identifieur interne : 001022 ( Ncbi/Checkpoint ); précédent : 001021; suivant : 001023Rebound psychosis: effect of discontinuation of antipsychotics in Parkinson's disease.
Auteurs : Hubert H. Fernandez [États-Unis] ; Martha E. Trieschmann ; Michael S. OkunSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antipsychotic Agents (adverse effects), Brief Psychiatric Rating Scale, Clozapine (adverse effects), Dibenzothiazepines (adverse effects), Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Tolerance, Female, Humans, Male, Parkinson Disease (complications), Prospective Studies, Psychotic Disorders (complications), Psychotic Disorders (drug therapy), Recurrence, Time Factors.
- MESH :
- chemical , adverse effects : Antipsychotic Agents, Clozapine, Dibenzothiazepines.
- complications : Parkinson Disease, Psychotic Disorders.
- drug therapy : Psychotic Disorders.
- Aged, Aged, 80 and over, Brief Psychiatric Rating Scale, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Tolerance, Female, Humans, Male, Prospective Studies, Recurrence, Time Factors.
Abstract
To determine whether psychiatrically stable patients with a history of drug-induced psychosis could be successfully weaned off their antipsychotic drug, we offered consecutive Parkinson disease (PD) patients on quetiapine or clozapine, who were free of any on-going psychosis, to be slowly weaned off their antipsychotic drug. Before the study was aborted 6 PD patients (mean age, 78 years) with an average antipsychotic exposure of 20 months (5 on quetiapine, 1 on clozapine) were enrolled. After the antipsychotic agent was discontinued, psychosis recurred in 5 of 6 patients. In 3 patients the "rebound psychosis" was worse than the original psychotic episode and required subsequent higher antipsychotic medication doses.
DOI: 10.1002/mds.20260
PubMed: 15390047
Affiliations:
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pubmed:15390047Le document en format XML
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Fernandez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Florida/McKnight Brain Institute, Movement Disorders Program, Gainesville, Florida 32610, USA. fernandez@neurology.ufl.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Florida/McKnight Brain Institute, Movement Disorders Program, Gainesville, Florida 32610</wicri:regionArea><wicri:noRegion>Florida 32610</wicri:noRegion></affiliation></author><author><name sortKey="Trieschmann, Martha E" sort="Trieschmann, Martha E" uniqKey="Trieschmann M" first="Martha E" last="Trieschmann">Martha E. Trieschmann</name></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antipsychotic Agents (adverse effects)</term><term>Brief Psychiatric Rating Scale</term><term>Clozapine (adverse effects)</term><term>Dibenzothiazepines (adverse effects)</term><term>Dose-Response Relationship, Drug</term><term>Drug Administration Schedule</term><term>Drug Tolerance</term><term>Female</term><term>Humans</term><term>Male</term><term>Parkinson Disease (complications)</term><term>Prospective Studies</term><term>Psychotic Disorders (complications)</term><term>Psychotic Disorders (drug therapy)</term><term>Recurrence</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antipsychotic Agents</term><term>Clozapine</term><term>Dibenzothiazepines</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>Psychotic Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Psychotic Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brief Psychiatric Rating Scale</term><term>Dose-Response Relationship, Drug</term><term>Drug Administration Schedule</term><term>Drug Tolerance</term><term>Female</term><term>Humans</term><term>Male</term><term>Prospective Studies</term><term>Recurrence</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine whether psychiatrically stable patients with a history of drug-induced psychosis could be successfully weaned off their antipsychotic drug, we offered consecutive Parkinson disease (PD) patients on quetiapine or clozapine, who were free of any on-going psychosis, to be slowly weaned off their antipsychotic drug. Before the study was aborted 6 PD patients (mean age, 78 years) with an average antipsychotic exposure of 20 months (5 on quetiapine, 1 on clozapine) were enrolled. After the antipsychotic agent was discontinued, psychosis recurred in 5 of 6 patients. In 3 patients the "rebound psychosis" was worse than the original psychotic episode and required subsequent higher antipsychotic medication doses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name><name sortKey="Trieschmann, Martha E" sort="Trieschmann, Martha E" uniqKey="Trieschmann M" first="Martha E" last="Trieschmann">Martha E. Trieschmann</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. 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